Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concen...

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Autores: Mesquida, Marina, Molins Monteys, Blanca, Llorenç, Victor, Sainz de la Maza Serra, María Teresa, Hernandez, Maria Victoria, Espinosa Garriga, Gerard, Adán Civera, Alfredo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/119678
Acceso en línea:https://hdl.handle.net/2445/119678
Access Level:acceso abierto
Palabra clave:Citoquines
Proteïnes de la sang
Uveïtis
Malaltia de Behçet
Inflamació
Cytokines
Blood proteins
Uveitis
Behçet's disease
Inflammation
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spelling Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's diseaseMesquida, MarinaMolins Monteys, BlancaLlorenç, VictorSainz de la Maza Serra, María TeresaHernandez, Maria VictoriaEspinosa Garriga, GerardAdán Civera, AlfredoCitoquinesProteïnes de la sangUveïtisMalaltia de BehçetInflamacióCytokinesBlood proteinsUveitisBehçet's diseaseInflammationThe aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.Hindawi Publishing Corporation2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/119678Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1155/2014/396204Mediators of Inflammation, 2014, vol. 2014https://doi.org/10.1155/2014/396204cc-by (c) Mesquida, Marina et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1196782026-05-27T06:46:51Z
dc.title.none.fl_str_mv Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
title Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
spellingShingle Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
Mesquida, Marina
Citoquines
Proteïnes de la sang
Uveïtis
Malaltia de Behçet
Inflamació
Cytokines
Blood proteins
Uveitis
Behçet's disease
Inflammation
title_short Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
title_full Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
title_fullStr Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
title_full_unstemmed Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
title_sort Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
dc.creator.none.fl_str_mv Mesquida, Marina
Molins Monteys, Blanca
Llorenç, Victor
Sainz de la Maza Serra, María Teresa
Hernandez, Maria Victoria
Espinosa Garriga, Gerard
Adán Civera, Alfredo
author Mesquida, Marina
author_facet Mesquida, Marina
Molins Monteys, Blanca
Llorenç, Victor
Sainz de la Maza Serra, María Teresa
Hernandez, Maria Victoria
Espinosa Garriga, Gerard
Adán Civera, Alfredo
author_role author
author2 Molins Monteys, Blanca
Llorenç, Victor
Sainz de la Maza Serra, María Teresa
Hernandez, Maria Victoria
Espinosa Garriga, Gerard
Adán Civera, Alfredo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Citoquines
Proteïnes de la sang
Uveïtis
Malaltia de Behçet
Inflamació
Cytokines
Blood proteins
Uveitis
Behçet's disease
Inflammation
topic Citoquines
Proteïnes de la sang
Uveïtis
Malaltia de Behçet
Inflamació
Cytokines
Blood proteins
Uveitis
Behçet's disease
Inflammation
description The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119678
url https://hdl.handle.net/2445/119678
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1155/2014/396204
Mediators of Inflammation, 2014, vol. 2014
https://doi.org/10.1155/2014/396204
dc.rights.none.fl_str_mv cc-by (c) Mesquida, Marina et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mesquida, Marina et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419762695536640
score 15.300719

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