ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

Arconada Luque, Elena; Jiménez-Suarez, Jaime; Pascual-Serra, Raquel; Nam-Cha, Syong Hyun; Moline Marimon, Teresa; Cimas, Francisco J.; Fliquete, German; Hernandez Losa, Javier; Ramon y Cajal Agüeras, Santiago

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

ERK5; Leiomyosarcoma; Soft tissue sarcoma

Detalles Bibliográficos
Autores:	Arconada Luque, Elena, Jiménez-Suarez, Jaime, Pascual-Serra, Raquel, Nam-Cha, Syong Hyun, Moline Marimon, Teresa, Cimas, Francisco J., Fliquete, German, Hernandez Losa, Javier, Ramon y Cajal Agüeras, Santiago
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:11351/8285
Acceso en línea:	https://hdl.handle.net/11351/8285 http://hdl.handle.net/11351/8285
Access Level:	acceso abierto
Palabra clave:	Sarcoma - Tractament Sarcoma - Diagnòstic Cèl·lules canceroses DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms Other subheadings::Other subheadings::/diagnosis DISEASES::Neoplasms Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/terapia

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dc.title.none.fl_str_mv	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
title	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
spellingShingle	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology Arconada Luque, Elena Sarcoma - Tractament Sarcoma - Diagnòstic Cèl·lules canceroses DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms Other subheadings::Other subheadings::/diagnosis DISEASES::Neoplasms Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/terapia
title_short	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
title_full	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
title_fullStr	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
title_full_unstemmed	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
title_sort	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology
dc.creator.none.fl_str_mv	Arconada Luque, Elena Jiménez-Suarez, Jaime Pascual-Serra, Raquel Nam-Cha, Syong Hyun Moline Marimon, Teresa Cimas, Francisco J. Fliquete, German Hernandez Losa, Javier Ramon y Cajal Agüeras, Santiago
author	Arconada Luque, Elena
author_facet	Arconada Luque, Elena Jiménez-Suarez, Jaime Pascual-Serra, Raquel Nam-Cha, Syong Hyun Moline Marimon, Teresa Cimas, Francisco J. Fliquete, German Hernandez Losa, Javier Ramon y Cajal Agüeras, Santiago
author_role	author
author2	Jiménez-Suarez, Jaime Pascual-Serra, Raquel Nam-Cha, Syong Hyun Moline Marimon, Teresa Cimas, Francisco J. Fliquete, German Hernandez Losa, Javier Ramon y Cajal Agüeras, Santiago
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv	Institut Català de la Salut [Arconada-Luque E, Jiménez-Suarez J, Pascual-Serra R] Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Unidad Asociada de Biomedicina UCLM, Unidad Asociada al CSIC, Universidad de Castilla-La Mancha, Albacete, Spain. [Nam-Cha SH] Servicio de Anatomía Patológica, Hospital General de Albacete, Albacete, Spain. [Moline T, Fliquete G, Hernández-Losa J, Ramón Y Cajal S] Grup de Recerca en Patologia Molecular Traslacional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en RED de Cáncer CIBERONC, Barcelona, Spain. [Cimas FJ] Unidad de Bioquímica y Biología Molecular, Servicio de Instrumentación Biomédica, Universidad de Castilla-La Mancha, Albacete, Spain Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv	Sarcoma - Tractament Sarcoma - Diagnòstic Cèl·lules canceroses DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms Other subheadings::Other subheadings::/diagnosis DISEASES::Neoplasms Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/terapia
topic	Sarcoma - Tractament Sarcoma - Diagnòstic Cèl·lules canceroses DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms Other subheadings::Other subheadings::/diagnosis DISEASES::Neoplasms Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/terapia
description	ERK5; Leiomyosarcoma; Soft tissue sarcoma
publishDate	2022
dc.date.none.fl_str_mv	2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/11351/8285 http://hdl.handle.net/11351/8285
url	https://hdl.handle.net/11351/8285 http://hdl.handle.net/11351/8285
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Cancers;14(14) https://doi.org/10.3390/cancers14143509
dc.rights.none.fl_str_mv	Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human PathologyArconada Luque, ElenaJiménez-Suarez, JaimePascual-Serra, RaquelNam-Cha, Syong HyunMoline Marimon, TeresaCimas, Francisco J.Fliquete, GermanHernandez Losa, JavierRamon y Cajal Agüeras, SantiagoSarcoma - TractamentSarcoma - DiagnòsticCèl·lules cancerosesDISEASES::Neoplasms::Neoplasms by Site::Soft Tissue NeoplasmsOther subheadings::Other subheadings::/diagnosisDISEASES::NeoplasmsOther subheadings::Other subheadings::/therapyENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandosOtros calificadores::Otros calificadores::/diagnósticoENFERMEDADES::neoplasiasOtros calificadores::Otros calificadores::/terapiaERK5; Leiomyosarcoma; Soft tissue sarcomaERK5; Leiomiosarcoma; Sarcoma de tejido blandoERK5; Leiomiosarcoma; Sarcoma dels teixits tousSarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, showing an increased expression of ERK5. Indeed, this upregulation was also observed in human sarcomas of muscular origin, such as leiomyosarcoma or rhabdomyosarcoma. Moreover, in cell lines derived from these 3MC-induced tumors, abrogation of Mapk7 expression by using specific shRNAs decreased in vitro growth and colony-forming capacity and led to a marked loss of tumor growth in vivo. In fact, transcriptomic profiling in ERK5 abrogated cell lines by RNAseq showed a deregulated gene expression pattern for key biological processes such as angiogenesis, migration, motility, etc., correlating with a better prognostic in human pathology. Finally, among the various differentially expressed genes, Klf2 is a key mediator of the biological effects of ERK5 as indicated by its specific interference, demonstrating that the ERK5–KLF2 axis is an important determinant of sarcoma biology that should be further studied in human pathology.This work has been supported with Grant RTI2018-094093-B-I00 funded by MCIN/AEI/10.13039/501100011033, “ERDF A way of making Europe” to RSP. Also supported with funds from Fundación Leticia Castillejo Castillo, Roche España and ACEPAIN to RSP and MJRH. RSP and MJRH’s Research Institute and the work carried out in their laboratory, received partial support from the European Community through the FEDER. JJ and EAL hold a predoctoral research contract cofounded by the European Social Fund and UCLM. OR holds a contract for accessing the Spanish System of Science, Technology, and Innovation (SECTI) funded by the University of Castilla-La Mancha (UCLM) and received partial support from the European Social Fund (FSE) through its Operative Program for Castilla-La Mancha (2007–2013).MDPIInstitut Català de la Salut[Arconada-Luque E, Jiménez-Suarez J, Pascual-Serra R] Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Unidad Asociada de Biomedicina UCLM, Unidad Asociada al CSIC, Universidad de Castilla-La Mancha, Albacete, Spain. [Nam-Cha SH] Servicio de Anatomía Patológica, Hospital General de Albacete, Albacete, Spain. [Moline T, Fliquete G, Hernández-Losa J, Ramón Y Cajal S] Grup de Recerca en Patologia Molecular Traslacional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en RED de Cáncer CIBERONC, Barcelona, Spain. [Cimas FJ] Unidad de Bioquímica y Biología Molecular, Servicio de Instrumentación Biomédica, Universidad de Castilla-La Mancha, Albacete, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8285http://hdl.handle.net/11351/8285Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancers;14(14)https://doi.org/10.3390/cancers14143509Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/82852026-05-29T05:05:01Z
score	15,812429

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

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