Monitorización de digoxina en pacientes ancianos
Digoxin is a frequently prescribed drug in the elderly population. Estimated glomerular filtration rate is used to adjust dosages. The HUGE value is a tool for differentiating the presence or absence of chronic kidney disease in elderly patients. The objective was to investigate the usefulness of an...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2017 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositório: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/133706 |
| Acesso em linha: | http://hdl.handle.net/10366/133706 |
| Access Level: | Acceso aberto |
| Palavra-chave: | digoxina monitorización anciano valor HUGE PKS (Abbottbase pharmacokinetic system) digoxin monitoring elder HUGE value |
| Resumo: | Digoxin is a frequently prescribed drug in the elderly population. Estimated glomerular filtration rate is used to adjust dosages. The HUGE value is a tool for differentiating the presence or absence of chronic kidney disease in elderly patients. The objective was to investigate the usefulness of an equation based on the HUGE value: C= 0,281+0,029 x HUGE + 5, 38 x Dose to predict the initial dose of digoxin in patients older than 70 years. This equation was validated retrospectively (33 patients) and prospectively (35 patients) in comparison with the PKS® method (Pharmacokinetic System, Abbott) based on creatinine clearance. The predictive performance of our equation was better than that obtained with the compared method. In conclusion, clinical validity and superiority of an equation based on the HUGE value is presented. Our results support the need to perform digoxin dosing in elderly people bearing in mind the changes in renal physiology secondary to ageing and not merely the estimated glomerular filtration rate. |
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