The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial

A polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. Fifty-one older adults (mean age: 78 years) completed an 8-week randomized-contr...

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Autores: Meroño, Tomás, Peron, Gregorio, Gargari, Giorgio, González-Domínguez, Raúl, Miñarro Alonso, Antonio, Vegas Lozano, Esteban, Hidalgo Liberona, Nicole, Del Bo, Cristian, Bernardi, Stefano, Kroon, Paul A., Carrieri, Barbara, Cherubini, Antonio, Riso, Patrizia, Guglielmetti, Simone, Andrés Lacueva, Ma. Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192552
Acceso en línea:https://hdl.handle.net/2445/192552
Access Level:acceso abierto
Palabra clave:Polifenols
Envelliment
Microbiota
Polyphenols
Aging
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spelling The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trialMeroño, TomásPeron, GregorioGargari, GiorgioGonzález-Domínguez, RaúlMiñarro Alonso, AntonioVegas Lozano, EstebanHidalgo Liberona, NicoleDel Bo, CristianBernardi, StefanoKroon, Paul A.Carrieri, BarbaraCherubini, AntonioRiso, PatriziaGuglielmetti, SimoneAndrés Lacueva, Ma. CristinaPolifenolsEnvellimentMicrobiotaPolyphenolsAgingMicrobiotaA polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. Fifty-one older adults (mean age: 78 years) completed an 8-week randomized-controlled-crossover trial comparing the effects of a polyphenol-rich vs. a control diet on IP, assessed through zonulin levels. Plasma and urinary metabolomics were evaluated with a semi-targeted UHPLC-MS/MS method. Gut microbiota was characterized by 16S rRNA gene profiling. UMs were determined according to urolithin excretion in 24 h urine samples. Multivariate statistics were used to characterize the differences in metabolomic and metataxonomic responses across UMs. Thirty-three participants were classified as urolithin metabotype A (UMA), 13 as urolithin metabotype B (UMB), and 5 as urolithin metabotype 0 (UM0) according to their urinary excretion of urolithins. Clinical, dietary, and biochemical characteristics at baseline were similar between UMs (all p > 0.05). After the polyphenol-rich diet, UMB vs. UMA participants showed a 2-fold higher improvement of zonulin levels (p for interaction = 0.033). Moreover, UMB vs. UMA participants were characterized for alterations in fatty acid metabolism, kynurenine pathway of tryptophan catabolism, and microbial metabolization of phenolic acids. These changes were correlated with the reduction of zonulin levels and modifications of gut microbes (increased Clostridiales, including, R. lactaris, and G. formicilis). In conclusion, urolithin-based metabotyping identified older adults with a higher improvement of IP after a polyphenol-rich diet. Our results reinforce the concept that UMs may contribute to tailor personalized nutrition interventions.Elsevier B.V.2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192552Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.foodres.2022.111632Food Research International, 2022, vol. 159https://doi.org/10.1016/j.foodres.2022.111632cc-by (c) Tomás Meroño, et al. 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1925522026-05-29T05:05:01Z
dc.title.none.fl_str_mv The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
title The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
spellingShingle The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
Meroño, Tomás
Polifenols
Envelliment
Microbiota
Polyphenols
Aging
Microbiota
title_short The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
title_full The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
title_fullStr The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
title_full_unstemmed The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
title_sort The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial
dc.creator.none.fl_str_mv Meroño, Tomás
Peron, Gregorio
Gargari, Giorgio
González-Domínguez, Raúl
Miñarro Alonso, Antonio
Vegas Lozano, Esteban
Hidalgo Liberona, Nicole
Del Bo, Cristian
Bernardi, Stefano
Kroon, Paul A.
Carrieri, Barbara
Cherubini, Antonio
Riso, Patrizia
Guglielmetti, Simone
Andrés Lacueva, Ma. Cristina
author Meroño, Tomás
author_facet Meroño, Tomás
Peron, Gregorio
Gargari, Giorgio
González-Domínguez, Raúl
Miñarro Alonso, Antonio
Vegas Lozano, Esteban
Hidalgo Liberona, Nicole
Del Bo, Cristian
Bernardi, Stefano
Kroon, Paul A.
Carrieri, Barbara
Cherubini, Antonio
Riso, Patrizia
Guglielmetti, Simone
Andrés Lacueva, Ma. Cristina
author_role author
author2 Peron, Gregorio
Gargari, Giorgio
González-Domínguez, Raúl
Miñarro Alonso, Antonio
Vegas Lozano, Esteban
Hidalgo Liberona, Nicole
Del Bo, Cristian
Bernardi, Stefano
Kroon, Paul A.
Carrieri, Barbara
Cherubini, Antonio
Riso, Patrizia
Guglielmetti, Simone
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Polifenols
Envelliment
Microbiota
Polyphenols
Aging
Microbiota
topic Polifenols
Envelliment
Microbiota
Polyphenols
Aging
Microbiota
description A polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. Fifty-one older adults (mean age: 78 years) completed an 8-week randomized-controlled-crossover trial comparing the effects of a polyphenol-rich vs. a control diet on IP, assessed through zonulin levels. Plasma and urinary metabolomics were evaluated with a semi-targeted UHPLC-MS/MS method. Gut microbiota was characterized by 16S rRNA gene profiling. UMs were determined according to urolithin excretion in 24 h urine samples. Multivariate statistics were used to characterize the differences in metabolomic and metataxonomic responses across UMs. Thirty-three participants were classified as urolithin metabotype A (UMA), 13 as urolithin metabotype B (UMB), and 5 as urolithin metabotype 0 (UM0) according to their urinary excretion of urolithins. Clinical, dietary, and biochemical characteristics at baseline were similar between UMs (all p > 0.05). After the polyphenol-rich diet, UMB vs. UMA participants showed a 2-fold higher improvement of zonulin levels (p for interaction = 0.033). Moreover, UMB vs. UMA participants were characterized for alterations in fatty acid metabolism, kynurenine pathway of tryptophan catabolism, and microbial metabolization of phenolic acids. These changes were correlated with the reduction of zonulin levels and modifications of gut microbes (increased Clostridiales, including, R. lactaris, and G. formicilis). In conclusion, urolithin-based metabotyping identified older adults with a higher improvement of IP after a polyphenol-rich diet. Our results reinforce the concept that UMs may contribute to tailor personalized nutrition interventions.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192552
url https://hdl.handle.net/2445/192552
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.foodres.2022.111632
Food Research International, 2022, vol. 159
https://doi.org/10.1016/j.foodres.2022.111632
dc.rights.none.fl_str_mv cc-by (c) Tomás Meroño, et al. 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Tomás Meroño, et al. 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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