Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry

Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, espe...

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Autores: Franco, Antonio, Moreso, Francesc, Solà Porta, Eulàlia, Beneyto, Maria Isabel, Esforzado, Núria, González-Roncero, Francisco, Sancho-Calabuig, Asunción, Melilli, Edoardo, Ruiz San Millán, Juan Carlos, Galeano, Cristina, Renal Transplantation with HCV Positive Donors Spanish Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59928
Acceso en línea:http://hdl.handle.net/10230/59928
http://dx.doi.org/10.3390/jcm12051773
Access Level:acceso abierto
Palabra clave:Kidney transplantation
Hepatitis C virus
Viremic donor
Graft outcome
Hepatocellular carcinoma
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spelling Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registryFranco, AntonioMoreso, FrancescSolà Porta, EulàliaBeneyto, Maria IsabelEsforzado, NúriaGonzález-Roncero, FranciscoSancho-Calabuig, AsunciónMelilli, EdoardoRuiz San Millán, Juan CarlosGaleano, CristinaRenal Transplantation with HCV Positive Donors Spanish Study GroupKidney transplantationHepatitis C virusViremic donorGraft outcomeHepatocellular carcinomaHistorically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8–12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised.MDPI202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59928http://dx.doi.org/10.3390/jcm12051773reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésClin Med. 2023 Feb 23;12(5):1773© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/599282026-06-12T07:21:37Z
dc.title.none.fl_str_mv Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
title Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
spellingShingle Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
Franco, Antonio
Kidney transplantation
Hepatitis C virus
Viremic donor
Graft outcome
Hepatocellular carcinoma
title_short Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
title_full Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
title_fullStr Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
title_full_unstemmed Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
title_sort Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the Spanish registry
dc.creator.none.fl_str_mv Franco, Antonio
Moreso, Francesc
Solà Porta, Eulàlia
Beneyto, Maria Isabel
Esforzado, Núria
González-Roncero, Francisco
Sancho-Calabuig, Asunción
Melilli, Edoardo
Ruiz San Millán, Juan Carlos
Galeano, Cristina
Renal Transplantation with HCV Positive Donors Spanish Study Group
author Franco, Antonio
author_facet Franco, Antonio
Moreso, Francesc
Solà Porta, Eulàlia
Beneyto, Maria Isabel
Esforzado, Núria
González-Roncero, Francisco
Sancho-Calabuig, Asunción
Melilli, Edoardo
Ruiz San Millán, Juan Carlos
Galeano, Cristina
Renal Transplantation with HCV Positive Donors Spanish Study Group
author_role author
author2 Moreso, Francesc
Solà Porta, Eulàlia
Beneyto, Maria Isabel
Esforzado, Núria
González-Roncero, Francisco
Sancho-Calabuig, Asunción
Melilli, Edoardo
Ruiz San Millán, Juan Carlos
Galeano, Cristina
Renal Transplantation with HCV Positive Donors Spanish Study Group
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Kidney transplantation
Hepatitis C virus
Viremic donor
Graft outcome
Hepatocellular carcinoma
topic Kidney transplantation
Hepatitis C virus
Viremic donor
Graft outcome
Hepatocellular carcinoma
description Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8–12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59928
http://dx.doi.org/10.3390/jcm12051773
url http://hdl.handle.net/10230/59928
http://dx.doi.org/10.3390/jcm12051773
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clin Med. 2023 Feb 23;12(5):1773
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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