Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.

Pérez-Belmonte, Luis M; Moreno-Santos, Inmaculada; Cabrera-Bueno, Fernando; Sánchez-Espín, Gemma; Castellano, Daniel; Such, Miguel; Crespo-Leiro, María G; Carrasco-Chinchilla, Fernando; Alonso-Pulpón, Luis; López-Garrido, Miguel; Ruiz-Salas, Amalio; Becerra-Muñoz, Víctor M; Gómez-Doblas, Juan J; de Teresa-Galván, Eduardo; Jiménez-Navarro, Manuel

Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.

Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be...

Descripción completa

Detalles Bibliográficos
Autores:	Pérez-Belmonte, Luis M, Moreno-Santos, Inmaculada, Cabrera-Bueno, Fernando, Sánchez-Espín, Gemma, Castellano, Daniel, Such, Miguel, Crespo-Leiro, María G, Carrasco-Chinchilla, Fernando, Alonso-Pulpón, Luis, López-Garrido, Miguel, Ruiz-Salas, Amalio, Becerra-Muñoz, Víctor M, Gómez-Doblas, Juan J, de Teresa-Galván, Eduardo, Jiménez-Navarro, Manuel
Tipo de recurso:	artículo
Fecha de publicación:	2017
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/17292
Acceso en línea:	http://hdl.handle.net/20.500.12105/17292
Access Level:	acceso abierto
Palabra clave:	Sterol regulatory element-binding proteins (SREBP) coronary artery disease epicardial adipose tissue type-2 diabetes mellitus. Adipose Tissue Aged Coronary Artery Disease Diabetes Mellitus, Type 2 Female Humans Lipid Metabolism Male Middle Aged Pericardium Risk Factors Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Sterols

id	ES_ccd778e22e99ddd0617b6b0534fbd042
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/17292
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.Pérez-Belmonte, Luis MMoreno-Santos, InmaculadaCabrera-Bueno, FernandoSánchez-Espín, GemmaCastellano, DanielSuch, MiguelCrespo-Leiro, María GCarrasco-Chinchilla, FernandoAlonso-Pulpón, LuisLópez-Garrido, MiguelRuiz-Salas, AmalioBecerra-Muñoz, Víctor MGómez-Doblas, Juan Jde Teresa-Galván, EduardoJiménez-Navarro, ManuelSterol regulatory element-binding proteins (SREBP)coronary artery diseaseepicardial adipose tissuetype-2 diabetes mellitus.Adipose TissueAgedCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansLipid MetabolismMaleMiddle AgedPericardiumRisk FactorsSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2SterolsObjectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p20242024-01-2320172017-02-2320172017-02-23research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17292reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/172922026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
title	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
spellingShingle	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Pérez-Belmonte, Luis M Sterol regulatory element-binding proteins (SREBP) coronary artery disease epicardial adipose tissue type-2 diabetes mellitus. Adipose Tissue Aged Coronary Artery Disease Diabetes Mellitus, Type 2 Female Humans Lipid Metabolism Male Middle Aged Pericardium Risk Factors Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Sterols
title_short	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
title_full	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
title_fullStr	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
title_full_unstemmed	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
title_sort	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
dc.creator.none.fl_str_mv	Pérez-Belmonte, Luis M Moreno-Santos, Inmaculada Cabrera-Bueno, Fernando Sánchez-Espín, Gemma Castellano, Daniel Such, Miguel Crespo-Leiro, María G Carrasco-Chinchilla, Fernando Alonso-Pulpón, Luis López-Garrido, Miguel Ruiz-Salas, Amalio Becerra-Muñoz, Víctor M Gómez-Doblas, Juan J de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel
author	Pérez-Belmonte, Luis M
author_facet	Pérez-Belmonte, Luis M Moreno-Santos, Inmaculada Cabrera-Bueno, Fernando Sánchez-Espín, Gemma Castellano, Daniel Such, Miguel Crespo-Leiro, María G Carrasco-Chinchilla, Fernando Alonso-Pulpón, Luis López-Garrido, Miguel Ruiz-Salas, Amalio Becerra-Muñoz, Víctor M Gómez-Doblas, Juan J de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel
author_role	author
author2	Moreno-Santos, Inmaculada Cabrera-Bueno, Fernando Sánchez-Espín, Gemma Castellano, Daniel Such, Miguel Crespo-Leiro, María G Carrasco-Chinchilla, Fernando Alonso-Pulpón, Luis López-Garrido, Miguel Ruiz-Salas, Amalio Becerra-Muñoz, Víctor M Gómez-Doblas, Juan J de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Sterol regulatory element-binding proteins (SREBP) coronary artery disease epicardial adipose tissue type-2 diabetes mellitus. Adipose Tissue Aged Coronary Artery Disease Diabetes Mellitus, Type 2 Female Humans Lipid Metabolism Male Middle Aged Pericardium Risk Factors Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Sterols
topic	Sterol regulatory element-binding proteins (SREBP) coronary artery disease epicardial adipose tissue type-2 diabetes mellitus. Adipose Tissue Aged Coronary Artery Disease Diabetes Mellitus, Type 2 Female Humans Lipid Metabolism Male Middle Aged Pericardium Risk Factors Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Sterols
description	Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
publishDate	2017
dc.date.none.fl_str_mv	2017 2017-02-23 2017 2017-02-23 2024 2024-01-23
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/17292
url	http://hdl.handle.net/20.500.12105/17292
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869419756437635072
score	15,812429

Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.

Similares en LA Referencia