Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeost...

ver descrição completa

Detalhes bibliográficos
Autores: Almanza, Aitor, Carlesso, Antonio, Chintha, Chetan, Creedican, Stuart, Doultsinos, Dimitrios, Leuzzi, Brian, Luís, Andreia, Mccarthy, Nicole, Montibeller, Luigi, More, Sanket, Papaioannou, Alexandra, Püschel, Franziska, Sassano, Maria Livia, Skoko, Josip, Agostinis, Patrizia, Belleroche, Jackie de, Eriksson, Leif A., Fulda, Simone, Gorman, Adrienne M., Healy, Sandra, Kozlov, Andrey, Muñoz Pinedo, Cristina, Rehm, Markus, Chevet, Eric, Samali, Afshin
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174974
Acesso em linha:https://hdl.handle.net/2445/174974
Access Level:Acceso aberto
Palavra-chave:Reticle endoplasmàtic
Proteòmica
Endoplasmic reticulum
Proteomics
id ES_ccbabd41c7d1c0ccff6fb12ed767c699
oai_identifier_str oai:recercat.cat:2445/174974
network_acronym_str ES
network_name_str España
repository_id_str
spelling Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applicationsAlmanza, AitorCarlesso, AntonioChintha, ChetanCreedican, StuartDoultsinos, DimitriosLeuzzi, BrianLuís, AndreiaMccarthy, NicoleMontibeller, LuigiMore, SanketPapaioannou, AlexandraPüschel, FranziskaSassano, Maria LiviaSkoko, JosipAgostinis, PatriziaBelleroche, Jackie deEriksson, Leif A.Fulda, SimoneGorman, Adrienne M.Healy, SandraKozlov, AndreyMuñoz Pinedo, CristinaRehm, MarkusChevet, EricSamali, AfshinReticle endoplasmàticProteòmicaEndoplasmic reticulumProteomicsThe endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.Wiley2021202120182021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion39 p.application/pdfhttps://hdl.handle.net/2445/174974Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1111/febs.14608The FEBS Journal, 2018, vol. 286, num. 2, p. 241-278https://doi.org/10.1111/febs.14608info:eu-repo/grantAgreement/EC/H2020/734749info:eu-repo/grantAgreement/EC/H2020/675448cc by (c) Almanza et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1749742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
title Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
spellingShingle Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
Almanza, Aitor
Reticle endoplasmàtic
Proteòmica
Endoplasmic reticulum
Proteomics
title_short Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
title_full Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
title_fullStr Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
title_full_unstemmed Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
title_sort Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
dc.creator.none.fl_str_mv Almanza, Aitor
Carlesso, Antonio
Chintha, Chetan
Creedican, Stuart
Doultsinos, Dimitrios
Leuzzi, Brian
Luís, Andreia
Mccarthy, Nicole
Montibeller, Luigi
More, Sanket
Papaioannou, Alexandra
Püschel, Franziska
Sassano, Maria Livia
Skoko, Josip
Agostinis, Patrizia
Belleroche, Jackie de
Eriksson, Leif A.
Fulda, Simone
Gorman, Adrienne M.
Healy, Sandra
Kozlov, Andrey
Muñoz Pinedo, Cristina
Rehm, Markus
Chevet, Eric
Samali, Afshin
author Almanza, Aitor
author_facet Almanza, Aitor
Carlesso, Antonio
Chintha, Chetan
Creedican, Stuart
Doultsinos, Dimitrios
Leuzzi, Brian
Luís, Andreia
Mccarthy, Nicole
Montibeller, Luigi
More, Sanket
Papaioannou, Alexandra
Püschel, Franziska
Sassano, Maria Livia
Skoko, Josip
Agostinis, Patrizia
Belleroche, Jackie de
Eriksson, Leif A.
Fulda, Simone
Gorman, Adrienne M.
Healy, Sandra
Kozlov, Andrey
Muñoz Pinedo, Cristina
Rehm, Markus
Chevet, Eric
Samali, Afshin
author_role author
author2 Carlesso, Antonio
Chintha, Chetan
Creedican, Stuart
Doultsinos, Dimitrios
Leuzzi, Brian
Luís, Andreia
Mccarthy, Nicole
Montibeller, Luigi
More, Sanket
Papaioannou, Alexandra
Püschel, Franziska
Sassano, Maria Livia
Skoko, Josip
Agostinis, Patrizia
Belleroche, Jackie de
Eriksson, Leif A.
Fulda, Simone
Gorman, Adrienne M.
Healy, Sandra
Kozlov, Andrey
Muñoz Pinedo, Cristina
Rehm, Markus
Chevet, Eric
Samali, Afshin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Reticle endoplasmàtic
Proteòmica
Endoplasmic reticulum
Proteomics
topic Reticle endoplasmàtic
Proteòmica
Endoplasmic reticulum
Proteomics
description The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174974
url https://hdl.handle.net/2445/174974
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/febs.14608
The FEBS Journal, 2018, vol. 286, num. 2, p. 241-278
https://doi.org/10.1111/febs.14608
info:eu-repo/grantAgreement/EC/H2020/734749
info:eu-repo/grantAgreement/EC/H2020/675448
dc.rights.none.fl_str_mv cc by (c) Almanza et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Almanza et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 39 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419746005352448
score 15,811543

Registros relacionados