Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study

Gutiérrez Bedmar, Mario; Gil, Fernando; Olmedo, Pablo; Ruiz Canela, Miguel; Martínez-González, Miguel Ángel, 1957-; Salas Salvadó, Jordi; Babio, Nancy; Fitó Colomer, Montserrat; Del Val García, Jose Luís; Corella Piquer, Dolores; Sorlí, José V.; Ros Rahola, Emilio; Fiol Sala, Miguel; Estruch Riba, Ramon; Santos Lozano, José Manuel; Arós, Fernando; Serra Majem, Lluís; Pintó Sala, Xavier; Gómez Gracia, Enrique; Muñoz Bravo, Carlos

Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study

Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SS...

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Autores:	Gutiérrez Bedmar, Mario, Gil, Fernando, Olmedo, Pablo, Ruiz Canela, Miguel, Martínez-González, Miguel Ángel, 1957-, Salas Salvadó, Jordi, Babio, Nancy, Fitó Colomer, Montserrat, Del Val García, Jose Luís, Corella Piquer, Dolores, Sorlí, José V., Ros Rahola, Emilio, Fiol Sala, Miguel, Estruch Riba, Ramon, Santos Lozano, José Manuel, Arós, Fernando, Serra Majem, Lluís, Pintó Sala, Xavier, Gómez Gracia, Enrique, Muñoz Bravo, Carlos
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Recursos:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/191805
Acesso em linha:	https://hdl.handle.net/2445/191805
Access Level:	acceso abierto
Palavra-chave:	Malalties cardiovasculars Seleni Cardiovascular diseases Selenium

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spelling	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control StudyGutiérrez Bedmar, MarioGil, FernandoOlmedo, PabloRuiz Canela, MiguelMartínez-González, Miguel Ángel, 1957-Salas Salvadó, JordiBabio, NancyFitó Colomer, MontserratDel Val García, Jose LuísCorella Piquer, DoloresSorlí, José V.Ros Rahola, EmilioFiol Sala, MiguelEstruch Riba, RamonSantos Lozano, José ManuelArós, FernandoSerra Majem, LluísPintó Sala, XavierGómez Gracia, EnriqueMuñoz Bravo, CarlosMalalties cardiovascularsSeleniCardiovascular diseasesSeleniumBackground: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the PREvencion con DIeta MEDiterranea (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003-2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 mu g/L vs. 103.8 mu g/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose-response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27-0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence.MDPI2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/191805Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm11226664Journal of Clinical Medicine, 2022, vol. 11, issue. 22, p. 6664https://doi.org/10.3390/jcm11226664cc by (c) Gutiérrez Bedmar, Mario et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1918052026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
spellingShingle	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study Gutiérrez Bedmar, Mario Malalties cardiovasculars Seleni Cardiovascular diseases Selenium
title_short	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_full	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_fullStr	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_full_unstemmed	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_sort	Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
dc.creator.none.fl_str_mv	Gutiérrez Bedmar, Mario Gil, Fernando Olmedo, Pablo Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Salas Salvadó, Jordi Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Muñoz Bravo, Carlos
author	Gutiérrez Bedmar, Mario
author_facet	Gutiérrez Bedmar, Mario Gil, Fernando Olmedo, Pablo Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Salas Salvadó, Jordi Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Muñoz Bravo, Carlos
author_role	author
author2	Gil, Fernando Olmedo, Pablo Ruiz Canela, Miguel Martínez-González, Miguel Ángel, 1957- Salas Salvadó, Jordi Babio, Nancy Fitó Colomer, Montserrat Del Val García, Jose Luís Corella Piquer, Dolores Sorlí, José V. Ros Rahola, Emilio Fiol Sala, Miguel Estruch Riba, Ramon Santos Lozano, José Manuel Arós, Fernando Serra Majem, Lluís Pintó Sala, Xavier Gómez Gracia, Enrique Muñoz Bravo, Carlos
author2_role	author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Malalties cardiovasculars Seleni Cardiovascular diseases Selenium
topic	Malalties cardiovasculars Seleni Cardiovascular diseases Selenium
description	Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the PREvencion con DIeta MEDiterranea (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003-2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 mu g/L vs. 103.8 mu g/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose-response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27-0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/191805
url	https://hdl.handle.net/2445/191805
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/jcm11226664 Journal of Clinical Medicine, 2022, vol. 11, issue. 22, p. 6664 https://doi.org/10.3390/jcm11226664
dc.rights.none.fl_str_mv	cc by (c) Gutiérrez Bedmar, Mario et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Gutiérrez Bedmar, Mario et al., 2022 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	13 p. application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study

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