Stability in community-acquired pneumonia: one step forward with markers?

Background: Biological markers as an expression of systemic inflammation have been recognised as useful for evaluating the host response in community-acquired pneumonia (CAP). The objective of this study was to evaluate whether the biological markers procalcitonin (PCT) and C-reactive protein (CRP)...

Descripción completa

Detalles Bibliográficos
Autores: Menéndez, Rosario, Martinez, R., Reyes, Soledad, Mensa, J., Polverino, Eva, Filella, X., Esquinas López, Cristina, Martinez, A., Ramirez, P., Torres Martí, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/189956
Acceso en línea:https://hdl.handle.net/2445/189956
Access Level:acceso abierto
Palabra clave:Pneumònia adquirida a la comunitat
Marcadors bioquímics
Mètode longitudinal
Community-acquired pneumonia
Biochemical markers
Longitudinal method
id ES_cbbf6267e89482bf792ef5d33471f455
oai_identifier_str oai:recercat.cat:2445/189956
network_acronym_str ES
network_name_str España
repository_id_str
spelling Stability in community-acquired pneumonia: one step forward with markers?Menéndez, RosarioMartinez, R.Reyes, SoledadMensa, J.Polverino, EvaFilella, X.Esquinas López, CristinaMartinez, A.Ramirez, P.Torres Martí, AntoniPneumònia adquirida a la comunitatMarcadors bioquímicsMètode longitudinalCommunity-acquired pneumoniaBiochemical markersLongitudinal methodBackground: Biological markers as an expression of systemic inflammation have been recognised as useful for evaluating the host response in community-acquired pneumonia (CAP). The objective of this study was to evaluate whether the biological markers procalcitonin (PCT) and C-reactive protein (CRP) might reflect stability after 72 h of treatment and the absence of subsequent severe complications. Methods: A prospective cohort study was performed in 394 hospitalised patients with CAP. Clinical stability was evaluated using modified Halm's criteria: temperature (37.2uC; heart rate (100 beats/min; respiratory rate (24 breaths/min; systolic blood pressure >90 mm Hg; oxygen saturation >90%; or arterial oxygen tension >60 mm Hg. PCT and CRP levels were measured on day 1 and after 72 h. Severe complications were defined as mechanical ventilation, shock and/or intensive care unit (ICU) admission, or death after 72 h of treatment. Results: 220 patients achieved clinical stability at 72 h and had significantly lower levels of CRP (4.2 vs 7 mg/dl) and of PCT (0.33 vs 0.48 ng/ml). Regression logistic analyses were performed to calculate several areas under the ROC curve (AUC) to predict severe complications. The AUC for clinical stability was 0.77, 0.84 when CRP was added (p=0.059) and 0.77 when PCT was added (p=0.45). When clinical stability was achieved within 72 h and marker levels were below the cut-off points (0.25 ng/ml for PCT and 3 mg/dl for CRP), no severe complications occurred. Conclusions: Low levels of CRP and PCT at 72 h in addition to clinical criteria might improve the prediction of absence of severe complications.BMJ Publishing Group2022202220092022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/189956Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1136/thx.2009.118612Thorax, 2009, vol. 64, num. 11, p. 987-992https://doi.org/10.1136/thx.2009.118612(c) BMJ Publishing Group, 2009info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1899562026-05-29T05:05:01Z
dc.title.none.fl_str_mv Stability in community-acquired pneumonia: one step forward with markers?
title Stability in community-acquired pneumonia: one step forward with markers?
spellingShingle Stability in community-acquired pneumonia: one step forward with markers?
Menéndez, Rosario
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Mètode longitudinal
Community-acquired pneumonia
Biochemical markers
Longitudinal method
title_short Stability in community-acquired pneumonia: one step forward with markers?
title_full Stability in community-acquired pneumonia: one step forward with markers?
title_fullStr Stability in community-acquired pneumonia: one step forward with markers?
title_full_unstemmed Stability in community-acquired pneumonia: one step forward with markers?
title_sort Stability in community-acquired pneumonia: one step forward with markers?
dc.creator.none.fl_str_mv Menéndez, Rosario
Martinez, R.
Reyes, Soledad
Mensa, J.
Polverino, Eva
Filella, X.
Esquinas López, Cristina
Martinez, A.
Ramirez, P.
Torres Martí, Antoni
author Menéndez, Rosario
author_facet Menéndez, Rosario
Martinez, R.
Reyes, Soledad
Mensa, J.
Polverino, Eva
Filella, X.
Esquinas López, Cristina
Martinez, A.
Ramirez, P.
Torres Martí, Antoni
author_role author
author2 Martinez, R.
Reyes, Soledad
Mensa, J.
Polverino, Eva
Filella, X.
Esquinas López, Cristina
Martinez, A.
Ramirez, P.
Torres Martí, Antoni
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia adquirida a la comunitat
Marcadors bioquímics
Mètode longitudinal
Community-acquired pneumonia
Biochemical markers
Longitudinal method
topic Pneumònia adquirida a la comunitat
Marcadors bioquímics
Mètode longitudinal
Community-acquired pneumonia
Biochemical markers
Longitudinal method
description Background: Biological markers as an expression of systemic inflammation have been recognised as useful for evaluating the host response in community-acquired pneumonia (CAP). The objective of this study was to evaluate whether the biological markers procalcitonin (PCT) and C-reactive protein (CRP) might reflect stability after 72 h of treatment and the absence of subsequent severe complications. Methods: A prospective cohort study was performed in 394 hospitalised patients with CAP. Clinical stability was evaluated using modified Halm's criteria: temperature (37.2uC; heart rate (100 beats/min; respiratory rate (24 breaths/min; systolic blood pressure >90 mm Hg; oxygen saturation >90%; or arterial oxygen tension >60 mm Hg. PCT and CRP levels were measured on day 1 and after 72 h. Severe complications were defined as mechanical ventilation, shock and/or intensive care unit (ICU) admission, or death after 72 h of treatment. Results: 220 patients achieved clinical stability at 72 h and had significantly lower levels of CRP (4.2 vs 7 mg/dl) and of PCT (0.33 vs 0.48 ng/ml). Regression logistic analyses were performed to calculate several areas under the ROC curve (AUC) to predict severe complications. The AUC for clinical stability was 0.77, 0.84 when CRP was added (p=0.059) and 0.77 when PCT was added (p=0.45). When clinical stability was achieved within 72 h and marker levels were below the cut-off points (0.25 ng/ml for PCT and 3 mg/dl for CRP), no severe complications occurred. Conclusions: Low levels of CRP and PCT at 72 h in addition to clinical criteria might improve the prediction of absence of severe complications.
publishDate 2009
dc.date.none.fl_str_mv 2009
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189956
url https://hdl.handle.net/2445/189956
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1136/thx.2009.118612
Thorax, 2009, vol. 64, num. 11, p. 987-992
https://doi.org/10.1136/thx.2009.118612
dc.rights.none.fl_str_mv (c) BMJ Publishing Group, 2009
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group, 2009
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419615196545024
score 15.812429

Similares en LA Referencia