Biodegradable porous FeMn(-xAg) alloys

Bartkowska, Aleksandra|||0000-0002-6133-7155; Careta, Oriol|||0000-0003-1333-0300; Turner, Adam Benedict|||0000-0002-4485-6738; Blanquer, Andreu|||0000-0002-3551-1885; Ibáñez, Elena|||0000-0002-0275-6958; Trobos, Margarita|||0000-0002-9253-6771; Nogués, Carme|||0000-0002-6361-8559; Pellicer, Eva|||0000-0002-8901-0998; Sort, Jordi|||0000-0003-1213-3639

Biodegradable porous FeMn(-xAg) alloys

In this work, porous FeMn(-xAg) alloys are fabricated through powder metallurgy methods. The effects of porosity and Ag addition on the microstructure, biodegradability, magnetic and mechanical properties of the alloys are investigated. Studies on the cytocompatibility, inflammatory cytokine respons...

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Autores:	Bartkowska, Aleksandra\|\|\|0000-0002-6133-7155, Careta, Oriol\|\|\|0000-0003-1333-0300, Turner, Adam Benedict\|\|\|0000-0002-4485-6738, Blanquer, Andreu\|\|\|0000-0002-3551-1885, Ibáñez, Elena\|\|\|0000-0002-0275-6958, Trobos, Margarita\|\|\|0000-0002-9253-6771, Nogués, Carme\|\|\|0000-0002-6361-8559, Pellicer, Eva\|\|\|0000-0002-8901-0998, Sort, Jordi\|\|\|0000-0003-1213-3639
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:271802
Acceso en línea:	https://ddd.uab.cat/record/271802 https://dx.doi.org/urn:doi:10.1039/D2MA00867J
Access Level:	acceso abierto

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repository_id_str
spelling	Biodegradable porous FeMn(-xAg) alloysassessment of cytocompatibility, mechanical, magnetic and antibiofilm propertiesBartkowska, Aleksandra\|\|\|0000-0002-6133-7155Careta, Oriol\|\|\|0000-0003-1333-0300Turner, Adam Benedict\|\|\|0000-0002-4485-6738Blanquer, Andreu\|\|\|0000-0002-3551-1885Ibáñez, Elena\|\|\|0000-0002-0275-6958Trobos, Margarita\|\|\|0000-0002-9253-6771Nogués, Carme\|\|\|0000-0002-6361-8559Pellicer, Eva\|\|\|0000-0002-8901-0998Sort, Jordi\|\|\|0000-0003-1213-3639In this work, porous FeMn(-xAg) alloys are fabricated through powder metallurgy methods. The effects of porosity and Ag addition on the microstructure, biodegradability, magnetic and mechanical properties of the alloys are investigated. Studies on the cytocompatibility, inflammatory cytokine response and antibacterial effect are also conducted. The fabricated alloys exhibit a macro- and nanoporous structure, with uniformly distributed silver particles. The biodegradability tests reveal that the release of Mn to the Hank's solution is higher than that of Fe, without significant differences between the alloys. The degradation products consist mainly of Fe, Mn, O and compounds enriched in Ca, P and Cl. As-sintered alloys show a low saturation magnetization value (below 1 emu g-1), which does not increase significantly with immersion time. The results on biocompatibility indicate that all tested alloys are non-cytotoxic, but the addition of Ag might interfere with cell proliferation. However, the ions released by the FeMn(-xAg) alloys do not induce an inflammatory response in macrophages. The obtained results on microbiological interactions reveal that although no significant bactericidal effect is observed at 4 h between FeMn control and FeMn-5Ag, a significant reduction in the total biofilm biomass of both live and dead bacteria is observed after 24 h in Ag containing FeMn-5Ag surfaces. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271802https://dx.doi.org/urn:doi:10.1039/D2MA00867Jreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 861046Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116844RB-C21Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0292Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-503open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2718022026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Biodegradable porous FeMn(-xAg) alloys assessment of cytocompatibility, mechanical, magnetic and antibiofilm properties
title	Biodegradable porous FeMn(-xAg) alloys
spellingShingle	Biodegradable porous FeMn(-xAg) alloys Bartkowska, Aleksandra\|\|\|0000-0002-6133-7155
title_short	Biodegradable porous FeMn(-xAg) alloys
title_full	Biodegradable porous FeMn(-xAg) alloys
title_fullStr	Biodegradable porous FeMn(-xAg) alloys
title_full_unstemmed	Biodegradable porous FeMn(-xAg) alloys
title_sort	Biodegradable porous FeMn(-xAg) alloys
dc.creator.none.fl_str_mv	Bartkowska, Aleksandra\|\|\|0000-0002-6133-7155 Careta, Oriol\|\|\|0000-0003-1333-0300 Turner, Adam Benedict\|\|\|0000-0002-4485-6738 Blanquer, Andreu\|\|\|0000-0002-3551-1885 Ibáñez, Elena\|\|\|0000-0002-0275-6958 Trobos, Margarita\|\|\|0000-0002-9253-6771 Nogués, Carme\|\|\|0000-0002-6361-8559 Pellicer, Eva\|\|\|0000-0002-8901-0998 Sort, Jordi\|\|\|0000-0003-1213-3639
author	Bartkowska, Aleksandra\|\|\|0000-0002-6133-7155
author_facet	Bartkowska, Aleksandra\|\|\|0000-0002-6133-7155 Careta, Oriol\|\|\|0000-0003-1333-0300 Turner, Adam Benedict\|\|\|0000-0002-4485-6738 Blanquer, Andreu\|\|\|0000-0002-3551-1885 Ibáñez, Elena\|\|\|0000-0002-0275-6958 Trobos, Margarita\|\|\|0000-0002-9253-6771 Nogués, Carme\|\|\|0000-0002-6361-8559 Pellicer, Eva\|\|\|0000-0002-8901-0998 Sort, Jordi\|\|\|0000-0003-1213-3639
author_role	author
author2	Careta, Oriol\|\|\|0000-0003-1333-0300 Turner, Adam Benedict\|\|\|0000-0002-4485-6738 Blanquer, Andreu\|\|\|0000-0002-3551-1885 Ibáñez, Elena\|\|\|0000-0002-0275-6958 Trobos, Margarita\|\|\|0000-0002-9253-6771 Nogués, Carme\|\|\|0000-0002-6361-8559 Pellicer, Eva\|\|\|0000-0002-8901-0998 Sort, Jordi\|\|\|0000-0003-1213-3639
author2_role	author author author author author author author author
description	In this work, porous FeMn(-xAg) alloys are fabricated through powder metallurgy methods. The effects of porosity and Ag addition on the microstructure, biodegradability, magnetic and mechanical properties of the alloys are investigated. Studies on the cytocompatibility, inflammatory cytokine response and antibacterial effect are also conducted. The fabricated alloys exhibit a macro- and nanoporous structure, with uniformly distributed silver particles. The biodegradability tests reveal that the release of Mn to the Hank's solution is higher than that of Fe, without significant differences between the alloys. The degradation products consist mainly of Fe, Mn, O and compounds enriched in Ca, P and Cl. As-sintered alloys show a low saturation magnetization value (below 1 emu g-1), which does not increase significantly with immersion time. The results on biocompatibility indicate that all tested alloys are non-cytotoxic, but the addition of Ag might interfere with cell proliferation. However, the ions released by the FeMn(-xAg) alloys do not induce an inflammatory response in macrophages. The obtained results on microbiological interactions reveal that although no significant bactericidal effect is observed at 4 h between FeMn control and FeMn-5Ag, a significant reduction in the total biofilm biomass of both live and dead bacteria is observed after 24 h in Ag containing FeMn-5Ag surfaces.
publishDate	2023
dc.date.none.fl_str_mv	2 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/271802 https://dx.doi.org/urn:doi:10.1039/D2MA00867J
url	https://ddd.uab.cat/record/271802 https://dx.doi.org/urn:doi:10.1039/D2MA00867J
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission https://doi.org/10.13039/501100000780 861046 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116844RB-C21 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0292 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-503
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Biodegradable porous FeMn(-xAg) alloys

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