Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study

Introduction: The GAH (Geriatric Assessment in Hematology) scale is a psychometrically valid tool aimed at identifying older patients with hematological malignancies at higher risk of treatment-related toxicity. Our objective in this study was to determine the weights for each dimension of the GAH s...

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Autores: de la Rubia Comos, Javier, González, Bernardo, Cruz-Jentoft, Alfonso J., Iglesias, Lorena, Jarque, Isidro, Pérez Persona, Ernesto, Lluch, Rafael, Marrero, Carmen, Zudaire, Maite, Gironella, Mercedes, Hernández-Rivas, José Ángel, Arnan, Montserrat, Olivier, Carmen, Encinas, Cristina, Soler, Juan Alfonso, Ramírez Payer, Ángel, Casado, Alfonso, Fernández, Patricia, Vilanova, David, Bonanad, Santiago
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/5110
Acceso en línea:http://hdl.handle.net/20.500.12466/5110
Access Level:acceso abierto
Palabra clave:Geriatric assessment
GAH scale
Hematological malignancies
Toxicity Chemotherapy
3201.01 Oncología
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spelling Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH studyde la Rubia Comos, JavierGonzález, BernardoCruz-Jentoft, Alfonso J.Iglesias, LorenaJarque, IsidroPérez Persona, ErnestoLluch, RafaelMarrero, CarmenZudaire, MaiteGironella, MercedesHernández-Rivas, José ÁngelArnan, MontserratOlivier, CarmenEncinas, CristinaSoler, Juan AlfonsoRamírez Payer, ÁngelCasado, AlfonsoFernández, PatriciaVilanova, DavidBonanad, SantiagoGeriatric assessmentGAH scaleHematological malignanciesToxicity Chemotherapy3201.01 OncologíaIntroduction: The GAH (Geriatric Assessment in Hematology) scale is a psychometrically valid tool aimed at identifying older patients with hematological malignancies at higher risk of treatment-related toxicity. Our objective in this study was to determine the weights for each dimension of the GAH scale and the cut-off point to reliably predict treatment tolerability in this population, estimated by a weighted receiver operating charac teristic (ROC) analysis and quantified by the area under the curve (AUC). Material and Methods: The RETROGAH was a retrospective cohort study including 126 patients who had pre viously participated in the GAH study. Patients were ≥ 65 years old with newly diagnosed myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), multiple myeloma (MM), or chronic lymphoid leukemia (CLL) and treated with standard front-line therapy within three months after having completed the GAH scale. Results: The optimal cut-off value of the GAH total score to discriminate patients at higher risk of treatment toxicity was 42, with 68.5% sensitivity and 55.8% specificity. Using this value, 66.1% of patients evaluated were found to develop some type of toxicity. The AUC was 0.6259 (95% CI: 0.512–0.739; p = 0.035). Discussion: The GAH scale not only would enable clinicians to individualize therapy based on individual risk of toxicity but also discriminate patients that will benefit most from intensive treatments from those requiring an adapted approach. While futures studies in clinical practice may improve the model and overcome its limitations, the GAH scale should not be used alone when making treatment decisions.20252025-01-1320232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/5110reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/51102026-06-19T08:32:07Z
dc.title.none.fl_str_mv Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
title Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
spellingShingle Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
de la Rubia Comos, Javier
Geriatric assessment
GAH scale
Hematological malignancies
Toxicity Chemotherapy
3201.01 Oncología
title_short Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
title_full Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
title_fullStr Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
title_full_unstemmed Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
title_sort Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study
dc.creator.none.fl_str_mv de la Rubia Comos, Javier
González, Bernardo
Cruz-Jentoft, Alfonso J.
Iglesias, Lorena
Jarque, Isidro
Pérez Persona, Ernesto
Lluch, Rafael
Marrero, Carmen
Zudaire, Maite
Gironella, Mercedes
Hernández-Rivas, José Ángel
Arnan, Montserrat
Olivier, Carmen
Encinas, Cristina
Soler, Juan Alfonso
Ramírez Payer, Ángel
Casado, Alfonso
Fernández, Patricia
Vilanova, David
Bonanad, Santiago
author de la Rubia Comos, Javier
author_facet de la Rubia Comos, Javier
González, Bernardo
Cruz-Jentoft, Alfonso J.
Iglesias, Lorena
Jarque, Isidro
Pérez Persona, Ernesto
Lluch, Rafael
Marrero, Carmen
Zudaire, Maite
Gironella, Mercedes
Hernández-Rivas, José Ángel
Arnan, Montserrat
Olivier, Carmen
Encinas, Cristina
Soler, Juan Alfonso
Ramírez Payer, Ángel
Casado, Alfonso
Fernández, Patricia
Vilanova, David
Bonanad, Santiago
author_role author
author2 González, Bernardo
Cruz-Jentoft, Alfonso J.
Iglesias, Lorena
Jarque, Isidro
Pérez Persona, Ernesto
Lluch, Rafael
Marrero, Carmen
Zudaire, Maite
Gironella, Mercedes
Hernández-Rivas, José Ángel
Arnan, Montserrat
Olivier, Carmen
Encinas, Cristina
Soler, Juan Alfonso
Ramírez Payer, Ángel
Casado, Alfonso
Fernández, Patricia
Vilanova, David
Bonanad, Santiago
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Geriatric assessment
GAH scale
Hematological malignancies
Toxicity Chemotherapy
3201.01 Oncología
topic Geriatric assessment
GAH scale
Hematological malignancies
Toxicity Chemotherapy
3201.01 Oncología
description Introduction: The GAH (Geriatric Assessment in Hematology) scale is a psychometrically valid tool aimed at identifying older patients with hematological malignancies at higher risk of treatment-related toxicity. Our objective in this study was to determine the weights for each dimension of the GAH scale and the cut-off point to reliably predict treatment tolerability in this population, estimated by a weighted receiver operating charac teristic (ROC) analysis and quantified by the area under the curve (AUC). Material and Methods: The RETROGAH was a retrospective cohort study including 126 patients who had pre viously participated in the GAH study. Patients were ≥ 65 years old with newly diagnosed myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), multiple myeloma (MM), or chronic lymphoid leukemia (CLL) and treated with standard front-line therapy within three months after having completed the GAH scale. Results: The optimal cut-off value of the GAH total score to discriminate patients at higher risk of treatment toxicity was 42, with 68.5% sensitivity and 55.8% specificity. Using this value, 66.1% of patients evaluated were found to develop some type of toxicity. The AUC was 0.6259 (95% CI: 0.512–0.739; p = 0.035). Discussion: The GAH scale not only would enable clinicians to individualize therapy based on individual risk of toxicity but also discriminate patients that will benefit most from intensive treatments from those requiring an adapted approach. While futures studies in clinical practice may improve the model and overcome its limitations, the GAH scale should not be used alone when making treatment decisions.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
2025
2025-01-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/5110
url http://hdl.handle.net/20.500.12466/5110
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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