Depth sensitivity of frequency domain optical measurements in diffusive media

The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Further...

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Authors: BINZONI, TIZIANO, SASSAROLI, ANGELO, TORRICELLI, ALESSANDRO, SPINELLI, LORENZO, FARINA, ANDREA, DURDURAN, TURGUT, CAVALIER, STEFANO, PIFFERI, ANTONIO, MARTELLI, FABRIZIO
Format: article
Publication Date:2017
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/104599
Online Access:https://hdl.handle.net/2117/104599
Access Level:Open access
Keyword:photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
id ES_cb83e6da22bf2d84f2a1909cd53dc1ea
oai_identifier_str oai:upcommons.upc.edu:2117/104599
network_acronym_str ES
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spelling Depth sensitivity of frequency domain optical measurements in diffusive mediaBINZONI, TIZIANOSASSAROLI, ANGELOTORRICELLI, ALESSANDROSPINELLI, LORENZOFARINA, ANDREADURDURAN, TURGUTCAVALIER, STEFANOPIFFERI, ANTONIOMARTELLI, FABRIZIOphotonsoptical measurementsFotonsÀrees temàtiques de la UPC::FísicaThe depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy.OSA20172017-06-0120172017-05-18journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/10459928663921reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructuresopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1045992026-05-27T15:37:01Z
dc.title.none.fl_str_mv Depth sensitivity of frequency domain optical measurements in diffusive media
title Depth sensitivity of frequency domain optical measurements in diffusive media
spellingShingle Depth sensitivity of frequency domain optical measurements in diffusive media
BINZONI, TIZIANO
photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
title_short Depth sensitivity of frequency domain optical measurements in diffusive media
title_full Depth sensitivity of frequency domain optical measurements in diffusive media
title_fullStr Depth sensitivity of frequency domain optical measurements in diffusive media
title_full_unstemmed Depth sensitivity of frequency domain optical measurements in diffusive media
title_sort Depth sensitivity of frequency domain optical measurements in diffusive media
dc.creator.none.fl_str_mv BINZONI, TIZIANO
SASSAROLI, ANGELO
TORRICELLI, ALESSANDRO
SPINELLI, LORENZO
FARINA, ANDREA
DURDURAN, TURGUT
CAVALIER, STEFANO
PIFFERI, ANTONIO
MARTELLI, FABRIZIO
author BINZONI, TIZIANO
author_facet BINZONI, TIZIANO
SASSAROLI, ANGELO
TORRICELLI, ALESSANDRO
SPINELLI, LORENZO
FARINA, ANDREA
DURDURAN, TURGUT
CAVALIER, STEFANO
PIFFERI, ANTONIO
MARTELLI, FABRIZIO
author_role author
author2 SASSAROLI, ANGELO
TORRICELLI, ALESSANDRO
SPINELLI, LORENZO
FARINA, ANDREA
DURDURAN, TURGUT
CAVALIER, STEFANO
PIFFERI, ANTONIO
MARTELLI, FABRIZIO
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
topic photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
description The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-06-01
2017
2017-05-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/104599
28663921
url https://hdl.handle.net/2117/104599
identifier_str_mv 28663921
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructures
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv OSA
publisher.none.fl_str_mv OSA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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