Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.

Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small samp...

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Detalhes bibliográficos
Autores: Calvo Escalona, Rosa, Lázaro García, Luisa, Hoogman, Martine, Van Rooij, Daan, Klein, Marieke, Boedhoe, Premika S. W., Ilioska, Iva, Li, Ting, Patel, Yash, Postema, Merel C., Zhang-James, Yanli, Anagnostou, Evdokia, Arango, Celso, Auzias, Guillaume, Banaschewski, Tobias, Bau, Claiton Henrique Dotto, Behrmann, Marlene, Bellgrove, Mark A., Brandeis, Daniel, Brem, Silvia, Busatto, Geraldo F., Calderoni, Sara, Castellanos, Francisco X., Daly, Eileen, Coghill, D., Conzelmann, Annette, Deruelle, Christine, Dinstein, Illan, Durston, Sarah, Ecker, Christine, Ehrlich, Stefan, Epstein, Jeffery N., Fair, Damien, FitzGerald, Jackie, Freitag, Christine M., Frodl, Thomas, Gallagher, Louise, Grevet, Eugenio Horacio, Haavik, Jan, Ramos Quiroga, Josep Antoni
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/195260
Acesso em linha:https://hdl.handle.net/2445/195260
Access Level:acceso abierto
Palavra-chave:Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns de l'espectre autista
Escorça cerebral
Neurociències
Attention deficit disorder with hyperactivity in adults
Autism spectrum disorders
Cerebral cortex
Neurosciences
Descrição
Resumo:Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.

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