CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells

12 Pág. Departamento de Biotecnología

Detalhes bibliográficos
Autores: Poderoso, Teresa, Martínez De la Riva, Paloma, Álvarez, Belén, Domínguez, Javier, Ezquerra Martínez, Ángel, Revilla Calvo, Concepción
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/289636
Acesso em linha:http://hdl.handle.net/10261/289636
Access Level:acceso abierto
Palavra-chave:CD200R1
CD200R1L
Swine
Monocytes
Splicing variants
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spelling CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cellsPoderoso, TeresaMartínez De la Riva, PalomaÁlvarez, BelénDomínguez, JavierEzquerra Martínez, ÁngelRevilla Calvo, ConcepciónCD200R1CD200R1LSwineMonocytesSplicing variants12 Pág. Departamento de BiotecnologíaThe inhibitory receptor CD200R1 and its paired activating receptor CD200R1L are involved in the regulation of myeloid cell immune responses. The aim of this study was to analyze their distribution, regulation by cytokines, and function in porcine monocyte subsets. We had previously observed that CD200R1 and CD200R1L genes can generate different protein isoforms through alternative mRNA splicing, therefore in this study, we explored the diversity of transcripts in monocyte subsets, and described several new splicing variants of both CD200R1 and CD200R1L, some of which could be expressed on the porcine monocyte surface. A substantial proportion of CD163- SLAII+ and most CD163+SLAII+ monocytes expressed CD200R1 and CD200R1L receptors, while CD163- SLAII- monocytes did not. CD200R1 and CD200R1L expression was down-regulated in monocytes polarized by IFN-ɣ, a cytokine that induces classical activation of macrophages, while IL-10 which gives rise to regulatory macrophages, increased the expression of CD200R1. Finally, treatment of monocyte subsets with a monoclonal antibody specific for the inhibitory CD200R1 receptor and its splicing variants enhanced TNFα and IL-8 production, induced by TLR4 or TLR7 stimulation, suggesting a modulatory role for these receptors on porcine monocyte functions.This work was supported by grant RTA2014-00003-00-00 from INIA, Ministerio de Economía y Competitividad, Spain.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Poderoso, Teresa [0000-0002-1406-000X]Martínez De la Riva, Paloma [0000-0003-3097-022X]Domínguez, Javier [0000-0001-7256-388X]Ezquerra Martínez, Ángel [0000-0002-1824-5087]Revilla Calvo, Concepción [0000-0002-8197-4186]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/289636reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//RTA2014-00003-00-00Departamento de BiotecnologíaSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2896362026-05-22T06:33:51Z
dc.title.none.fl_str_mv CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
title CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
spellingShingle CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
Poderoso, Teresa
CD200R1
CD200R1L
Swine
Monocytes
Splicing variants
title_short CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
title_full CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
title_fullStr CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
title_full_unstemmed CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
title_sort CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells
dc.creator.none.fl_str_mv Poderoso, Teresa
Martínez De la Riva, Paloma
Álvarez, Belén
Domínguez, Javier
Ezquerra Martínez, Ángel
Revilla Calvo, Concepción
author Poderoso, Teresa
author_facet Poderoso, Teresa
Martínez De la Riva, Paloma
Álvarez, Belén
Domínguez, Javier
Ezquerra Martínez, Ángel
Revilla Calvo, Concepción
author_role author
author2 Martínez De la Riva, Paloma
Álvarez, Belén
Domínguez, Javier
Ezquerra Martínez, Ángel
Revilla Calvo, Concepción
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Poderoso, Teresa [0000-0002-1406-000X]
Martínez De la Riva, Paloma [0000-0003-3097-022X]
Domínguez, Javier [0000-0001-7256-388X]
Ezquerra Martínez, Ángel [0000-0002-1824-5087]
Revilla Calvo, Concepción [0000-0002-8197-4186]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CD200R1
CD200R1L
Swine
Monocytes
Splicing variants
topic CD200R1
CD200R1L
Swine
Monocytes
Splicing variants
description 12 Pág. Departamento de Biotecnología
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/289636
url http://hdl.handle.net/10261/289636
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//RTA2014-00003-00-00
Departamento de Biotecnología
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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