Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

El pdf del artículo es el manuscrito de autor.

Detalles Bibliográficos
Autores: Marín, Concepció, Aguilar, Esther, Mengod Los Arcos, Guadalupe, Cortés, Roser, Rodríguez-Oroz, M. Cruz, Obeso, José Ángel
Tipo de recurso: artículo
Fecha de publicación:2008
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/37163
Acceso en línea:http://hdl.handle.net/10261/37163
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Levodopa
Entacapone
6-Hydroxydopamine
Preproenkephalin
Preprodynorphin
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spelling Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changesMarín, ConcepcióAguilar, EstherMengod Los Arcos, GuadalupeCortés, RoserRodríguez-Oroz, M. CruzObeso, José ÁngelParkinson's diseaseLevodopaEntacapone6-HydroxydopaminePreproenkephalinPreprodynorphinEl pdf del artículo es el manuscrito de autor.Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR) to levodopa, levodopa-induced postsynaptic pharmacodynamic mechanisms and molecular changes in hemiparkinsonian rats. 6-Hydroxydopamine-unilaterally lesioned rats were treated with levodopa (25 mg/kg) + vehicle; levodopa + entacapone (30 mg/kg) or saline, twice daily for 22 days. The LDR and the apomorphine-induced rotations were measured. In situ hybridization was performed measuring the expression of striatal preproenkephalin, preprodynorphin and dopamine D-3 receptor mRNAs, subthalamic cytochrome oxidase mRNA and nigral glutamic acid decarboxylase mRNA. Entacapone potentiated the LDR but did not modify either the apomorphine-induced rotational behavior or the molecular changes. Our results suggest that the effects of entacapone on levodopa-induced motor response are not mediated by postsynaptic mechanisms and that administration of entacapone is not able to normalize the molecular alterations induced by levodopa in the basal ganglia.This work was supported by an unrestricted grant from Novartis-Orion Pharma (Barcelona, Spain). JAO serves as external adviser for Novartis Pharmaceutical (Barcelona, Spain). EA is partially financed by the program: Ayudas para Contratos de Apoyo a la Investigación en el Sistema Nacional de Salud from the Ministerio de Sanidad y Consumo of the Spanish Government.Peer reviewedElsevier201120112008info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/37163reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.nbd.2008.07.019info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/371632026-05-22T06:33:51Z
dc.title.none.fl_str_mv Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
title Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
spellingShingle Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
Marín, Concepció
Parkinson's disease
Levodopa
Entacapone
6-Hydroxydopamine
Preproenkephalin
Preprodynorphin
title_short Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
title_full Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
title_fullStr Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
title_full_unstemmed Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
title_sort Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes
dc.creator.none.fl_str_mv Marín, Concepció
Aguilar, Esther
Mengod Los Arcos, Guadalupe
Cortés, Roser
Rodríguez-Oroz, M. Cruz
Obeso, José Ángel
author Marín, Concepció
author_facet Marín, Concepció
Aguilar, Esther
Mengod Los Arcos, Guadalupe
Cortés, Roser
Rodríguez-Oroz, M. Cruz
Obeso, José Ángel
author_role author
author2 Aguilar, Esther
Mengod Los Arcos, Guadalupe
Cortés, Roser
Rodríguez-Oroz, M. Cruz
Obeso, José Ángel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Parkinson's disease
Levodopa
Entacapone
6-Hydroxydopamine
Preproenkephalin
Preprodynorphin
topic Parkinson's disease
Levodopa
Entacapone
6-Hydroxydopamine
Preproenkephalin
Preprodynorphin
description El pdf del artículo es el manuscrito de autor.
publishDate 2008
dc.date.none.fl_str_mv 2008
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/37163
url http://hdl.handle.net/10261/37163
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.nbd.2008.07.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419601573445632
score 15,81155

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