Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance

8 páginas, 5 figuras.-- et al.

Detalles Bibliográficos
Autores: Vendrell, Joan, El Bekay, Rajaa, Peral, Belén, García-Fuentes, Eduardo, Macías-González, Manuel, Fernández-Real, José M., Escoté, Xavier, Simó, Rafael, Tinahones, Francisco J.
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/40620
Acceso en línea:http://hdl.handle.net/10261/40620
Access Level:acceso abierto
Palabra clave:Glucagon-like peptide 1
Glp-1
Type 2 diabetes mellytus
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spelling Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistanceVendrell, JoanEl Bekay, RajaaPeral, BelénGarcía-Fuentes, EduardoMacías-González, ManuelFernández-Real, José M.Escoté, XavierSimó, RafaelTinahones, Francisco J.Glucagon-like peptide 1Glp-1Type 2 diabetes mellytus8 páginas, 5 figuras.-- et al.The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Furthermore, no relationship has been established between GLP-1 receptor (GLP-1R) in AT and obesity and insulin resistance (IR). We provide evidence for the presence of this receptor in AT and show that its mRNA and protein expressions are increased in visceral adipose depots from morbidly obese patients with a high degree of IR. Experiments with the 3T3-L1 cell line showed the lipolytic and lipogenic dose-dependent effect of GLP-1. Moreover, GLP-1 stimulated lipolysis in 3T3-L1 adipocytes in a receptor-dependent manner involving downstream adenylate cyclase/cAMP signaling. Our data also demonstrate that the expression of the GLP-1R in AT correlated positively with the homeostasis model assessment index in obese IR subjects. Furthermore, prospective studies carried out with patients that underwent biliopancreatic diversion surgery showed that subjects with high levels of GLP-1R expression in AT, which indicates a deficit of GLP-1 in this tissue, were those whose insulin sensitivity improved after surgery, suggesting the potential relationship between AT GLP-1R and insulin sensitivity amelioration in obese subjects. Altogether these results indicate that the GLP-1/GLP-1R system in AT represents another potential candidate for improving insulin sensitivity in obese patients.This work was supported by an unrestricted grant from Merck & Co., Inc., and also in part by Grants SAS PI-0251 and 0255/2007 from the Andalusian Health Service; the Spanish Ministry of Health Grants PS09/00997 and PI070953; the Consejería de Innovación Grants CTS04369 and CTS-03039; and MICINN/FEDER (Ministerio de Ciencia e Innovación, subprograma proyectos de infraestricutura cientifico-tecnológico cofinanciadas con el Fondo Europeo de Desarrollo Regional) Grants BFU2007-60180 and SAF-2009-10461). R.E.B., E.G.-F., and D.M.S. are recipients of a “Miguel Servet” (FIS-2007) postdoctoral Grant CP07/00288, CP04/00133, CP04/00039, PS09/01060, and CP08/00058 from the Spanish Ministry of Health. M.M.-G. is supported by the Research Stabilization Program of the Instituto de Salud Carlos III Grant CES 10/004. X.E. is supported by a fellowship from the JdlC Program and Grant JDCI20071020. This work was also supported by Instituto de Salud Carlos III Grants CD07/00208 and CD10/00285, Formación y Perfeccionamiento del Personal Investigador, Fondo de Investigación Sanitaria, Spain (to Y.J.-G. and G.P.).Peer reviewedEndocrine Society201120112012info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/40620reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.dx.org/10.1210/en.2011-1070info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/406202026-05-22T06:33:51Z
dc.title.none.fl_str_mv Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
title Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
spellingShingle Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
Vendrell, Joan
Glucagon-like peptide 1
Glp-1
Type 2 diabetes mellytus
title_short Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
title_full Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
title_fullStr Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
title_full_unstemmed Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
title_sort Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
dc.creator.none.fl_str_mv Vendrell, Joan
El Bekay, Rajaa
Peral, Belén
García-Fuentes, Eduardo
Macías-González, Manuel
Fernández-Real, José M.
Escoté, Xavier
Simó, Rafael
Tinahones, Francisco J.
author Vendrell, Joan
author_facet Vendrell, Joan
El Bekay, Rajaa
Peral, Belén
García-Fuentes, Eduardo
Macías-González, Manuel
Fernández-Real, José M.
Escoté, Xavier
Simó, Rafael
Tinahones, Francisco J.
author_role author
author2 El Bekay, Rajaa
Peral, Belén
García-Fuentes, Eduardo
Macías-González, Manuel
Fernández-Real, José M.
Escoté, Xavier
Simó, Rafael
Tinahones, Francisco J.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Glucagon-like peptide 1
Glp-1
Type 2 diabetes mellytus
topic Glucagon-like peptide 1
Glp-1
Type 2 diabetes mellytus
description 8 páginas, 5 figuras.-- et al.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/40620
url http://hdl.handle.net/10261/40620
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.dx.org/10.1210/en.2011-1070
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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