Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.

Background: Hepatitis E, a viral hepatitis caused mainly by the ingestion of raw or undercooked food, is not a notifiable disease in Spain.AimTo analyse the temporal trends, epidemiological characteristics and factors associated with severe disease from hepatitis E hospitalisations in Spain from 199...

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Detalhes bibliográficos
Autores: Guerrero-Vadillo, María, Peñuelas, Marina, Carmona-Alferez, Rocio, Varela Martinez, Maria del Carmen
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26243
Acesso em linha:https://hdl.handle.net/20.500.12105/26243
Access Level:acceso abierto
Palavra-chave:Electronic records
Epidemiological surveillance
Epidemiology
Hepatitis E virus
Hospitalisation
Temporal trends
Viral hepatitis
Adolescent
Adult
Age Distribution
Aged
Female
Hepatitis E
Hospitalization
Humans
Incidence
Male
Middle Aged
Risk Factors
Seasons
Sex Distribution
Spain
Young Adult
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network_acronym_str ES
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repository_id_str
spelling Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.Guerrero-Vadillo, MaríaPeñuelas, MarinaCarmona-Alferez, RocioVarela Martinez, Maria del CarmenElectronic recordsEpidemiological surveillanceEpidemiologyHepatitis E virusHospitalisationTemporal trendsViral hepatitisAdolescentAdultAge DistributionAgedFemaleHepatitis EHospitalizationHumansIncidenceMaleMiddle AgedRisk FactorsSeasonsSex DistributionSpainYoung AdultBackground: Hepatitis E, a viral hepatitis caused mainly by the ingestion of raw or undercooked food, is not a notifiable disease in Spain.AimTo analyse the temporal trends, epidemiological characteristics and factors associated with severe disease from hepatitis E hospitalisations in Spain from 1997 to 2019. Methods: Hospitalisation records were obtained from the Spanish National Hospital Discharge Database. Temporal trends and seasonality were analysed by Poisson regression in years 1997-2015 and 2016-19, given changes in hospital discharge databases. Multivariate logistic regression was used to identify factors associated with severe disease. Results: Hepatitis E hospitalisation incidence increased from 0.22 cases per 1,000,000 inhabitants in 1997 to a maximum of 2.95 in 2018. Seasonality was observed during 2016-19 period, with more cases in the second and third quarters of the year. The incidence was higher in men vs women, and in the population aged over 40 years. Factors independently associated with death were age ≥ 50 years (adjusted odds ratio (aOR): 2.43), chronic liver disease (aOR: 4.29), HIV infection (aOR: 3.00) and hepatitis B/C (aOR: 2.11). Conclusions: Hepatitis E hospitalisations have increased in Spain in recent years, being more severe in cases with older age, chronic hepatic diseases and HIV infection. A greater incidence in men over 40 years and a possible seasonality were observed. Further studies are needed to assess the seasonality, geographical distribution and impact of the disease to guide public health actions for prevention and control.European Centre for Disease Prevention and Control (ECDC)20252025-02-0320242024-10-0120242024-10-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/26243reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/262432026-06-12T12:43:37Z
dc.title.none.fl_str_mv Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
title Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
spellingShingle Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
Guerrero-Vadillo, María
Electronic records
Epidemiological surveillance
Epidemiology
Hepatitis E virus
Hospitalisation
Temporal trends
Viral hepatitis
Adolescent
Adult
Age Distribution
Aged
Female
Hepatitis E
Hospitalization
Humans
Incidence
Male
Middle Aged
Risk Factors
Seasons
Sex Distribution
Spain
Young Adult
title_short Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
title_full Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
title_fullStr Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
title_full_unstemmed Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
title_sort Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.
dc.creator.none.fl_str_mv Guerrero-Vadillo, María
Peñuelas, Marina
Carmona-Alferez, Rocio
Varela Martinez, Maria del Carmen
author Guerrero-Vadillo, María
author_facet Guerrero-Vadillo, María
Peñuelas, Marina
Carmona-Alferez, Rocio
Varela Martinez, Maria del Carmen
author_role author
author2 Peñuelas, Marina
Carmona-Alferez, Rocio
Varela Martinez, Maria del Carmen
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Electronic records
Epidemiological surveillance
Epidemiology
Hepatitis E virus
Hospitalisation
Temporal trends
Viral hepatitis
Adolescent
Adult
Age Distribution
Aged
Female
Hepatitis E
Hospitalization
Humans
Incidence
Male
Middle Aged
Risk Factors
Seasons
Sex Distribution
Spain
Young Adult
topic Electronic records
Epidemiological surveillance
Epidemiology
Hepatitis E virus
Hospitalisation
Temporal trends
Viral hepatitis
Adolescent
Adult
Age Distribution
Aged
Female
Hepatitis E
Hospitalization
Humans
Incidence
Male
Middle Aged
Risk Factors
Seasons
Sex Distribution
Spain
Young Adult
description Background: Hepatitis E, a viral hepatitis caused mainly by the ingestion of raw or undercooked food, is not a notifiable disease in Spain.AimTo analyse the temporal trends, epidemiological characteristics and factors associated with severe disease from hepatitis E hospitalisations in Spain from 1997 to 2019. Methods: Hospitalisation records were obtained from the Spanish National Hospital Discharge Database. Temporal trends and seasonality were analysed by Poisson regression in years 1997-2015 and 2016-19, given changes in hospital discharge databases. Multivariate logistic regression was used to identify factors associated with severe disease. Results: Hepatitis E hospitalisation incidence increased from 0.22 cases per 1,000,000 inhabitants in 1997 to a maximum of 2.95 in 2018. Seasonality was observed during 2016-19 period, with more cases in the second and third quarters of the year. The incidence was higher in men vs women, and in the population aged over 40 years. Factors independently associated with death were age ≥ 50 years (adjusted odds ratio (aOR): 2.43), chronic liver disease (aOR: 4.29), HIV infection (aOR: 3.00) and hepatitis B/C (aOR: 2.11). Conclusions: Hepatitis E hospitalisations have increased in Spain in recent years, being more severe in cases with older age, chronic hepatic diseases and HIV infection. A greater incidence in men over 40 years and a possible seasonality were observed. Further studies are needed to assess the seasonality, geographical distribution and impact of the disease to guide public health actions for prevention and control.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-10-01
2024
2024-10-01
2025
2025-02-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/26243
url https://hdl.handle.net/20.500.12105/26243
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv European Centre for Disease Prevention and Control (ECDC)
publisher.none.fl_str_mv European Centre for Disease Prevention and Control (ECDC)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419734950215680
score 15.81155

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