Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder

Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between senso...

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Autores: Petrus, Clara, Marcos-Vidal, Luis, Martínez-García, Magdalena, Picado, Marisol, Ramos-Quiroga, Josep Antoni, Richarte, Vanesa, Castellanos, Francisco X., Sepulcre, Jorge, Desco, Manuel, Vilarroya, Óscar, Carmona, Susanna
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/43414
Acceso en línea:http://hdl.handle.net/10230/43414
http://dx.doi.org/10.1002/hbm.24727
Access Level:acceso abierto
Palabra clave:ADHD
Adult ADHD
Default mode network
Resting-state fMRI
Stepwise functional connectivity
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spelling Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorderPetrus, ClaraMarcos-Vidal, LuisMartínez-García, MagdalenaPicado, MarisolRamos-Quiroga, Josep AntoniRicharte, VanesaCastellanos, Francisco X.Sepulcre, JorgeDesco, ManuelVilarroya, ÓscarCarmona, SusannaADHDAdult ADHDDefault mode networkResting-state fMRIStepwise functional connectivityNeuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.The authors thank the volunteers who generously contributed to this research. This work was supported by the Ministerio de Economía y Competitividad research grant (SAF2012‐32362) and the Instituto de Salud Carlos III (Miguel Servet Type I (CP16/00096), AES Grant (PI17/00064), and P‐FIS Grant (FI18/00255)).Wiley20202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43414http://dx.doi.org/10.1002/hbm.24727reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/ES/3PN/SAF2012‐32362This is the peer reviewed version of the following article: Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V. et al. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 Nov 1;40(16):4645-4656. DOI 10.1002/hbm.24727, which has been published in final form at http://dx.doi.org/10.1002/hbm.24727. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/434142026-05-29T05:05:01Z
dc.title.none.fl_str_mv Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
title Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
spellingShingle Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
Petrus, Clara
ADHD
Adult ADHD
Default mode network
Resting-state fMRI
Stepwise functional connectivity
title_short Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
title_full Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
title_fullStr Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
title_full_unstemmed Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
title_sort Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
dc.creator.none.fl_str_mv Petrus, Clara
Marcos-Vidal, Luis
Martínez-García, Magdalena
Picado, Marisol
Ramos-Quiroga, Josep Antoni
Richarte, Vanesa
Castellanos, Francisco X.
Sepulcre, Jorge
Desco, Manuel
Vilarroya, Óscar
Carmona, Susanna
author Petrus, Clara
author_facet Petrus, Clara
Marcos-Vidal, Luis
Martínez-García, Magdalena
Picado, Marisol
Ramos-Quiroga, Josep Antoni
Richarte, Vanesa
Castellanos, Francisco X.
Sepulcre, Jorge
Desco, Manuel
Vilarroya, Óscar
Carmona, Susanna
author_role author
author2 Marcos-Vidal, Luis
Martínez-García, Magdalena
Picado, Marisol
Ramos-Quiroga, Josep Antoni
Richarte, Vanesa
Castellanos, Francisco X.
Sepulcre, Jorge
Desco, Manuel
Vilarroya, Óscar
Carmona, Susanna
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADHD
Adult ADHD
Default mode network
Resting-state fMRI
Stepwise functional connectivity
topic ADHD
Adult ADHD
Default mode network
Resting-state fMRI
Stepwise functional connectivity
description Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43414
http://dx.doi.org/10.1002/hbm.24727
url http://hdl.handle.net/10230/43414
http://dx.doi.org/10.1002/hbm.24727
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/3PN/SAF2012‐32362
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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