A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease

Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drugnaïvepatientshavebeendescribed,littleisknownaboutdifferencesincorticalthickness(CTh)as the diseas...

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Autores: Oltra González, Javier, Segura i Fàbregas, Bàrbara, Strafella, Antonio P., Eimeren, Thilo van, Díez Cirarda, María, Ibarretxe Bilbao, Naroa, Monté Rubio, Gemma C., Ojeda, Natalia, Peña Lasa, Javier, Eggers, Carsten, Lucas Jiménez, Olaia, Ruppert, Marina C., Sala Llonch, Roser, Theis, Hendrik, Uribe, Carme, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222959
Acceso en línea:https://hdl.handle.net/2445/222959
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Parkinson's disease
Sex factors in disease
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spelling A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s diseaseOltra González, JavierSegura i Fàbregas, BàrbaraStrafella, Antonio P.Eimeren, Thilo vanDíez Cirarda, MaríaIbarretxe Bilbao, NaroaMonté Rubio, Gemma C.Ojeda, NataliaPeña Lasa, JavierEggers, CarstenLucas Jiménez, OlaiaRuppert, Marina C.Sala Llonch, RoserTheis, HendrikUribe, CarmeJunqué i Plaja, Carme, 1955-Malaltia de ParkinsonParkinson's diseaseSex factors in diseaseClinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drugnaïvepatientshavebeendescribed,littleisknownaboutdifferencesincorticalthickness(CTh)as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58±8.44 years old; mean disease duration 6.42±5.11 years) and 86 healthy controls (50% males; mean age 65.49±9.33years old) with available T1-weighted 3T MRI datafrom four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showedthinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), andonelimbicregion(right posterior cingulate).In PDmales,lowerCThvaluesinnine outoftenregionswereassociatedwithlongerdiseasedurationandolderage,whereasinPDfemales, lower CThwasassociatedwith older agebut with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site dataSpringer NatureFactors sexuals en les malalties2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222959Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41531-024-00686-2npj Parkinson's Disease, 2024, vol. 10, num.69https://doi.org/10.1038/s41531-024-00686-2cc-by (c) Oltra J et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2229592026-05-27T06:46:51Z
dc.title.none.fl_str_mv A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
title A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
spellingShingle A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
Oltra González, Javier
Malaltia de Parkinson
Parkinson's disease
Sex factors in disease
title_short A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
title_full A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
title_fullStr A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
title_full_unstemmed A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
title_sort A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
dc.creator.none.fl_str_mv Oltra González, Javier
Segura i Fàbregas, Bàrbara
Strafella, Antonio P.
Eimeren, Thilo van
Díez Cirarda, María
Ibarretxe Bilbao, Naroa
Monté Rubio, Gemma C.
Ojeda, Natalia
Peña Lasa, Javier
Eggers, Carsten
Lucas Jiménez, Olaia
Ruppert, Marina C.
Sala Llonch, Roser
Theis, Hendrik
Uribe, Carme
Junqué i Plaja, Carme, 1955-
author Oltra González, Javier
author_facet Oltra González, Javier
Segura i Fàbregas, Bàrbara
Strafella, Antonio P.
Eimeren, Thilo van
Díez Cirarda, María
Ibarretxe Bilbao, Naroa
Monté Rubio, Gemma C.
Ojeda, Natalia
Peña Lasa, Javier
Eggers, Carsten
Lucas Jiménez, Olaia
Ruppert, Marina C.
Sala Llonch, Roser
Theis, Hendrik
Uribe, Carme
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Strafella, Antonio P.
Eimeren, Thilo van
Díez Cirarda, María
Ibarretxe Bilbao, Naroa
Monté Rubio, Gemma C.
Ojeda, Natalia
Peña Lasa, Javier
Eggers, Carsten
Lucas Jiménez, Olaia
Ruppert, Marina C.
Sala Llonch, Roser
Theis, Hendrik
Uribe, Carme
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Factors sexuals en les malalties
dc.subject.none.fl_str_mv Malaltia de Parkinson
Parkinson's disease
Sex factors in disease
topic Malaltia de Parkinson
Parkinson's disease
Sex factors in disease
description Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drugnaïvepatientshavebeendescribed,littleisknownaboutdifferencesincorticalthickness(CTh)as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58±8.44 years old; mean disease duration 6.42±5.11 years) and 86 healthy controls (50% males; mean age 65.49±9.33years old) with available T1-weighted 3T MRI datafrom four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showedthinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), andonelimbicregion(right posterior cingulate).In PDmales,lowerCThvaluesinnine outoftenregionswereassociatedwithlongerdiseasedurationandolderage,whereasinPDfemales, lower CThwasassociatedwith older agebut with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site data
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222959
url https://hdl.handle.net/2445/222959
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41531-024-00686-2
npj Parkinson's Disease, 2024, vol. 10, num.69
https://doi.org/10.1038/s41531-024-00686-2
dc.rights.none.fl_str_mv cc-by (c) Oltra J et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Oltra J et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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