Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study

[Background and purpose]: Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms...

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Autores: Albillos, Silvia M., Montero, Olimpio, Calvo, Sara, Solano, Berta, Trejo-Gabriel-Galán, José María, Cubo, Esther
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260836
Acceso en línea:http://hdl.handle.net/10261/260836
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Essential tremor
Plasma biomarkers
Bilirubin
Acyl-carnitines
Tyramine
Tetrahydro-21-deoxycortisol
Motor skills disorders
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spelling Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker studyAlbillos, Silvia M.Montero, OlimpioCalvo, SaraSolano, BertaTrejo-Gabriel-Galán, José MaríaCubo, EstherParkinson's diseaseEssential tremorPlasma biomarkersBilirubinAcyl-carnitinesTyramineTetrahydro-21-deoxycortisolMotor skills disorders[Background and purpose]: Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms (NMS) in patients with PD, and to determine differences between de novo PD compared to moderate-advanced PD vs. controls and patients with ET.[Methods]: Plasma samples were collected from 137 subjects including 35 age matched controls, 29 NOVO-PD, 35 PD and 38 ET patients. PD severity, motor and NMS including cognitive function were assessed using the UPDRS, NMS and PD cognitive rating scales, respectively. Metabolomics analysis was performed by UPLC-ESI-QToF-MS followed by unsupervised multivariate statistics. The area under the curve of the biomarkers according to distribution of their concentrations and the diagnosis of PD (NOVO-PD, advanced PD) vs ET and healthy controls was used as a measurement of diagnostic ability.[Results]: Several acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol (THS) presented good predictive accuracy (AUC higher than 0.8) for differentiating de novo PD and advanced PD from controls and ET, suggesting an alteration in the lipid oxidation pathway. In multivariate regression analysis, metabolite levels were not significantly associated with motor and NMS severity in PD.[Conclusions]: Diverse acyl-carnitines, bilirubin, tyramine and some adrenal gland derived metabolites are suggested as potential biomarkers able to distinguish between PD from controls and ET.This work was supported by Junta de Castilla y León (BIO/BU06/14).Elsevier BVJunta de Castilla y LeónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/260836reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.parkreldis.2021.09.014Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2608362026-05-22T06:33:51Z
dc.title.none.fl_str_mv Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
title Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
spellingShingle Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
Albillos, Silvia M.
Parkinson's disease
Essential tremor
Plasma biomarkers
Bilirubin
Acyl-carnitines
Tyramine
Tetrahydro-21-deoxycortisol
Motor skills disorders
title_short Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
title_full Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
title_fullStr Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
title_full_unstemmed Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
title_sort Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study
dc.creator.none.fl_str_mv Albillos, Silvia M.
Montero, Olimpio
Calvo, Sara
Solano, Berta
Trejo-Gabriel-Galán, José María
Cubo, Esther
author Albillos, Silvia M.
author_facet Albillos, Silvia M.
Montero, Olimpio
Calvo, Sara
Solano, Berta
Trejo-Gabriel-Galán, José María
Cubo, Esther
author_role author
author2 Montero, Olimpio
Calvo, Sara
Solano, Berta
Trejo-Gabriel-Galán, José María
Cubo, Esther
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Castilla y León
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Parkinson's disease
Essential tremor
Plasma biomarkers
Bilirubin
Acyl-carnitines
Tyramine
Tetrahydro-21-deoxycortisol
Motor skills disorders
topic Parkinson's disease
Essential tremor
Plasma biomarkers
Bilirubin
Acyl-carnitines
Tyramine
Tetrahydro-21-deoxycortisol
Motor skills disorders
description [Background and purpose]: Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms (NMS) in patients with PD, and to determine differences between de novo PD compared to moderate-advanced PD vs. controls and patients with ET.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260836
url http://hdl.handle.net/10261/260836
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.parkreldis.2021.09.014
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419638664724480
score 15,811543

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