A DSC study of the non-isothermal cold crystallization and relaxation effects in ubiquinone and ubiquinol

Cold crystallization effects, the kinetics-dependent crystallization behaviour of amorphous ubiquinone and ubiquinol produced in a series of quenching from-the-melt experiments, have been extensively studied through the combination of differential scanning calorimetry (DSC) and powder X-ray diffract...

Descripción completa

Detalles Bibliográficos
Autores: Barbas Cañero, Rafael, Sande, Dafne de, Bofill, Lídia, Prohens López, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226787
Acceso en línea:https://hdl.handle.net/2445/226787
Access Level:acceso abierto
Palabra clave:Polimorfisme (Cristal·lografia)
Dispositius d'administració de medicaments
Polymorphism (Crystallography)
Drug delivery devices
Descripción
Sumario:Cold crystallization effects, the kinetics-dependent crystallization behaviour of amorphous ubiquinone and ubiquinol produced in a series of quenching from-the-melt experiments, have been extensively studied through the combination of differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) techniques under a big diversity of experimental conditions, which has allowed the exploration of their poorly understood polymorphic landscapes. The investigation revealed the existence of a non-previously described polymorph together with a rich set of kinetically dependent transformations, which were observed for the first time by thermal analysis conducted at different heating rates in both oxidized and reduced solid forms of Coenzyme Q10.