The Phylum Bryozoa as a promising source of anticancer drugs

Recent advances in sampling and novel techniques in drug synthesis and isolation have promoted the discovery of anticancer agents from marine organisms to combat this major threat to public health worldwide. Bryozoans, which are filter-feeding, aquatic invertebrates often characterized by a calcifie...

ver descrição completa

Detalhes bibliográficos
Autores: Figuerola Balañá, Blanca, Ávila Escartín, Conxita
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/149902
Acesso em linha:https://hdl.handle.net/2445/149902
Access Level:Acceso aberto
Palavra-chave:Briozous
Càncer
Bryozoa
Cancer
id ES_cc32f9f617bf7a4db9db3d83e0211cb7
oai_identifier_str oai:diposit.ub.edu:2445/149902
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Phylum Bryozoa as a promising source of anticancer drugsFiguerola Balañá, BlancaÁvila Escartín, ConxitaBriozousCàncerBryozoaCancerRecent advances in sampling and novel techniques in drug synthesis and isolation have promoted the discovery of anticancer agents from marine organisms to combat this major threat to public health worldwide. Bryozoans, which are filter-feeding, aquatic invertebrates often characterized by a calcified skeleton, are an excellent source of pharmacologically interesting compounds including well-known chemical classes such as alkaloids and polyketides. This review covers the literature for secondary metabolites isolated from marine cheilostome and ctenostome bryozoans that have shown potential as cancer drugs. Moreover, we highlight examples such as bryostatins, the most known class of marine-derived compounds from this animal phylum, which are advancing through anticancer clinical trials due to their low toxicity and antineoplastic activity. The bryozoan antitumor compounds discovered until now show a wide range of chemical diversity and biological activities. Therefore, more research focusing on the isolation of secondary metabolites with potential anticancer properties from bryozoans and other overlooked taxa covering wider geographic areas is needed for an efficient bioprospecting of natural products.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/149902Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/md17080477Marine Drugs, 2019, vol. 17, num. 8, p. 477-500https://doi.org/10.3390/md17080477cc-by (c) Figuerola, Blanca et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1499022026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Phylum Bryozoa as a promising source of anticancer drugs
title The Phylum Bryozoa as a promising source of anticancer drugs
spellingShingle The Phylum Bryozoa as a promising source of anticancer drugs
Figuerola Balañá, Blanca
Briozous
Càncer
Bryozoa
Cancer
title_short The Phylum Bryozoa as a promising source of anticancer drugs
title_full The Phylum Bryozoa as a promising source of anticancer drugs
title_fullStr The Phylum Bryozoa as a promising source of anticancer drugs
title_full_unstemmed The Phylum Bryozoa as a promising source of anticancer drugs
title_sort The Phylum Bryozoa as a promising source of anticancer drugs
dc.creator.none.fl_str_mv Figuerola Balañá, Blanca
Ávila Escartín, Conxita
author Figuerola Balañá, Blanca
author_facet Figuerola Balañá, Blanca
Ávila Escartín, Conxita
author_role author
author2 Ávila Escartín, Conxita
author2_role author
dc.subject.none.fl_str_mv Briozous
Càncer
Bryozoa
Cancer
topic Briozous
Càncer
Bryozoa
Cancer
description Recent advances in sampling and novel techniques in drug synthesis and isolation have promoted the discovery of anticancer agents from marine organisms to combat this major threat to public health worldwide. Bryozoans, which are filter-feeding, aquatic invertebrates often characterized by a calcified skeleton, are an excellent source of pharmacologically interesting compounds including well-known chemical classes such as alkaloids and polyketides. This review covers the literature for secondary metabolites isolated from marine cheilostome and ctenostome bryozoans that have shown potential as cancer drugs. Moreover, we highlight examples such as bryostatins, the most known class of marine-derived compounds from this animal phylum, which are advancing through anticancer clinical trials due to their low toxicity and antineoplastic activity. The bryozoan antitumor compounds discovered until now show a wide range of chemical diversity and biological activities. Therefore, more research focusing on the isolation of secondary metabolites with potential anticancer properties from bryozoans and other overlooked taxa covering wider geographic areas is needed for an efficient bioprospecting of natural products.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/149902
url https://hdl.handle.net/2445/149902
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/md17080477
Marine Drugs, 2019, vol. 17, num. 8, p. 477-500
https://doi.org/10.3390/md17080477
dc.rights.none.fl_str_mv cc-by (c) Figuerola, Blanca et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Figuerola, Blanca et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419677020585984
score 15.300719

Registros relacionados