Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows

Shortly after the discovery of Klotho, interest grew in its potential role in chronic kidney disease (CKD). There are three isoforms of the Klotho protein: alpha Klotho, beta Klotho and gamma Klotho. This review will focus on alpha Klotho due to its relevance as a biomarker in CKD. alpha Klotho is s...

Descripción completa

Detalles Bibliográficos
Autores: Ruiz Torres, María Piedad|||0000-0003-1640-7326, Martin Virgala, Julia, Martín Carro, Beatriz, Fernández Villabrille, Sara, Gómez Alonso, Carlos, Rodríguez García, Minerva, Fernández Martín, José Luis, Alonso Montes, Cristina, Panizo, Sara, Cannata Andía, Jorge B., Naves Díaz, Manuel Luis, Carrillo Lopez, Natalia
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/66073
Acceso en línea:http://hdl.handle.net/10017/66073
https://dx.doi.org/10.3390/ijms25031843.
Access Level:acceso abierto
Palabra clave:Serum sKlotho
Urinary sKlotho
CKD
CKD-MBD
Biomarker
Healthy ageing
Medicina
Medicine
id ES_cb8d899fa321a8cab95158ca650196c8
oai_identifier_str oai:ebuah.uah.es:10017/66073
network_acronym_str ES
network_name_str España
repository_id_str
spelling Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and ShadowsRuiz Torres, María Piedad|||0000-0003-1640-7326Martin Virgala, JuliaMartín Carro, BeatrizFernández Villabrille, SaraGómez Alonso, CarlosRodríguez García, MinervaFernández Martín, José LuisAlonso Montes, CristinaPanizo, SaraCannata Andía, Jorge B.Naves Díaz, Manuel LuisCarrillo Lopez, NataliaSerum sKlothoUrinary sKlothoCKDCKD-MBDBiomarkerHealthy ageingMedicinaMedicineShortly after the discovery of Klotho, interest grew in its potential role in chronic kidney disease (CKD). There are three isoforms of the Klotho protein: alpha Klotho, beta Klotho and gamma Klotho. This review will focus on alpha Klotho due to its relevance as a biomarker in CKD. alpha Klotho is synthesized mainly in the kidneys, but it can be released into the bloodstream and urine as soluble Klotho (sKlotho), which undertakes systemic actions, independently or in combination with FGF23. It is usually accepted that sKlotho levels are reduced early in CKD and that lower levels of sKlotho might be associated with the main chronic kidney disease-mineral bone disorders (CKD-MBDs): cardiovascular and bone disease. However, as results are inconsistent, the applicability of sKlotho as a CKD-MBD biomarker is still a matter of controversy. Much of the inconsistency can be explained due to low sample numbers, the low quality of clinical studies, the lack of standardized assays to assess sKlotho and a lack of consensus on sample processing, especially in urine. In recent decades, because of our longer life expectancies, the prevalence of accelerated-ageing diseases, such as CKD, has increased. Exercise, social interaction and caloric restriction are considered key factors for healthy ageing. While exercise and social interaction seem to be related to higher serum sKlotho levels, it is not clear whether serum sKlotho might be influenced by caloric restriction. This review focuses on the possible role of sKlotho as a biomarker in CKD-MBD, highlighting the difference between solid knowledge and areas requiring further research, including the role of sKlotho in healthy ageing.MDPI20242024-02-03journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/66073https://dx.doi.org/10.3390/ijms25031843.reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/660732026-06-18T11:13:07Z
dc.title.none.fl_str_mv Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
title Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
spellingShingle Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
Ruiz Torres, María Piedad|||0000-0003-1640-7326
Serum sKlotho
Urinary sKlotho
CKD
CKD-MBD
Biomarker
Healthy ageing
Medicina
Medicine
title_short Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
title_full Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
title_fullStr Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
title_full_unstemmed Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
title_sort Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
dc.creator.none.fl_str_mv Ruiz Torres, María Piedad|||0000-0003-1640-7326
Martin Virgala, Julia
Martín Carro, Beatriz
Fernández Villabrille, Sara
Gómez Alonso, Carlos
Rodríguez García, Minerva
Fernández Martín, José Luis
Alonso Montes, Cristina
Panizo, Sara
Cannata Andía, Jorge B.
Naves Díaz, Manuel Luis
Carrillo Lopez, Natalia
author Ruiz Torres, María Piedad|||0000-0003-1640-7326
author_facet Ruiz Torres, María Piedad|||0000-0003-1640-7326
Martin Virgala, Julia
Martín Carro, Beatriz
Fernández Villabrille, Sara
Gómez Alonso, Carlos
Rodríguez García, Minerva
Fernández Martín, José Luis
Alonso Montes, Cristina
Panizo, Sara
Cannata Andía, Jorge B.
Naves Díaz, Manuel Luis
Carrillo Lopez, Natalia
author_role author
author2 Martin Virgala, Julia
Martín Carro, Beatriz
Fernández Villabrille, Sara
Gómez Alonso, Carlos
Rodríguez García, Minerva
Fernández Martín, José Luis
Alonso Montes, Cristina
Panizo, Sara
Cannata Andía, Jorge B.
Naves Díaz, Manuel Luis
Carrillo Lopez, Natalia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Serum sKlotho
Urinary sKlotho
CKD
CKD-MBD
Biomarker
Healthy ageing
Medicina
Medicine
topic Serum sKlotho
Urinary sKlotho
CKD
CKD-MBD
Biomarker
Healthy ageing
Medicina
Medicine
description Shortly after the discovery of Klotho, interest grew in its potential role in chronic kidney disease (CKD). There are three isoforms of the Klotho protein: alpha Klotho, beta Klotho and gamma Klotho. This review will focus on alpha Klotho due to its relevance as a biomarker in CKD. alpha Klotho is synthesized mainly in the kidneys, but it can be released into the bloodstream and urine as soluble Klotho (sKlotho), which undertakes systemic actions, independently or in combination with FGF23. It is usually accepted that sKlotho levels are reduced early in CKD and that lower levels of sKlotho might be associated with the main chronic kidney disease-mineral bone disorders (CKD-MBDs): cardiovascular and bone disease. However, as results are inconsistent, the applicability of sKlotho as a CKD-MBD biomarker is still a matter of controversy. Much of the inconsistency can be explained due to low sample numbers, the low quality of clinical studies, the lack of standardized assays to assess sKlotho and a lack of consensus on sample processing, especially in urine. In recent decades, because of our longer life expectancies, the prevalence of accelerated-ageing diseases, such as CKD, has increased. Exercise, social interaction and caloric restriction are considered key factors for healthy ageing. While exercise and social interaction seem to be related to higher serum sKlotho levels, it is not clear whether serum sKlotho might be influenced by caloric restriction. This review focuses on the possible role of sKlotho as a biomarker in CKD-MBD, highlighting the difference between solid knowledge and areas requiring further research, including the role of sKlotho in healthy ageing.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-02-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/66073
https://dx.doi.org/10.3390/ijms25031843.
url http://hdl.handle.net/10017/66073
https://dx.doi.org/10.3390/ijms25031843.
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419598169767936
score 15,812429

Similares en LA Referencia