Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications

Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a populat...

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Autores: Rodríguez Matarredona, Esperanza, Pastor Loro, Ángel Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/89315
Acceso en línea:https://hdl.handle.net/11441/89315
https://doi.org/10.3389/fonc.2019.00779
Access Level:acceso abierto
Palabra clave:glioblastoma stem cells
tumor microenvironment
adult neurogenesis
neural stem cells
subventricular zone
driver mutations
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spelling Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic ImplicationsRodríguez Matarredona, EsperanzaPastor Loro, Ángel Manuelglioblastoma stem cellstumor microenvironmentadult neurogenesisneural stem cellssubventricular zonedriver mutationsHuman glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a population of glioma stem cells (GSCs), with self-renewal ability, which are partly responsible for the tumor resistance to therapy and for the tumor recurrence after treatment. The human adult subventricular zone contains astrocyte-like neural stem cells (NSCs) that are probably reminiscent of the radial glia present in embryonic brain development. There are numerous molecules involved in the biology of subventricular zone NSCs that are also instrumental in glioblastoma development. These include cytoskeletal proteins, telomerase, tumor suppressor proteins, transcription factors, and growth factors. Interestingly, genes encoding these molecules are frequently mutated in glioblastoma cells. Indeed, it has been recently shown that NSCs in the subventricular zone are a potential cell of origin that contains the driver mutations of human glioblastoma. In this review we will describe common features between GSCs and subventricular zone NSCs, and we will discuss the relevance of this important finding in terms of possible future therapeutic strategies.España Ministerio de Ciencia, Innovación y Universidades PGC2018-094654-B-100España Junta de Andalucía Grant: BIO-297Frontiers MediaFisiología2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/89315https://doi.org/10.3389/fonc.2019.00779reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Oncology, 9 (art. 779), 1-12.PGC2018-094654-B-100Grant: BIO-297http://dx.doi.org/10.3389/fonc.2019.00779info:eu-repo/semantics/openAccessoai:idus.us.es:11441/893152026-06-17T12:51:07Z
dc.title.none.fl_str_mv Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
title Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
spellingShingle Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
Rodríguez Matarredona, Esperanza
glioblastoma stem cells
tumor microenvironment
adult neurogenesis
neural stem cells
subventricular zone
driver mutations
title_short Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
title_full Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
title_fullStr Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
title_full_unstemmed Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
title_sort Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
dc.creator.none.fl_str_mv Rodríguez Matarredona, Esperanza
Pastor Loro, Ángel Manuel
author Rodríguez Matarredona, Esperanza
author_facet Rodríguez Matarredona, Esperanza
Pastor Loro, Ángel Manuel
author_role author
author2 Pastor Loro, Ángel Manuel
author2_role author
dc.contributor.none.fl_str_mv Fisiología
dc.subject.none.fl_str_mv glioblastoma stem cells
tumor microenvironment
adult neurogenesis
neural stem cells
subventricular zone
driver mutations
topic glioblastoma stem cells
tumor microenvironment
adult neurogenesis
neural stem cells
subventricular zone
driver mutations
description Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a population of glioma stem cells (GSCs), with self-renewal ability, which are partly responsible for the tumor resistance to therapy and for the tumor recurrence after treatment. The human adult subventricular zone contains astrocyte-like neural stem cells (NSCs) that are probably reminiscent of the radial glia present in embryonic brain development. There are numerous molecules involved in the biology of subventricular zone NSCs that are also instrumental in glioblastoma development. These include cytoskeletal proteins, telomerase, tumor suppressor proteins, transcription factors, and growth factors. Interestingly, genes encoding these molecules are frequently mutated in glioblastoma cells. Indeed, it has been recently shown that NSCs in the subventricular zone are a potential cell of origin that contains the driver mutations of human glioblastoma. In this review we will describe common features between GSCs and subventricular zone NSCs, and we will discuss the relevance of this important finding in terms of possible future therapeutic strategies.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/89315
https://doi.org/10.3389/fonc.2019.00779
url https://hdl.handle.net/11441/89315
https://doi.org/10.3389/fonc.2019.00779
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Oncology, 9 (art. 779), 1-12.
PGC2018-094654-B-100
Grant: BIO-297
http://dx.doi.org/10.3389/fonc.2019.00779
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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