The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial

Rationale. Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability...

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Autores: Chiva-Blanch, Gemma, Condines, Ximena, Magraner, Emma, Roth, Irene, Valderas-Martínez, Palmira, ARRANZ, SARA, Casas, Rosa, Martínez-Huélamo, Miriam, Vallverdu-Queralt, Anna, Quifer Rada, Paola, Lamuela-Raventos, Rosa M, Estruch Riba, Ramón
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/149520
Acceso en línea:http://hdl.handle.net/10609/149520
https://doi.org/10.1016/j.atherosclerosis.2013.12.048
Access Level:acceso abierto
Palabra clave:stromal cell derived factor 1
beer
alcohol
polyphenols
endothelial progenitor cells
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spelling The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trialChiva-Blanch, GemmaCondines, XimenaMagraner, EmmaRoth, IreneValderas-Martínez, PalmiraARRANZ, SARACasas, RosaMartínez-Huélamo, MiriamVallverdu-Queralt, AnnaQuifer Rada, PaolaLamuela-Raventos, Rosa MEstruch Riba, Ramónstromal cell derived factor 1beeralcoholpolyphenolsendothelial progenitor cellsRationale. Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability to repair and maintain endothelial integrity and function and are considered as a surrogate marker of vascular function and cumulative cardiovascular risk. Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients. Objective. To compare the effects of moderate consumption of beer, non-alcoholic beer and gin on the number of circulating EPC and EPC-mobilizing factors. Methods. In this crossover trial, 33 men at high cardiovascular risk were randomized to receive beer (30 g alcohol/d), the equivalent amount of polyphenols in the form of non-alcoholic beer, or gin (30 g alcohol/d) for 4 weeks. Diet and physical exercise were carefully monitored. Results. The number of circulating EPC and EPC-mobilizing factors were determined at baseline and after each intervention. After the beer and non-alcoholic beer interventions, the number of circulating EPC significantly increased by 8 and 5 units, respectively, while no significant differences were observed after the gin period. In correlation, stromal cell derived factor 1 increased significantly after the non-alcoholic and the beer interventions. Conclusions. The non-alcoholic fraction of beer increases the number of circulating EPC in peripheral blood from high cardiovascular risk subjects.Elsevier202420242013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10609/149520https://doi.org/10.1016/j.atherosclerosis.2013.12.048reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésAtherosclerosis, 2014, 233(2)https://doi.org/10.1016/j.atherosclerosis.2013.12.048info:eu-repo/grantAgreement/MICINN/2010/AGL2010-22319-C03CC BY-NC-NDhttp://creativecommons.org/licenses/by-nc-nd/4.0/es/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1495202026-05-28T12:42:01Z
dc.title.none.fl_str_mv The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
title The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
spellingShingle The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
Chiva-Blanch, Gemma
stromal cell derived factor 1
beer
alcohol
polyphenols
endothelial progenitor cells
title_short The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
title_full The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
title_fullStr The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
title_full_unstemmed The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
title_sort The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial
dc.creator.none.fl_str_mv Chiva-Blanch, Gemma
Condines, Ximena
Magraner, Emma
Roth, Irene
Valderas-Martínez, Palmira
ARRANZ, SARA
Casas, Rosa
Martínez-Huélamo, Miriam
Vallverdu-Queralt, Anna
Quifer Rada, Paola
Lamuela-Raventos, Rosa M
Estruch Riba, Ramón
author Chiva-Blanch, Gemma
author_facet Chiva-Blanch, Gemma
Condines, Ximena
Magraner, Emma
Roth, Irene
Valderas-Martínez, Palmira
ARRANZ, SARA
Casas, Rosa
Martínez-Huélamo, Miriam
Vallverdu-Queralt, Anna
Quifer Rada, Paola
Lamuela-Raventos, Rosa M
Estruch Riba, Ramón
author_role author
author2 Condines, Ximena
Magraner, Emma
Roth, Irene
Valderas-Martínez, Palmira
ARRANZ, SARA
Casas, Rosa
Martínez-Huélamo, Miriam
Vallverdu-Queralt, Anna
Quifer Rada, Paola
Lamuela-Raventos, Rosa M
Estruch Riba, Ramón
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv stromal cell derived factor 1
beer
alcohol
polyphenols
endothelial progenitor cells
topic stromal cell derived factor 1
beer
alcohol
polyphenols
endothelial progenitor cells
description Rationale. Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability to repair and maintain endothelial integrity and function and are considered as a surrogate marker of vascular function and cumulative cardiovascular risk. Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients. Objective. To compare the effects of moderate consumption of beer, non-alcoholic beer and gin on the number of circulating EPC and EPC-mobilizing factors. Methods. In this crossover trial, 33 men at high cardiovascular risk were randomized to receive beer (30 g alcohol/d), the equivalent amount of polyphenols in the form of non-alcoholic beer, or gin (30 g alcohol/d) for 4 weeks. Diet and physical exercise were carefully monitored. Results. The number of circulating EPC and EPC-mobilizing factors were determined at baseline and after each intervention. After the beer and non-alcoholic beer interventions, the number of circulating EPC significantly increased by 8 and 5 units, respectively, while no significant differences were observed after the gin period. In correlation, stromal cell derived factor 1 increased significantly after the non-alcoholic and the beer interventions. Conclusions. The non-alcoholic fraction of beer increases the number of circulating EPC in peripheral blood from high cardiovascular risk subjects.
publishDate 2013
dc.date.none.fl_str_mv 2013
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10609/149520
https://doi.org/10.1016/j.atherosclerosis.2013.12.048
url http://hdl.handle.net/10609/149520
https://doi.org/10.1016/j.atherosclerosis.2013.12.048
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Atherosclerosis, 2014, 233(2)
https://doi.org/10.1016/j.atherosclerosis.2013.12.048
info:eu-repo/grantAgreement/MICINN/2010/AGL2010-22319-C03
dc.rights.none.fl_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/4.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/4.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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