Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis

Background: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been asso...

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Autores: Costas Carrera, Ana, Verdolini, Norma, García Rizo, Clemente, Mezquida Mateos, Gisela, Janssen, Joost, Valli, Isabel, Corripio, Iluminada, Sánchez-Torres, Ana M, Bioque Alcázar, Miquel, Lobo, Antonio, González-Pinto, Ana, Rapado Castro, Marta, Vieta i Pascual, Eduard, 1963-, Serna Gómez, Elena de la, Mané Santacana, Anna, Roldán, Alexandra, Crossley, Nicolas, Penadés Rubio, Rafael, Cuesta, Manuel J., Parellada, Mara, Bernardo Arroyo, Miquel, PEPs group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219604
Acceso en línea:https://hdl.handle.net/2445/219604
Access Level:acceso abierto
Palabra clave:Psicosi
Complicacions en el part
Esquizofrènia
Ventricles cardíacs
Trastorns de la cognició
Psychoses
Labor complications (Obstetrics)
Schizophrenia
Ventricle of heart
Cognition disorders
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spelling Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosisCostas Carrera, AnaVerdolini, NormaGarcía Rizo, ClementeMezquida Mateos, GiselaJanssen, JoostValli, IsabelCorripio, IluminadaSánchez-Torres, Ana MBioque Alcázar, MiquelLobo, AntonioGonzález-Pinto, AnaRapado Castro, MartaVieta i Pascual, Eduard, 1963-Serna Gómez, Elena de laMané Santacana, AnnaRoldán, AlexandraCrossley, NicolasPenadés Rubio, RafaelCuesta, Manuel J.Parellada, MaraBernardo Arroyo, MiquelPEPs groupPsicosiComplicacions en el partEsquizofrèniaVentricles cardíacsTrastorns de la cognicióPsychosesLabor complications (Obstetrics)SchizophreniaVentricle of heartCognition disordersBackground: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods: We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results: FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions: Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.Cambridge University Press (CUP)2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/219604Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1017/S0033291723003185Psychological Medicine, 2023https://doi.org/10.1017/S0033291723003185cc-by (c) Costas Carrera, Ana et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2196042026-05-29T05:05:01Z
dc.title.none.fl_str_mv Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
title Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
spellingShingle Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
Costas Carrera, Ana
Psicosi
Complicacions en el part
Esquizofrènia
Ventricles cardíacs
Trastorns de la cognició
Psychoses
Labor complications (Obstetrics)
Schizophrenia
Ventricle of heart
Cognition disorders
title_short Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
title_full Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
title_fullStr Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
title_full_unstemmed Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
title_sort Difficulties during delivery brain ventricle enlargement and cognitive impairment in first episode psychosis
dc.creator.none.fl_str_mv Costas Carrera, Ana
Verdolini, Norma
García Rizo, Clemente
Mezquida Mateos, Gisela
Janssen, Joost
Valli, Isabel
Corripio, Iluminada
Sánchez-Torres, Ana M
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Rapado Castro, Marta
Vieta i Pascual, Eduard, 1963-
Serna Gómez, Elena de la
Mané Santacana, Anna
Roldán, Alexandra
Crossley, Nicolas
Penadés Rubio, Rafael
Cuesta, Manuel J.
Parellada, Mara
Bernardo Arroyo, Miquel
PEPs group
author Costas Carrera, Ana
author_facet Costas Carrera, Ana
Verdolini, Norma
García Rizo, Clemente
Mezquida Mateos, Gisela
Janssen, Joost
Valli, Isabel
Corripio, Iluminada
Sánchez-Torres, Ana M
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Rapado Castro, Marta
Vieta i Pascual, Eduard, 1963-
Serna Gómez, Elena de la
Mané Santacana, Anna
Roldán, Alexandra
Crossley, Nicolas
Penadés Rubio, Rafael
Cuesta, Manuel J.
Parellada, Mara
Bernardo Arroyo, Miquel
PEPs group
author_role author
author2 Verdolini, Norma
García Rizo, Clemente
Mezquida Mateos, Gisela
Janssen, Joost
Valli, Isabel
Corripio, Iluminada
Sánchez-Torres, Ana M
Bioque Alcázar, Miquel
Lobo, Antonio
González-Pinto, Ana
Rapado Castro, Marta
Vieta i Pascual, Eduard, 1963-
Serna Gómez, Elena de la
Mané Santacana, Anna
Roldán, Alexandra
Crossley, Nicolas
Penadés Rubio, Rafael
Cuesta, Manuel J.
Parellada, Mara
Bernardo Arroyo, Miquel
PEPs group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi
Complicacions en el part
Esquizofrènia
Ventricles cardíacs
Trastorns de la cognició
Psychoses
Labor complications (Obstetrics)
Schizophrenia
Ventricle of heart
Cognition disorders
topic Psicosi
Complicacions en el part
Esquizofrènia
Ventricles cardíacs
Trastorns de la cognició
Psychoses
Labor complications (Obstetrics)
Schizophrenia
Ventricle of heart
Cognition disorders
description Background: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods: We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results: FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions: Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219604
url https://hdl.handle.net/2445/219604
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/S0033291723003185
Psychological Medicine, 2023
https://doi.org/10.1017/S0033291723003185
dc.rights.none.fl_str_mv cc-by (c) Costas Carrera, Ana et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Costas Carrera, Ana et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press (CUP)
publisher.none.fl_str_mv Cambridge University Press (CUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419604459126784
score 15,812429

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