Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble bi...

Descripción completa

Detalles Bibliográficos
Autores: Ruiz-de-Leon, Maria J., Jimenez-Sousa, Maria A., Moreno, Santiago, Garcia, Marcial, Gutierrez-Rivas, Monica, León García, Agathe, Montero-Alonso, Marta, Gonzalez-Garcia, Juan, Resino, Salvador, Rallón, Norma, Benito, José M., Vallejo, Alejandro, ECRIS Network integrated in the Spanish AIDS Resea
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/163507
Acceso en línea:https://hdl.handle.net/2445/163507
Access Level:acceso abierto
Palabra clave:Cèl·lules T
VIH (Virus)
Micro RNAs
Marcadors bioquímics
T cells
HIV (Viruses)
MicroRNAs
Biochemical markers
Descripción
Sumario:Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

Similares en LA Referencia