Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality

The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring...

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Detalles Bibliográficos
Autores: González Nieto, Daniel, Fernández García, Laura, Pérez Rigueiro, José, Guinea, Gustavo, Panetsos Petrova, Fivos
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/19111
Acceso en línea:https://hdl.handle.net/20.500.14352/19111
Access Level:acceso abierto
Palabra clave:Biomaterials
Hydrogels
Stem cells
Stroke
Brain repair
Neurociencias (Medicina)
Biotecnología
Bioquímica (Biología)
2490 Neurociencias
3399 Otras Especialidades Tecnológicas
2302 Bioquímica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/19111
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spelling Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or RealityGonzález Nieto, DanielFernández García, LauraPérez Rigueiro, JoséGuinea, GustavoPanetsos Petrova, FivosBiomaterialsHydrogelsStem cellsStrokeBrain repairNeurociencias (Medicina)BiotecnologíaBioquímica (Biología)2490 Neurociencias3399 Otras Especialidades Tecnológicas2302 BioquímicaThe use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as well as their capacity to produce and deliver neuroprotective and neuroregenerative factors in the host tissue. Along this article, we review past and current trends in experimental and translational research to understand the opportunities, benefits, and types of tentative hydrogel-based applications for the treatment of cerebral disorders. Although the use of hydrogels for brain disorders has been restricted to the experimental area, the current level of knowledge anticipates an intense development of this field to reach clinics in forthcoming years.MDPIUniversidad Complutense de Madrid20182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/19111reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/191112026-06-02T12:44:21Z
dc.title.none.fl_str_mv Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
title Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
spellingShingle Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
González Nieto, Daniel
Biomaterials
Hydrogels
Stem cells
Stroke
Brain repair
Neurociencias (Medicina)
Biotecnología
Bioquímica (Biología)
2490 Neurociencias
3399 Otras Especialidades Tecnológicas
2302 Bioquímica
title_short Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
title_full Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
title_fullStr Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
title_full_unstemmed Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
title_sort Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality
dc.creator.none.fl_str_mv González Nieto, Daniel
Fernández García, Laura
Pérez Rigueiro, José
Guinea, Gustavo
Panetsos Petrova, Fivos
author González Nieto, Daniel
author_facet González Nieto, Daniel
Fernández García, Laura
Pérez Rigueiro, José
Guinea, Gustavo
Panetsos Petrova, Fivos
author_role author
author2 Fernández García, Laura
Pérez Rigueiro, José
Guinea, Gustavo
Panetsos Petrova, Fivos
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Biomaterials
Hydrogels
Stem cells
Stroke
Brain repair
Neurociencias (Medicina)
Biotecnología
Bioquímica (Biología)
2490 Neurociencias
3399 Otras Especialidades Tecnológicas
2302 Bioquímica
topic Biomaterials
Hydrogels
Stem cells
Stroke
Brain repair
Neurociencias (Medicina)
Biotecnología
Bioquímica (Biología)
2490 Neurociencias
3399 Otras Especialidades Tecnológicas
2302 Bioquímica
description The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as well as their capacity to produce and deliver neuroprotective and neuroregenerative factors in the host tissue. Along this article, we review past and current trends in experimental and translational research to understand the opportunities, benefits, and types of tentative hydrogel-based applications for the treatment of cerebral disorders. Although the use of hydrogels for brain disorders has been restricted to the experimental area, the current level of knowledge anticipates an intense development of this field to reach clinics in forthcoming years.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/19111
url https://hdl.handle.net/20.500.14352/19111
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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