Coarse-graining the vertex model and its response to shear
Tissue dynamics and collective cell motion are crucial biological processes. Their biological machinery is mostly known, and simulation models such as the active vertex model exist and yield reasonable agreement with experimental observations such as tissue fluidization or fingering. However, a good...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/348864 |
| Acceso en línea: | http://hdl.handle.net/10261/348864 http://arxiv.org/abs/2302.04111v1 |
| Access Level: | acceso abierto |
| Palabra clave: | Physics - Soft Condensed Matter Quantitative Biology - Tissues and Organs |
| Sumario: | Tissue dynamics and collective cell motion are crucial biological processes. Their biological machinery is mostly known, and simulation models such as the active vertex model exist and yield reasonable agreement with experimental observations such as tissue fluidization or fingering. However, a good and well-founded continuum description for tissues remains to be developed. In this work, we derive a macroscopic description for a two-dimensional cell monolayer by coarse-graining the vertex model through the Poisson bracket approach. We obtain equations for cell density, velocity, and the cellular shape tensor. We then study the homogeneous steady states, their stability (which coincides with thermodynamic stability), and especially their behavior under an externally applied shear. Our results contribute to elucidate the interplay between flow and cellular shape. The obtained macroscopic equations present a good starting point for adding cell motion, morphogenetic, and other biologically relevant processes. |
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