On qualitative properties of replication and transfer of conjugative plasmids encoding antibiotic resistance genes
In order to advance in the fight against plasmid-mediated resistance, it is necessary to deepen our understanding of the role played by these DNA molecules. In this sense, the achievements obtained from experimentation validated by mathematical models have contributed to the discovery of key propert...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/42473 |
| Acceso en línea: | https://hdl.handle.net/10347/42473 |
| Access Level: | acceso abierto |
| Palabra clave: | Plasmid-mediated antibiotic resistance Mathematical model Plasmid replication Plasmid transfer Qualitative analysis |
| Sumario: | In order to advance in the fight against plasmid-mediated resistance, it is necessary to deepen our understanding of the role played by these DNA molecules. In this sense, the achievements obtained from experimentation validated by mathematical models have contributed to the discovery of key properties in the dynamics of antibiotic resistance. In this work, we attempt to characterize some of these properties through nonlinear functional responses of both plasmid replication and plasmid transfer. The results of the mathematical modeling performed here suggest that the emergence of antibiotic resistance in an individual due to the transfer of plasmid-borne resistance genes is directly associated with the production capacity of both recipient and donor bacteria. Whereas for persistence, in addition to bacterial replication, specific properties associated with plasmid replication and transfer are required. |
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