Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar

6 pages, 7 figures.-- PMID: 12533665 [PubMed].-- PMCID: PMC298683.-- Printed version published Feb 4, 2003.-- Full text version available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298683/?tool=pubmed

Detalles Bibliográficos
Autores: Jurenka, Russell A., Subchev, Mitko, Abad, José Luis, Choi, Man-Yeon, Fabriàs, Gemma
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/20119
Acceso en línea:http://hdl.handle.net/10261/20119
Access Level:acceso abierto
Palabra clave:Sex pheromone
Female moths
Biosynthetic pathway
Lymantria dispar
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spelling Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria disparJurenka, Russell A.Subchev, MitkoAbad, José LuisChoi, Man-YeonFabriàs, GemmaSex pheromoneFemale mothsBiosynthetic pathwayLymantria dispar6 pages, 7 figures.-- PMID: 12533665 [PubMed].-- PMCID: PMC298683.-- Printed version published Feb 4, 2003.-- Full text version available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298683/?tool=pubmedThe pheromone biosynthetic pathway for production of the sex pheromone disparlure, 2-methyl-7R,8S-epoxy-octadecane, was determined for the gypsy moth. Each step in the pathway was followed by using deuterium-labeled compounds that could be identified by using GC/MS. This approach provides unequivocal determination of specific reactions in the pathway. It was shown that the alkene precursor, 2-methyl-Z7-octadecene, is most likely made in oenocyte cells associated with abdominal epidermal cells. The pathway begins with valine contributing carbons for chain initiation, including the methyl-branched carbon, followed by chain elongation to 19 carbons. The double bond is introduced with an unusual Δ12 desaturase that utilizes a methyl-branched substrate. The resulting 18-methyl-Z12-nonadecenoate is decarboxylated to the hydrocarbon, 2-methyl-Z7-octadecene. The alkene is then transported to the pheromone gland through the hemolymph, most probably by lipophorin. At the pheromone gland, the alkene is unloaded and transformed into the epoxide disparlure for release into the environment. A chiral HPLC column was used to demonstrate that the (R,S)-stereoisomer of the epoxide, (+)-disparlure is found in pheromone glands.This work was supported by grants from the U.S. Department of Agriculture–National Research Initiative (2001-35302-10882) and the U.S.–Spain Joint Commission on Scientific and Technological Cooperation, and by Hatch Act and State of Iowa funds.Peer reviewedNational Academy of Sciences (U.S.)201020102003info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_650122195 bytesapplication/pdfhttp://hdl.handle.net/10261/20119reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.0236060100info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/201192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
title Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
spellingShingle Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
Jurenka, Russell A.
Sex pheromone
Female moths
Biosynthetic pathway
Lymantria dispar
title_short Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
title_full Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
title_fullStr Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
title_full_unstemmed Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
title_sort Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
dc.creator.none.fl_str_mv Jurenka, Russell A.
Subchev, Mitko
Abad, José Luis
Choi, Man-Yeon
Fabriàs, Gemma
author Jurenka, Russell A.
author_facet Jurenka, Russell A.
Subchev, Mitko
Abad, José Luis
Choi, Man-Yeon
Fabriàs, Gemma
author_role author
author2 Subchev, Mitko
Abad, José Luis
Choi, Man-Yeon
Fabriàs, Gemma
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sex pheromone
Female moths
Biosynthetic pathway
Lymantria dispar
topic Sex pheromone
Female moths
Biosynthetic pathway
Lymantria dispar
description 6 pages, 7 figures.-- PMID: 12533665 [PubMed].-- PMCID: PMC298683.-- Printed version published Feb 4, 2003.-- Full text version available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298683/?tool=pubmed
publishDate 2003
dc.date.none.fl_str_mv 2003
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/20119
url http://hdl.handle.net/10261/20119
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.0236060100
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22195 bytes
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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