Theobromine is responsible for the effects of cocoa on the antibody immune status of rats
Background: A 10% cocoa-enriched diet influences immune system functionality including the prevention of the antibody response and the induction of lower immunoglobulin (Ig) concentrations. However, neither cocoa polyphenols nor cocoa fiber can totally explain these immunoregulatory properties. Obje...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/165542 |
| Acceso en línea: | https://hdl.handle.net/2445/165542 |
| Access Level: | acceso abierto |
| Palabra clave: | Cacau Sistema immunitari Dieta Farmacologia Metabolisme Immunoglobulines Rates (Animals de laboratori) Cocoa Immune system Diet Pharmacology Metabolism Immunoglobulins Rats as laboratory animals |
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Theobromine is responsible for the effects of cocoa on the antibody immune status of ratsCamps i Bossacoma, MarionaPérez-Cano, Francisco J.Franch i Masferrer, ÀngelsCastell, MargaridaCacauSistema immunitariDietaFarmacologiaMetabolismeImmunoglobulinesRates (Animals de laboratori)CocoaImmune systemDietPharmacologyMetabolismImmunoglobulinsRats as laboratory animalsBackground: A 10% cocoa-enriched diet influences immune system functionality including the prevention of the antibody response and the induction of lower immunoglobulin (Ig) concentrations. However, neither cocoa polyphenols nor cocoa fiber can totally explain these immunoregulatory properties. Objectives: This study aimed to establish the influence of cocoa theobromine in systemic and intestinal Ig concentrations and to determine the effect of cocoa or theobromine feeding on lymphoid tissue lymphocyte composition. Methods: Three-week-old female Lewis rats were fed either a standard diet (AIN-93M; RF group), a 10%cocoa diet (CC group), or a 0.25% theobromine diet (the same amount provided by the cocoa diet; TB group) in 2 separate experiments that lasted 19 (experiment 1) or 8 (experiment 2) d. Serum IgG, IgM, IgA, and intestinal secretory IgA (sIgA) concentrations were determined. In addition, at the end of experiment 2, thymus, mesenteric lymph node (MLN), and spleen lymphocyte populations were analyzed. Results: Both CC and TB groups in experiments 1 and 2 showed similar serum IgG, IgM, and IgA and intestinal sIgA concentrations, which were lower than those in the RF group (46-98% lower in experiment 1 and 23-91% lower in experiment 2; P < 0.05). In addition, in experiment 2, the cocoa and theobromine diets similarly changed the thymocyte composition by increasing CD4−CD8− (+133%) and CD4+CD8− (+53%) proportions (P < 0.01), changed the MLN composition by decreasing the percentage of T-helper (Th) lymphocytes (-3%) (P = 0.015), and changed the spleen composition by increasing the proportion of Th lymphocytes (+9%) (P < 0.001) after 1 wk of diet treatment. Conclusions: The theobromine in cocoa plays an immunoregulatory role that is responsible for cocoa's influence on both systemic and intestinal antibody concentrations and also for modifying lymphoid tissue lymphocyte composition in young healthy Lewis rats. The majority of these changes are observed after a single week of being fed a diet containing 0.25% theobromine.American Society for Nutrition2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion8 p.application/pdfhttps://hdl.handle.net/2445/165542Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1093/jn/nxx056Journal of Nutrition, 2018, vol. 148, num. 3, p. 464-471https://doi.org/10.1093/jn/nxx056(c) American Society for Nutrition, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1655422026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| title |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| spellingShingle |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats Camps i Bossacoma, Mariona Cacau Sistema immunitari Dieta Farmacologia Metabolisme Immunoglobulines Rates (Animals de laboratori) Cocoa Immune system Diet Pharmacology Metabolism Immunoglobulins Rats as laboratory animals |
| title_short |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| title_full |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| title_fullStr |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| title_full_unstemmed |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| title_sort |
Theobromine is responsible for the effects of cocoa on the antibody immune status of rats |
| dc.creator.none.fl_str_mv |
Camps i Bossacoma, Mariona Pérez-Cano, Francisco J. Franch i Masferrer, Àngels Castell, Margarida |
| author |
Camps i Bossacoma, Mariona |
| author_facet |
Camps i Bossacoma, Mariona Pérez-Cano, Francisco J. Franch i Masferrer, Àngels Castell, Margarida |
| author_role |
author |
| author2 |
Pérez-Cano, Francisco J. Franch i Masferrer, Àngels Castell, Margarida |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Cacau Sistema immunitari Dieta Farmacologia Metabolisme Immunoglobulines Rates (Animals de laboratori) Cocoa Immune system Diet Pharmacology Metabolism Immunoglobulins Rats as laboratory animals |
| topic |
Cacau Sistema immunitari Dieta Farmacologia Metabolisme Immunoglobulines Rates (Animals de laboratori) Cocoa Immune system Diet Pharmacology Metabolism Immunoglobulins Rats as laboratory animals |
| description |
Background: A 10% cocoa-enriched diet influences immune system functionality including the prevention of the antibody response and the induction of lower immunoglobulin (Ig) concentrations. However, neither cocoa polyphenols nor cocoa fiber can totally explain these immunoregulatory properties. Objectives: This study aimed to establish the influence of cocoa theobromine in systemic and intestinal Ig concentrations and to determine the effect of cocoa or theobromine feeding on lymphoid tissue lymphocyte composition. Methods: Three-week-old female Lewis rats were fed either a standard diet (AIN-93M; RF group), a 10%cocoa diet (CC group), or a 0.25% theobromine diet (the same amount provided by the cocoa diet; TB group) in 2 separate experiments that lasted 19 (experiment 1) or 8 (experiment 2) d. Serum IgG, IgM, IgA, and intestinal secretory IgA (sIgA) concentrations were determined. In addition, at the end of experiment 2, thymus, mesenteric lymph node (MLN), and spleen lymphocyte populations were analyzed. Results: Both CC and TB groups in experiments 1 and 2 showed similar serum IgG, IgM, and IgA and intestinal sIgA concentrations, which were lower than those in the RF group (46-98% lower in experiment 1 and 23-91% lower in experiment 2; P < 0.05). In addition, in experiment 2, the cocoa and theobromine diets similarly changed the thymocyte composition by increasing CD4−CD8− (+133%) and CD4+CD8− (+53%) proportions (P < 0.01), changed the MLN composition by decreasing the percentage of T-helper (Th) lymphocytes (-3%) (P = 0.015), and changed the spleen composition by increasing the proportion of Th lymphocytes (+9%) (P < 0.001) after 1 wk of diet treatment. Conclusions: The theobromine in cocoa plays an immunoregulatory role that is responsible for cocoa's influence on both systemic and intestinal antibody concentrations and also for modifying lymphoid tissue lymphocyte composition in young healthy Lewis rats. The majority of these changes are observed after a single week of being fed a diet containing 0.25% theobromine. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/165542 |
| url |
https://hdl.handle.net/2445/165542 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1093/jn/nxx056 Journal of Nutrition, 2018, vol. 148, num. 3, p. 464-471 https://doi.org/10.1093/jn/nxx056 |
| dc.rights.none.fl_str_mv |
(c) American Society for Nutrition, 2018 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) American Society for Nutrition, 2018 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
8 p. application/pdf |
| dc.publisher.none.fl_str_mv |
American Society for Nutrition |
| publisher.none.fl_str_mv |
American Society for Nutrition |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Bioquímica i Fisiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15,811543 |