The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control

Monkeypox; PCR; Quality control

Detalhes bibliográficos
Autores: de Salazar, Adolfo, Martínez, Miguel J., Navero Castillejos, Jessica, Negredo, Anabel, Galan, Juan Carlos, Rojo Molinero, Estrella, Antón Pagarolas, Andrés
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10809
Acesso em linha:https://hdl.handle.net/11351/10809
http://hdl.handle.net/11351/10809
Access Level:Acceso aberto
Palavra-chave:Control de qualitat
Verola del mico - Diagnòstic
ADN
ORGANISMS::Viruses::DNA Viruses::Poxviridae::Chordopoxvirinae::Orthopoxvirus::Monkeypox virus
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
PUBLIC HEALTH::Environmental Health::General Aspects::Control::Quality Control
ORGANISMOS::virus::virus ADN::Poxviridae::Chordopoxvirinae::Orthopoxvirus::virus de la viruela del mono
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADN
SALUD PÚBLICA::salud ambiental::aspectos generales::control::control de calidad
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oai_identifier_str oai:recercat.cat:11351/10809
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
title The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
spellingShingle The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
de Salazar, Adolfo
Control de qualitat
Verola del mico - Diagnòstic
ADN
ORGANISMS::Viruses::DNA Viruses::Poxviridae::Chordopoxvirinae::Orthopoxvirus::Monkeypox virus
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
PUBLIC HEALTH::Environmental Health::General Aspects::Control::Quality Control
ORGANISMOS::virus::virus ADN::Poxviridae::Chordopoxvirinae::Orthopoxvirus::virus de la viruela del mono
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADN
SALUD PÚBLICA::salud ambiental::aspectos generales::control::control de calidad
title_short The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
title_full The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
title_fullStr The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
title_full_unstemmed The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
title_sort The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control
dc.creator.none.fl_str_mv de Salazar, Adolfo
Martínez, Miguel J.
Navero Castillejos, Jessica
Negredo, Anabel
Galan, Juan Carlos
Rojo Molinero, Estrella
Antón Pagarolas, Andrés
author de Salazar, Adolfo
author_facet de Salazar, Adolfo
Martínez, Miguel J.
Navero Castillejos, Jessica
Negredo, Anabel
Galan, Juan Carlos
Rojo Molinero, Estrella
Antón Pagarolas, Andrés
author_role author
author2 Martínez, Miguel J.
Navero Castillejos, Jessica
Negredo, Anabel
Galan, Juan Carlos
Rojo Molinero, Estrella
Antón Pagarolas, Andrés
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[de Salazar A] Servicio de Microbiología, Hospital Universitario San Cecilio, Granada, Spain. Instituto de Investigación Biosanitaria Ibs.Granada, Granada, Spain. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. [Martínez MJ] Servicio de Microbiología, Hospital Clinic de Barcelona, Spain. Instituto de Salud Global de Barcelona (ISGloba), Barcelona, Spain. [Navero‐Castillejos J] Servicio de Microbiología, Hospital Clinic de Barcelona, Spain. [Negredo A] Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. [Galán JC] Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Rojo Molinero E] Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. Departamento de Microbiología, Hospital Universitario Son Espases, Health Research Institute of Balearic Islands (IdISBa), Palma, Spain. [Antón Pagarolas A] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Control de qualitat
Verola del mico - Diagnòstic
ADN
ORGANISMS::Viruses::DNA Viruses::Poxviridae::Chordopoxvirinae::Orthopoxvirus::Monkeypox virus
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
PUBLIC HEALTH::Environmental Health::General Aspects::Control::Quality Control
ORGANISMOS::virus::virus ADN::Poxviridae::Chordopoxvirinae::Orthopoxvirus::virus de la viruela del mono
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADN
SALUD PÚBLICA::salud ambiental::aspectos generales::control::control de calidad
topic Control de qualitat
Verola del mico - Diagnòstic
ADN
ORGANISMS::Viruses::DNA Viruses::Poxviridae::Chordopoxvirinae::Orthopoxvirus::Monkeypox virus
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
PUBLIC HEALTH::Environmental Health::General Aspects::Control::Quality Control
ORGANISMOS::virus::virus ADN::Poxviridae::Chordopoxvirinae::Orthopoxvirus::virus de la viruela del mono
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADN
SALUD PÚBLICA::salud ambiental::aspectos generales::control::control de calidad
description Monkeypox; PCR; Quality control
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10809
http://hdl.handle.net/11351/10809
url https://hdl.handle.net/11351/10809
http://hdl.handle.net/11351/10809
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Medical Virology;95(11)
https://doi.org/10.1002/jmv.29240
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419625770385408
spelling The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality controlde Salazar, AdolfoMartínez, Miguel J.Navero Castillejos, JessicaNegredo, AnabelGalan, Juan CarlosRojo Molinero, EstrellaAntón Pagarolas, AndrésControl de qualitatVerola del mico - DiagnòsticADNORGANISMS::Viruses::DNA Viruses::Poxviridae::Chordopoxvirinae::Orthopoxvirus::Monkeypox virusCHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNAPUBLIC HEALTH::Environmental Health::General Aspects::Control::Quality ControlORGANISMOS::virus::virus ADN::Poxviridae::Chordopoxvirinae::Orthopoxvirus::virus de la viruela del monoCOMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADNSALUD PÚBLICA::salud ambiental::aspectos generales::control::control de calidadMonkeypox; PCR; Quality controlVerola del mico; PCR; Control de qualitatViruela del mono; PCR; Control de calidadTo evaluate molecular assays for Mpox diagnosis available in various clinical microbiology services in Spain through a quality control (QC) approach. A total of 14 centers from across Spain participated in the study. The Reference Laboratory dispatched eight serum samples and eight nucleic acid extracts to each participating center. Some samples were spiked with Mpox or Vaccinia virus to mimic positive samples for Mpox or other orthopox viruses. Participating centers provided information on the results obtained, as well as the laboratory methods used. Among the 14 participating centers seven different commercial assays were employed, with the most commonly used kit being LightMix Modular Orthopox/Monkeypox (Mpox) Virus (Roche®). Of the 12 centers conducting Mpox determinations, concordance ranged from 62.5% (n = 1) to 100% (n = 11) for eluates and from 75.0% (n = 1) to 100% (n = 10) for serum. Among the 10 centers performing Orthopoxvirus determinations, a 100% concordance was observed for eluates, while for serum, concordance ranged from 87.5% (n = 6) to 100% (n = 4). Repeatedly, 6 different centers reported a false negative in serum samples for Orthopoxvirus diagnosis, particularly in a sample with borderline Ct = 39. Conversely, one center, using the TaqMan™ Mpox Virus Microbe Detection Assay (Thermo Fisher), reported false positives in Mpox diagnosis for samples spiked with vaccinia virus due to cross-reactions. We observed a positive correlation of various diagnostic assays for Mpox used by the participating centers with the reference values. Our results highlight the significance of standardization, validation, and ongoing QC in the microbiological diagnosis of infectious diseases, which might be particularly relevant for emerging viruses.This research was supported by CIBER (Strategic Action for Monkeypox)—Consorcio Centro de Investigación Biomédica en Red—(CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU. A. d. S. is supported by ‘Instituto de Salud Carlos III’ (grant number JR22/00055).WileyInstitut Català de la Salut[de Salazar A] Servicio de Microbiología, Hospital Universitario San Cecilio, Granada, Spain. Instituto de Investigación Biosanitaria Ibs.Granada, Granada, Spain. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. [Martínez MJ] Servicio de Microbiología, Hospital Clinic de Barcelona, Spain. Instituto de Salud Global de Barcelona (ISGloba), Barcelona, Spain. [Navero‐Castillejos J] Servicio de Microbiología, Hospital Clinic de Barcelona, Spain. [Negredo A] Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. [Galán JC] Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Rojo Molinero E] Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. Departamento de Microbiología, Hospital Universitario Son Espases, Health Research Institute of Balearic Islands (IdISBa), Palma, Spain. [Antón Pagarolas A] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10809http://hdl.handle.net/11351/10809Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Medical Virology;95(11)https://doi.org/10.1002/jmv.29240Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/108092026-05-29T05:05:01Z
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