Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing

Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investi...

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Detalles Bibliográficos
Autor: Aguilar Lepe, Juan de los Reyes
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/41298
Acceso en línea:http://22111247
https://hdl.handle.net/10578/41298
Access Level:acceso abierto
Palabra clave:Astrocyte
Cortical network activity
Dynamic range
Sensory information processing
Sensory specific modalities
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spelling Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processingAguilar Lepe, Juan de los ReyesAstrocyteCortical network activityDynamic rangeSensory information processingSensory specific modalitiesCortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities.Elsevier202520252023info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://22111247https://hdl.handle.net/10578/41298reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/412982026-05-27T07:36:41Z
dc.title.none.fl_str_mv Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
title Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
spellingShingle Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
Aguilar Lepe, Juan de los Reyes
Astrocyte
Cortical network activity
Dynamic range
Sensory information processing
Sensory specific modalities
title_short Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
title_full Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
title_fullStr Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
title_full_unstemmed Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
title_sort Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing
dc.creator.none.fl_str_mv Aguilar Lepe, Juan de los Reyes
author Aguilar Lepe, Juan de los Reyes
author_facet Aguilar Lepe, Juan de los Reyes
author_role author
dc.subject.none.fl_str_mv Astrocyte
Cortical network activity
Dynamic range
Sensory information processing
Sensory specific modalities
topic Astrocyte
Cortical network activity
Dynamic range
Sensory information processing
Sensory specific modalities
description Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://22111247
https://hdl.handle.net/10578/41298
url http://22111247
https://hdl.handle.net/10578/41298
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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