The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users

Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphis...

Descripción completa

Detalles Bibliográficos
Autores: Batalla, Albert, Lorenzetti, Valentina, Chye ,Yann, Yucel, Murat, Soriano Mas, Carles, Bhattacharyya, Sagnik, Torrens, Marta, Crippa, José A.S., Martín Santos, Rocío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/35630
Acceso en línea:http://hdl.handle.net/10230/35630
http://dx.doi.org/10.1089/can.2017.0021
Access Level:acceso abierto
Palabra clave:Hipocamp (Cervell)
Cannabis -- Efectes secundaris
Brain-derived neurotrophic factor
Cannabis
Catechol-O-methyltransferase gene
Dopamine transporter gene
Hippocampal subfields
Hippocampus
id ES_cc2c95c547c4fa900d7a3c3cfc907e7b
oai_identifier_str oai:recercat.cat:10230/35630
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis UsersBatalla, AlbertLorenzetti, ValentinaChye ,YannYucel, MuratSoriano Mas, CarlesBhattacharyya, SagnikTorrens, MartaCrippa, José A.S.Martín Santos, RocíoHipocamp (Cervell)Cannabis -- Efectes secundarisBrain-derived neurotrophic factorCannabisCatechol-O-methyltransferase geneDopamine transporter geneHippocampal subfieldsHippocampusIntroduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years. These included 30 chronic cannabis users with early-onset (regular use at <16 years) and 29 age-, education-, and intelligence-matched controls. Results: Cannabis use and dopaminergic gene polymorphism had both distinct and interactive effects on the hippocampus. We found emerging alterations of hippocampal total and specific subregional volumes in cannabis users relative to controls (i.e., CA1, CA2/3, and CA4), and associations between cannabis use levels and total and specific subregional volumes. Furthermore, total hippocampal volume and the fissure subregion were affected by cannabis×DAT1 polymorphism (i.e., 9/9R and in 10/10R alleles), reflecting high and low levels of dopamine availability. Conclusion: These findings suggest that cannabis exposure alters the normal relationship between DAT1 polymorphism and the anatomy of total and subregional hippocampal volumes, and that specific hippocampal subregions may be particularly affected.Mary Ann Liebert201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35630http://dx.doi.org/10.1089/can.2017.0021reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCannabis and Cannabinoid Research. 2018 Feb 1;3(1):1-10Copyright © Albert Batalla et al. 2018; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/356302026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
title The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
spellingShingle The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
Batalla, Albert
Hipocamp (Cervell)
Cannabis -- Efectes secundaris
Brain-derived neurotrophic factor
Cannabis
Catechol-O-methyltransferase gene
Dopamine transporter gene
Hippocampal subfields
Hippocampus
title_short The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
title_full The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
title_fullStr The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
title_full_unstemmed The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
title_sort The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users
dc.creator.none.fl_str_mv Batalla, Albert
Lorenzetti, Valentina
Chye ,Yann
Yucel, Murat
Soriano Mas, Carles
Bhattacharyya, Sagnik
Torrens, Marta
Crippa, José A.S.
Martín Santos, Rocío
author Batalla, Albert
author_facet Batalla, Albert
Lorenzetti, Valentina
Chye ,Yann
Yucel, Murat
Soriano Mas, Carles
Bhattacharyya, Sagnik
Torrens, Marta
Crippa, José A.S.
Martín Santos, Rocío
author_role author
author2 Lorenzetti, Valentina
Chye ,Yann
Yucel, Murat
Soriano Mas, Carles
Bhattacharyya, Sagnik
Torrens, Marta
Crippa, José A.S.
Martín Santos, Rocío
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hipocamp (Cervell)
Cannabis -- Efectes secundaris
Brain-derived neurotrophic factor
Cannabis
Catechol-O-methyltransferase gene
Dopamine transporter gene
Hippocampal subfields
Hippocampus
topic Hipocamp (Cervell)
Cannabis -- Efectes secundaris
Brain-derived neurotrophic factor
Cannabis
Catechol-O-methyltransferase gene
Dopamine transporter gene
Hippocampal subfields
Hippocampus
description Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years. These included 30 chronic cannabis users with early-onset (regular use at <16 years) and 29 age-, education-, and intelligence-matched controls. Results: Cannabis use and dopaminergic gene polymorphism had both distinct and interactive effects on the hippocampus. We found emerging alterations of hippocampal total and specific subregional volumes in cannabis users relative to controls (i.e., CA1, CA2/3, and CA4), and associations between cannabis use levels and total and specific subregional volumes. Furthermore, total hippocampal volume and the fissure subregion were affected by cannabis×DAT1 polymorphism (i.e., 9/9R and in 10/10R alleles), reflecting high and low levels of dopamine availability. Conclusion: These findings suggest that cannabis exposure alters the normal relationship between DAT1 polymorphism and the anatomy of total and subregional hippocampal volumes, and that specific hippocampal subregions may be particularly affected.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35630
http://dx.doi.org/10.1089/can.2017.0021
url http://hdl.handle.net/10230/35630
http://dx.doi.org/10.1089/can.2017.0021
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cannabis and Cannabinoid Research. 2018 Feb 1;3(1):1-10
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419675221229568
score 15,812429

Similares en LA Referencia