Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition

[EN]Cdc14 belongs to a dual-specificity phosphatase family highly conserved through evolution that preferentially reverses CDK (Cyclin dependent kinases)-dependent phosphorylation events. In the yeast Saccharomyces cerevisiae, Cdc14 is an essential regulator of late mitotic stages and exit from mito...

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Detalhes bibliográficos
Autores: Sacristán Martín, María Paz, Ovejero, Sara, Bueno Núñez, Andrés Avelino
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2011
País:España
Recursos:Universidad de Salamanca (USAL)
Repositório:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/155958
Acesso em linha:http://hdl.handle.net/10366/155958
Access Level:Acceso aberto
Palavra-chave:Cell Cycle, Mitosis, Phosphatases, CDK, Cdc25, cdc14
2302.21 Biología Molecular
2407 Biología Celular
2302 Bioquímica
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spelling Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transitionSacristán Martín, María PazOvejero, SaraBueno Núñez, Andrés AvelinoCell Cycle, Mitosis, Phosphatases, CDK, Cdc25, cdc142302.21 Biología Molecular2407 Biología Celular2302 Bioquímica[EN]Cdc14 belongs to a dual-specificity phosphatase family highly conserved through evolution that preferentially reverses CDK (Cyclin dependent kinases)-dependent phosphorylation events. In the yeast Saccharomyces cerevisiae, Cdc14 is an essential regulator of late mitotic stages and exit from mitosis by counteracting CDK activity at the end of mitosis. However, many studies have shown that Cdc14 is dispensable for exiting mitosis in all other model systems analyzed. In fission yeast, the Cdc14 homolog Flp1/Clp1 regulates the stability of the mitotic inducer Cdc25 at the end of mitosis to ensure Cdk1 inactivation before cytokinesis. We have recently reported that human Cdc14A, the Cdc14 isoform located at the centrosomes during interphase, downregulates Cdc25 activity at the G2/M transition to prevent premature activation of Cdk1-Cyclin B1 complexes and untimely entry into mitosis. Here we speculate about new molecular mechanisms for Cdc14A and discuss the current evidence suggesting that Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.Taylor and Francis online202420242011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/155958reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1559582026-06-07T06:28:51Z
dc.title.none.fl_str_mv Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
title Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
spellingShingle Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
Sacristán Martín, María Paz
Cell Cycle, Mitosis, Phosphatases, CDK, Cdc25, cdc14
2302.21 Biología Molecular
2407 Biología Celular
2302 Bioquímica
title_short Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
title_full Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
title_fullStr Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
title_full_unstemmed Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
title_sort Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition
dc.creator.none.fl_str_mv Sacristán Martín, María Paz
Ovejero, Sara
Bueno Núñez, Andrés Avelino
author Sacristán Martín, María Paz
author_facet Sacristán Martín, María Paz
Ovejero, Sara
Bueno Núñez, Andrés Avelino
author_role author
author2 Ovejero, Sara
Bueno Núñez, Andrés Avelino
author2_role author
author
dc.subject.none.fl_str_mv Cell Cycle, Mitosis, Phosphatases, CDK, Cdc25, cdc14
2302.21 Biología Molecular
2407 Biología Celular
2302 Bioquímica
topic Cell Cycle, Mitosis, Phosphatases, CDK, Cdc25, cdc14
2302.21 Biología Molecular
2407 Biología Celular
2302 Bioquímica
description [EN]Cdc14 belongs to a dual-specificity phosphatase family highly conserved through evolution that preferentially reverses CDK (Cyclin dependent kinases)-dependent phosphorylation events. In the yeast Saccharomyces cerevisiae, Cdc14 is an essential regulator of late mitotic stages and exit from mitosis by counteracting CDK activity at the end of mitosis. However, many studies have shown that Cdc14 is dispensable for exiting mitosis in all other model systems analyzed. In fission yeast, the Cdc14 homolog Flp1/Clp1 regulates the stability of the mitotic inducer Cdc25 at the end of mitosis to ensure Cdk1 inactivation before cytokinesis. We have recently reported that human Cdc14A, the Cdc14 isoform located at the centrosomes during interphase, downregulates Cdc25 activity at the G2/M transition to prevent premature activation of Cdk1-Cyclin B1 complexes and untimely entry into mitosis. Here we speculate about new molecular mechanisms for Cdc14A and discuss the current evidence suggesting that Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.
publishDate 2011
dc.date.none.fl_str_mv 2011
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/155958
url http://hdl.handle.net/10366/155958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor and Francis online
publisher.none.fl_str_mv Taylor and Francis online
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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