Enamel proteome shows that Gigantopithecus was an early diverging pongine
Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago),...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/56606 |
| Acceso en línea: | http://hdl.handle.net/10230/56606 http://dx.doi.org/10.1038/s41586-019-1728-8 |
| Access Level: | acceso abierto |
| Palabra clave: | Biological anthropology Palaeontology Phylogenetics Proteomics |
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Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| title |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| spellingShingle |
Enamel proteome shows that Gigantopithecus was an early diverging pongine Welker, Frido Biological anthropology Palaeontology Phylogenetics Proteomics |
| title_short |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| title_full |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| title_fullStr |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| title_full_unstemmed |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| title_sort |
Enamel proteome shows that Gigantopithecus was an early diverging pongine |
| dc.creator.none.fl_str_mv |
Welker, Frido Ramos-Madrigal, Jazmín Kuhlwilm, Martin Liao, Wei Gutenbrunner, Petra de Manuel, Marc Samodova, Diana Mackie, Meaghan Allentoft, Morten E. Bacon, Anne-Marie Collins, Matthew J. Cox, Jürgen Lalueza Fox, Carles, 1965- Olsen, Jesper V. Demeter, Fabrice Wang, Wei Marquès i Bonet, Tomàs, 1975- Cappellini, Enrico |
| author |
Welker, Frido |
| author_facet |
Welker, Frido Ramos-Madrigal, Jazmín Kuhlwilm, Martin Liao, Wei Gutenbrunner, Petra de Manuel, Marc Samodova, Diana Mackie, Meaghan Allentoft, Morten E. Bacon, Anne-Marie Collins, Matthew J. Cox, Jürgen Lalueza Fox, Carles, 1965- Olsen, Jesper V. Demeter, Fabrice Wang, Wei Marquès i Bonet, Tomàs, 1975- Cappellini, Enrico |
| author_role |
author |
| author2 |
Ramos-Madrigal, Jazmín Kuhlwilm, Martin Liao, Wei Gutenbrunner, Petra de Manuel, Marc Samodova, Diana Mackie, Meaghan Allentoft, Morten E. Bacon, Anne-Marie Collins, Matthew J. Cox, Jürgen Lalueza Fox, Carles, 1965- Olsen, Jesper V. Demeter, Fabrice Wang, Wei Marquès i Bonet, Tomàs, 1975- Cappellini, Enrico |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Biological anthropology Palaeontology Phylogenetics Proteomics |
| topic |
Biological anthropology Palaeontology Phylogenetics Proteomics |
| description |
Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3. Hypotheses regarding the relationships between Gigantopithecus and extinct and extant hominids are wide ranging but difficult to substantiate because of its highly derived dentognathic morphology, the absence of cranial and post-cranial remains1,3-6, and the lack of independent molecular validation. We retrieved dental enamel proteome sequences from a 1.9-million-year-old G. blacki molar found in Chuifeng Cave, China7,8. The thermal age of these protein sequences is approximately five times greater than that of any previously published mammalian proteome or genome. We demonstrate that Gigantopithecus is a sister clade to orangutans (genus Pongo) with a common ancestor about 12-10 million years ago, implying that the divergence of Gigantopithecus from Pongo forms part of the Miocene radiation of great apes. In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns that characterize the large molars in Gigantopithecus9,10. The survival of an Early Pleistocene dental enamel proteome in the subtropics further expands the scope of palaeoproteomic analysis into geographical areas and time periods previously considered incompatible with the preservation of substantial amounts of genetic information. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2023 2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/56606 http://dx.doi.org/10.1038/s41586-019-1728-8 |
| url |
http://hdl.handle.net/10230/56606 http://dx.doi.org/10.1038/s41586-019-1728-8 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Nature. 2019;576(7786):262-5 info:eu-repo/grantAgreement/EC/H2020/795569 info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P info:eu-repo/grantAgreement/EC/H2020/722606 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Research |
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Nature Research |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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1869419571290570752 |
| spelling |
Enamel proteome shows that Gigantopithecus was an early diverging pongineWelker, FridoRamos-Madrigal, JazmínKuhlwilm, MartinLiao, WeiGutenbrunner, Petrade Manuel, MarcSamodova, DianaMackie, MeaghanAllentoft, Morten E.Bacon, Anne-MarieCollins, Matthew J.Cox, JürgenLalueza Fox, Carles, 1965-Olsen, Jesper V.Demeter, FabriceWang, WeiMarquès i Bonet, Tomàs, 1975-Cappellini, EnricoBiological anthropologyPalaeontologyPhylogeneticsProteomicsGigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3. Hypotheses regarding the relationships between Gigantopithecus and extinct and extant hominids are wide ranging but difficult to substantiate because of its highly derived dentognathic morphology, the absence of cranial and post-cranial remains1,3-6, and the lack of independent molecular validation. We retrieved dental enamel proteome sequences from a 1.9-million-year-old G. blacki molar found in Chuifeng Cave, China7,8. The thermal age of these protein sequences is approximately five times greater than that of any previously published mammalian proteome or genome. We demonstrate that Gigantopithecus is a sister clade to orangutans (genus Pongo) with a common ancestor about 12-10 million years ago, implying that the divergence of Gigantopithecus from Pongo forms part of the Miocene radiation of great apes. In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns that characterize the large molars in Gigantopithecus9,10. The survival of an Early Pleistocene dental enamel proteome in the subtropics further expands the scope of palaeoproteomic analysis into geographical areas and time periods previously considered incompatible with the preservation of substantial amounts of genetic information.E.C. and F.W. are supported by VILLUM FONDEN (17649) and by the European Commission through a Marie Skłodowska-Curie (MSCA) Individual Fellowship (795569). T.M.-B. is supported by BFU2017-86471-P (MINECO/FEDER, UE), NIHM grant U01 MH106874, Howard Hughes International Early Career grant, Obra Social ‘La Caixa’ and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). E.C., J.C., J.V.O., D.S. and P.G. are supported by the Marie Skłodowska-Curie European Training Network (ETN) TEMPERA, a project funded by the European Union’s EU Framework Program for Research and Innovation Horizon 2020 under grant agreement no. 722606. M.J.C. and M.M. are supported by the Danish National Research Foundation award PROTEIOS (DNRF128). Work at the Novo Nordisk Foundation Center for Protein Research is funded in part by a donation from the Novo Nordisk Foundation (NNF14CC0001). Research at Chuifeng Cave is made possible by support from the National Natural Science Foundation of China (41572023) and by a grant from the Bagui Scholar of Guangxi. M.K. was supported by a Deutsche Forschungsgemeinschaft (DFG) fellowship (KU 3467/1-1) and the Postdoctoral Junior Leader Fellowship Programme from ‘la Caixa’ Banking Foundation (LCF/BQ/PR19/11700002). M.E.A. is supported by the Independent Research Fund Denmark (7027-00147B). We thank E. Willerslev for critical reading of the manuscript, scientific support and guidance.Nature Research202320232019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56606http://dx.doi.org/10.1038/s41586-019-1728-8reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNature. 2019;576(7786):262-5info:eu-repo/grantAgreement/EC/H2020/795569info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-Pinfo:eu-repo/grantAgreement/EC/H2020/722606© Springer Nature Publishing AG Welker F, Ramos-Madrigal J, Kuhlwilm M, Liao W, Gutenbrunner P, de Manuel M, Samodova D, Mackie M, Allentoft ME, Bacon AM, Collins MJ, Cox J, Lalueza-Fox C, Olsen JV, Demeter F, Wang W, Marques-Bonet T, Cappellini E. Enamel proteome shows that Gigantopithecus was an early diverging pongine. Nature. 2019;576(7786):262-5 [http://dx.doi.org/10.1038/s41586-019-1728-8]info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/566062026-06-12T07:21:37Z |
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