Molecular population genetics of the Polycomb genes in Drosophila subobscura

Polycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolutio...

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Autores: Calvo Martín, Juan Manuel, Papaceit Vidal, Montserrat, Segarra Robert, Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/122640
Acceso en línea:https://hdl.handle.net/2445/122640
Access Level:acceso abierto
Palabra clave:Drosòfila subobscura
Mapatge cromosòmic humà
Genètica molecular
Drosophila subobscura
Human gene mapping
Molecular genetics
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spelling Molecular population genetics of the Polycomb genes in Drosophila subobscuraCalvo Martín, Juan ManuelPapaceit Vidal, MontserratSegarra Robert, CarmenDrosòfila subobscuraMapatge cromosòmic humàGenètica molecularDrosophila subobscuraHuman gene mappingMolecular geneticsPolycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolution among them and an acceleration of the nonsynonymous evolutionary rate in the lineage ancestral to the obscura group species, mainly in subunits of the Pcl-PRC2 complex. Herein, we have studied the nucleotide polymorphism of PcG genes in a natural population of D. subobscura to detect whether natural selection has also modulated the evolution of these important regulatory genes in a more recent time scale. Results show that most genes are under the action of purifying selection and present a level and pattern of polymorphism consistent with predictions of the neutral model, the exceptions being Su(z)12 and Pho. MK tests indicate an accumulation of adaptive changes in the SU(Z)12 protein during the divergence of D. subobscura and D. guanche. In contrast, the HKA test shows a deficit of polymorphism at Pho. The most likely explanation for this reduced variation is the location of this gene in the dot-like chromosome and would indicate that this chromosome also has null or very low recombination in D. subobscura, as reported in D. melanogaster.Public Library of Science (PLoS)2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/122640Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0185005PLoS One, 2017, vol. 12, num. 9https://doi.org/10.1371/journal.pone.0185005cc-by (c) Calvo Martín, Juan M. et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1226402026-05-27T06:46:51Z
dc.title.none.fl_str_mv Molecular population genetics of the Polycomb genes in Drosophila subobscura
title Molecular population genetics of the Polycomb genes in Drosophila subobscura
spellingShingle Molecular population genetics of the Polycomb genes in Drosophila subobscura
Calvo Martín, Juan Manuel
Drosòfila subobscura
Mapatge cromosòmic humà
Genètica molecular
Drosophila subobscura
Human gene mapping
Molecular genetics
title_short Molecular population genetics of the Polycomb genes in Drosophila subobscura
title_full Molecular population genetics of the Polycomb genes in Drosophila subobscura
title_fullStr Molecular population genetics of the Polycomb genes in Drosophila subobscura
title_full_unstemmed Molecular population genetics of the Polycomb genes in Drosophila subobscura
title_sort Molecular population genetics of the Polycomb genes in Drosophila subobscura
dc.creator.none.fl_str_mv Calvo Martín, Juan Manuel
Papaceit Vidal, Montserrat
Segarra Robert, Carmen
author Calvo Martín, Juan Manuel
author_facet Calvo Martín, Juan Manuel
Papaceit Vidal, Montserrat
Segarra Robert, Carmen
author_role author
author2 Papaceit Vidal, Montserrat
Segarra Robert, Carmen
author2_role author
author
dc.subject.none.fl_str_mv Drosòfila subobscura
Mapatge cromosòmic humà
Genètica molecular
Drosophila subobscura
Human gene mapping
Molecular genetics
topic Drosòfila subobscura
Mapatge cromosòmic humà
Genètica molecular
Drosophila subobscura
Human gene mapping
Molecular genetics
description Polycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolution among them and an acceleration of the nonsynonymous evolutionary rate in the lineage ancestral to the obscura group species, mainly in subunits of the Pcl-PRC2 complex. Herein, we have studied the nucleotide polymorphism of PcG genes in a natural population of D. subobscura to detect whether natural selection has also modulated the evolution of these important regulatory genes in a more recent time scale. Results show that most genes are under the action of purifying selection and present a level and pattern of polymorphism consistent with predictions of the neutral model, the exceptions being Su(z)12 and Pho. MK tests indicate an accumulation of adaptive changes in the SU(Z)12 protein during the divergence of D. subobscura and D. guanche. In contrast, the HKA test shows a deficit of polymorphism at Pho. The most likely explanation for this reduced variation is the location of this gene in the dot-like chromosome and would indicate that this chromosome also has null or very low recombination in D. subobscura, as reported in D. melanogaster.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122640
url https://hdl.handle.net/2445/122640
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0185005
PLoS One, 2017, vol. 12, num. 9
https://doi.org/10.1371/journal.pone.0185005
dc.rights.none.fl_str_mv cc-by (c) Calvo Martín, Juan M. et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Calvo Martín, Juan M. et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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