Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts

The simultaneous fractionation and precipitation of an ethanolic extract of rosemary (Rosmarinus officinalis L.) using supercritical carbon dioxide anti-solvent technique was studied, with the target of separate in two different fractions the key antioxidants of rosemary (i.e. rosmarinic acid, carno...

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Detalhes bibliográficos
Autores: Quintana, Somaris E., Villanueva-Bermejo, David, Reglero, Guillermo, García-Risco, Mónica R., Fornari, Tiziana
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/205015
Acesso em linha:http://hdl.handle.net/10261/205015
Access Level:Acceso aberto
Palavra-chave:Supercritical antisolvent precipitation
Rosemary
Antioxidant activity
Morphology
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spelling Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extractsQuintana, Somaris E.Villanueva-Bermejo, DavidReglero, GuillermoGarcía-Risco, Mónica R.Fornari, TizianaSupercritical antisolvent precipitationRosemaryAntioxidant activityMorphologyThe simultaneous fractionation and precipitation of an ethanolic extract of rosemary (Rosmarinus officinalis L.) using supercritical carbon dioxide anti-solvent technique was studied, with the target of separate in two different fractions the key antioxidants of rosemary (i.e. rosmarinic acid, carnosic acid and carnosol). The effect of pressure and temperature on the fractionation process was investigated, together with the morphology and particle size distribution of the precipitates. Additionally, the chemical composition of the oleoresins were analyzed and reported. In the range of pressures (9–20 MPa) and temperatures (313–333 K) used in this work, the precipitates presented a 2–3 fold enrichment of rosmarinic acid, while carnosic acid and carnosol were concentrated (2–3 fold enrichment) in the oleoresin fractions. Furthermore, in general, oleoresins presented higher antioxidant activity than precipitates. Particles produced with a nozzle of diameter 101.6 μm were smaller and more spherical with increasing pressure (mean value 4–10 μm at 20 MPa) and decreasing temperature.The authors gratefully acknowledge the financial support from Ministerio de Economía y Competitividad of Spain (Proyect AGL2016-76736-C3-1-R). Somaris E. Quintana is grateful for the funding provided by Gobernación de Bolivar and Fundación Ceiba, Colombia, in the project “Bolívar Gana con Ciencia”.Peer reviewedElsevierGobernación de BolivarMinisterio de Economía y Competitividad (España)Fundación CeiBAConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/205015reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76736-C3-1-Rhttps://doi.org/10.1016/j.jcou.2019.07.032Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2050152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
title Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
spellingShingle Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
Quintana, Somaris E.
Supercritical antisolvent precipitation
Rosemary
Antioxidant activity
Morphology
title_short Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
title_full Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
title_fullStr Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
title_full_unstemmed Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
title_sort Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts
dc.creator.none.fl_str_mv Quintana, Somaris E.
Villanueva-Bermejo, David
Reglero, Guillermo
García-Risco, Mónica R.
Fornari, Tiziana
author Quintana, Somaris E.
author_facet Quintana, Somaris E.
Villanueva-Bermejo, David
Reglero, Guillermo
García-Risco, Mónica R.
Fornari, Tiziana
author_role author
author2 Villanueva-Bermejo, David
Reglero, Guillermo
García-Risco, Mónica R.
Fornari, Tiziana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Gobernación de Bolivar
Ministerio de Economía y Competitividad (España)
Fundación CeiBA
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Supercritical antisolvent precipitation
Rosemary
Antioxidant activity
Morphology
topic Supercritical antisolvent precipitation
Rosemary
Antioxidant activity
Morphology
description The simultaneous fractionation and precipitation of an ethanolic extract of rosemary (Rosmarinus officinalis L.) using supercritical carbon dioxide anti-solvent technique was studied, with the target of separate in two different fractions the key antioxidants of rosemary (i.e. rosmarinic acid, carnosic acid and carnosol). The effect of pressure and temperature on the fractionation process was investigated, together with the morphology and particle size distribution of the precipitates. Additionally, the chemical composition of the oleoresins were analyzed and reported. In the range of pressures (9–20 MPa) and temperatures (313–333 K) used in this work, the precipitates presented a 2–3 fold enrichment of rosmarinic acid, while carnosic acid and carnosol were concentrated (2–3 fold enrichment) in the oleoresin fractions. Furthermore, in general, oleoresins presented higher antioxidant activity than precipitates. Particles produced with a nozzle of diameter 101.6 μm were smaller and more spherical with increasing pressure (mean value 4–10 μm at 20 MPa) and decreasing temperature.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/205015
url http://hdl.handle.net/10261/205015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76736-C3-1-R
https://doi.org/10.1016/j.jcou.2019.07.032
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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