Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

[Background and Purpose] The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small-molecule diethylamine-azobenzene-quaternary ammonium (DENAQ) was used to photomodulate activity of c...

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Detalhes bibliográficos
Autores: Ares-Suárez, David, Íñigo-Portugués, Almudena, Velasco, Enrique, Quirce, Susana, Aleixandre-Carrera, Fernando, Díaz-Tahoces, Ariadna, Acosta, M. Carmen, Lin, Wan-Chen, Kramer, Richard H., Belmonte, Carlos, Gallar, Juana, Meseguer, Víctor M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420024
Acesso em linha:http://hdl.handle.net/10261/420024
https://api.elsevier.com/content/abstract/scopus_id/105017963326
Access Level:acceso abierto
Palavra-chave:DENAQ
P2X channels
Chemical photoswitches
Cornea cold nerve endings
Dry eye
Ocular discomfort
Voltage‐gated potassium channels
Descrição
Resumo:[Background and Purpose] The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small-molecule diethylamine-azobenzene-quaternary ammonium (DENAQ) was used to photomodulate activity of cold-sensing nerve terminals in control and chronic tear-deficient corneas. Furthermore, DENAQ was used for in vivo photochemical regulation of the thermally induced blink reflex.

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