Mathematical models and multiscale simulations of cellular secretion processes

Exocytosis is the cellular process whereby a product such as a hormone or a neurotransmitter is released as a response to stimulation. There are a lot of exocytotic cells in mammals, and each cell type has their specific subcellular mechanisms, needed to achieve the final substance release. Therefor...

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Detalles Bibliográficos
Autor: González-Vélez, Virginia
Tipo de recurso: tesis doctoral
Fecha de publicación:2011
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/94768
Acceso en línea:https://hdl.handle.net/2117/94768
https://dx.doi.org/10.5821/dissertation-2117-94768
Access Level:acceso abierto
Palabra clave:Modelització en etapes múltiples
Cèl·lules animals -- Secrecions -- Models matemàtics
Àrees temàtiques de la UPC::Informàtica
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oai_identifier_str oai:upcommons.upc.edu:2117/94768
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Mathematical models and multiscale simulations of cellular secretion processes
title Mathematical models and multiscale simulations of cellular secretion processes
spellingShingle Mathematical models and multiscale simulations of cellular secretion processes
González-Vélez, Virginia
Modelització en etapes múltiples
Cèl·lules animals -- Secrecions -- Models matemàtics
Àrees temàtiques de la UPC::Informàtica
title_short Mathematical models and multiscale simulations of cellular secretion processes
title_full Mathematical models and multiscale simulations of cellular secretion processes
title_fullStr Mathematical models and multiscale simulations of cellular secretion processes
title_full_unstemmed Mathematical models and multiscale simulations of cellular secretion processes
title_sort Mathematical models and multiscale simulations of cellular secretion processes
dc.creator.none.fl_str_mv González-Vélez, Virginia
author González-Vélez, Virginia
author_facet González-Vélez, Virginia
author_role author
dc.contributor.none.fl_str_mv Gil Gómez, Amparo
dc.subject.none.fl_str_mv Modelització en etapes múltiples
Cèl·lules animals -- Secrecions -- Models matemàtics
Àrees temàtiques de la UPC::Informàtica
topic Modelització en etapes múltiples
Cèl·lules animals -- Secrecions -- Models matemàtics
Àrees temàtiques de la UPC::Informàtica
description Exocytosis is the cellular process whereby a product such as a hormone or a neurotransmitter is released as a response to stimulation. There are a lot of exocytotic cells in mammals, and each cell type has their specific subcellular mechanisms, needed to achieve the final substance release. Therefore, unveiling the role of subcellular mechanisms in secretion processes is highly relevant to understand disease evolution and possible therapies. The efficiency of the coupling between stimulus and secretion is mainly managed by an intracellular Ca2+ signal. In the present thesis, a modeling approach of Ca2+-triggered secretion is presented for some different cellular types. In particular, cells with different characteristic time scales were chosen in order to discuss about a multiscale approach for studying spatiotemporal features of secretion processes. The object of this piece of research ranges from a short temporal scale (fast secretion) up to a long temporal scale (slow secretion). The study also discuss the intermediate temporal scale, and the joining point between theoretical methodologies. Cellular Ca2+ and secretion dynamics have been studied in the abovementioned timescales for the calyx of Held presynaptic terminal, the pancreatic alpha cell, and the adrenal chromaffin cell, respectively. The aim of this work has been twofold: first, to develop mathematical models that follow actual sub-cellular mechanisms involved in secretion, and second, to make simulations on these models in order to reproduce the experimentally observed Ca2+ and secretory behaviour. The ultimate goal is to propose common methodologies and algorithms to support the theoretical approach for studying multiscale cellular processes.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-07-26
2013
2013-04-08
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/94768
https://dx.doi.org/10.5821/dissertation-2117-94768
url https://hdl.handle.net/2117/94768
https://dx.doi.org/10.5821/dissertation-2117-94768
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat Politècnica de Catalunya
publisher.none.fl_str_mv Universitat Politècnica de Catalunya
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Mathematical models and multiscale simulations of cellular secretion processesGonzález-Vélez, VirginiaModelització en etapes múltiplesCèl·lules animals -- Secrecions -- Models matemàticsÀrees temàtiques de la UPC::InformàticaExocytosis is the cellular process whereby a product such as a hormone or a neurotransmitter is released as a response to stimulation. There are a lot of exocytotic cells in mammals, and each cell type has their specific subcellular mechanisms, needed to achieve the final substance release. Therefore, unveiling the role of subcellular mechanisms in secretion processes is highly relevant to understand disease evolution and possible therapies. The efficiency of the coupling between stimulus and secretion is mainly managed by an intracellular Ca2+ signal. In the present thesis, a modeling approach of Ca2+-triggered secretion is presented for some different cellular types. In particular, cells with different characteristic time scales were chosen in order to discuss about a multiscale approach for studying spatiotemporal features of secretion processes. The object of this piece of research ranges from a short temporal scale (fast secretion) up to a long temporal scale (slow secretion). The study also discuss the intermediate temporal scale, and the joining point between theoretical methodologies. Cellular Ca2+ and secretion dynamics have been studied in the abovementioned timescales for the calyx of Held presynaptic terminal, the pancreatic alpha cell, and the adrenal chromaffin cell, respectively. The aim of this work has been twofold: first, to develop mathematical models that follow actual sub-cellular mechanisms involved in secretion, and second, to make simulations on these models in order to reproduce the experimentally observed Ca2+ and secretory behaviour. The ultimate goal is to propose common methodologies and algorithms to support the theoretical approach for studying multiscale cellular processes.Exocitosis es el proceso celular por el cual un producto, sea una hormona o un neurotransmisor, es liberado en respuesta a un estímulo. Existen muchas células exocitóticas en los mamíferos y cada una de ellas posee sus mecanismos específicos para llevar a cabo esta función. Por esta razón, es de gran relevancia descubrir cuáles son los mecanismos intracelulares involucrados en el proceso de secreción para comprender la evolución y posibles terapias asociadas a las enfermedades. La eficiencia del acople entre el estímulo y la secreción celular es controlada por una señal de Ca2+ intracelular. En esta tesis se presenta una investigación teórica de modelado sobre la secreción controlada por Ca2+ para diferentes tipos celulares. En particular, se han escogido células con diferentes tiempos característicos para darle un enfoque multiescala al estudio. Cada tipo celular presenta características espacio-temporales específicas involucradas en la secreción. El estudio cubre desde una escala temporal corta (secreción rápida) hasta una escala temporal larga (secreción lenta), discutiendo también la escala intermedia que provee el punto de convergencia entre las metodologías empleadas. Para estudiar estas escalas temporales, se han escogido la terminal presináptica del cáliz de Held, la célula alfa de páncreas y la célula cromafin de glándulas suprarrenales, respectivamente. Los principales objetivos del trabajo han sido: Primero, proponer modelos matemáticos de los mecanismos intracelulares reales que participan en la secreción para cada tipo celular, y segundo, desarrollar simulaciones que logren reproducir el comportamiento fisiológico del Ca2+ y la secreción celulares. La perspectiva se orienta a proponer metodologías y algoritmos multiescala que puedan ser comunes para el estudio teórico de los procesos celulares.Universitat Politècnica de CatalunyaGil Gómez, Amparo20112011-07-2620132013-04-08doctoral thesishttp://purl.org/coar/resource_type/c_db06VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/2117/94768https://dx.doi.org/10.5821/dissertation-2117-94768reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/947682026-05-27T15:37:01Z
score 15.301603

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