Sleep/wake cycle alterations as a cause of neurodegenerative diseases

Sleep and/or wake cycle alterations are common in neurodegenerative diseases (ND). Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease (PD) age at onset (AAO), Alzheimer's disease (AD), and amyotrophic lateral...

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Detalles Bibliográficos
Autores: Cullell, Natalia|||0000-0001-5118-1014, Cárcel-Márquez, Jara|||0000-0002-6949-0699, Gallego-Fabrega, Cristina|||0000-0003-3229-5512, Muiño, Elena|||0000-0001-5839-7328, Llucià-Carol, Laia|||0000-0002-7732-0665, Lledós, Miquel|||0000-0001-8832-789X, Amaut, K.E.U., Krupinski, J., Fernández Cadenas, Israel|||0000-0003-4821-2363
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:269621
Acceso en línea:https://ddd.uab.cat/record/269621
https://dx.doi.org/urn:doi:10.1016/j.neurobiolaging.2021.05.008
Access Level:acceso abierto
Palabra clave:Mendelian randomization
Parkinson's disease
Sleep and/or wake cycle
Alzheimer's disease
Neurodegenerative disease
Descripción
Sumario:Sleep and/or wake cycle alterations are common in neurodegenerative diseases (ND). Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease (PD) age at onset (AAO), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS)) using two-sample Mendelian Randomization (MR). We selected 12 sleep traits with available Genome-Wide Association Study (GWAS) to evaluate their causal relationship with the ND risk through Inverse-Variance Weighted regression as main analysis. We used as outcome the latest ND GWAS with available summary-statistics: PD-AAO (N = 17,996), AD (N = 21,235) and ALS (N = 40,136). MR results pointed to a causal effect of subjective and objective-measured morning chronotype on later PD-AAO (95%CI:0.33-1.81, p = 8.47×10 and 95%CI:-7.28 to -4.44, p = 5.87×10, respectively). Sleep efficiency was causally associated with a decreased AD risk (95%CI:-20.408 to -0.66, p = 0.04) and daytime sleepiness with an increased ALS risk (95%CI:0.15 to 1.61, p = 0.01). Our study suggests that sleep and/or wake patterns have causal relationship with ND. Given that sleep and/or wake patterns are modifiable risk factors, sleep interventions should be investigated as a potential treatment in PD-AAO, AD and ALS.

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