The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL

Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before a...

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Autores: Keller, Theresa, Hohmann, Cynthia, Standl, Marie, Wijga, Alet, Gehring, Ulrike, Melén, Erik, Almqvist, Catarina, Lau, Susanne, Eller, Esben, Wahn, Ulrich, Christiansen, E.S., von Berg, Andrea, Heinrich, Joachim, Lehmann, Irina, Maier, Dieter, Postma, Dirkje S., Antó i Boqué, Josep Maria, Bousquet, Jean, Keil, Thomas, Roll, Stephanie
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/35629
Acceso en línea:http://hdl.handle.net/10230/35629
http://dx.doi.org/10.1111/all.13312
Access Level:acceso abierto
Palabra clave:Asthma
Birth cohort
Puberty
Rhinitis
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spelling The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALLKeller, TheresaHohmann, CynthiaStandl, MarieWijga, AletGehring, UlrikeMelén, ErikAlmqvist, CatarinaLau, SusanneEller, EsbenWahn, UlrichChristiansen, E.S.von Berg, AndreaHeinrich, JoachimLehmann, IrinaMaier, DieterPostma, Dirkje S.Antó i Boqué, Josep MariaBousquet, JeanKeil, ThomasRoll, StephanieAsthmaBirth cohortPubertyRhinitisBackground - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.European Union under the Health Cooperation Work Programme of the 7th Framework Programme. Grant Number: 261357Wiley201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35629http://dx.doi.org/10.1111/all.13312reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAllergy. 2018;73(3):602-14info:eu-repo/grantAgreement/EC/FP7/261357© 2017 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/356292026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
title The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
spellingShingle The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
Keller, Theresa
Asthma
Birth cohort
Puberty
Rhinitis
title_short The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
title_full The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
title_fullStr The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
title_full_unstemmed The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
title_sort The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
dc.creator.none.fl_str_mv Keller, Theresa
Hohmann, Cynthia
Standl, Marie
Wijga, Alet
Gehring, Ulrike
Melén, Erik
Almqvist, Catarina
Lau, Susanne
Eller, Esben
Wahn, Ulrich
Christiansen, E.S.
von Berg, Andrea
Heinrich, Joachim
Lehmann, Irina
Maier, Dieter
Postma, Dirkje S.
Antó i Boqué, Josep Maria
Bousquet, Jean
Keil, Thomas
Roll, Stephanie
author Keller, Theresa
author_facet Keller, Theresa
Hohmann, Cynthia
Standl, Marie
Wijga, Alet
Gehring, Ulrike
Melén, Erik
Almqvist, Catarina
Lau, Susanne
Eller, Esben
Wahn, Ulrich
Christiansen, E.S.
von Berg, Andrea
Heinrich, Joachim
Lehmann, Irina
Maier, Dieter
Postma, Dirkje S.
Antó i Boqué, Josep Maria
Bousquet, Jean
Keil, Thomas
Roll, Stephanie
author_role author
author2 Hohmann, Cynthia
Standl, Marie
Wijga, Alet
Gehring, Ulrike
Melén, Erik
Almqvist, Catarina
Lau, Susanne
Eller, Esben
Wahn, Ulrich
Christiansen, E.S.
von Berg, Andrea
Heinrich, Joachim
Lehmann, Irina
Maier, Dieter
Postma, Dirkje S.
Antó i Boqué, Josep Maria
Bousquet, Jean
Keil, Thomas
Roll, Stephanie
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asthma
Birth cohort
Puberty
Rhinitis
topic Asthma
Birth cohort
Puberty
Rhinitis
description Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35629
http://dx.doi.org/10.1111/all.13312
url http://hdl.handle.net/10230/35629
http://dx.doi.org/10.1111/all.13312
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Allergy. 2018;73(3):602-14
info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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