Neuroprotective properties of queen bee acid by autophagy induction.

Martínez-Chacón G; Paredes-Barquero M; Yakhine-Diop SMS; Uribe-Carretero E; Bargiela A; Sabater-Arcis M; Morales-García J; Alarcón-Gil J; Alegre-Cortés E; Canales-Cortés S; Rodríguez-Arribas M; Camello PJ; Pedro JMB; Perez-Castillo A; Artero R; Gonzalez-Polo RA; Fuentes JM; Niso-Santano M

Neuroprotective properties of queen bee acid by autophagy induction.

Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there i...

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Autores:	Martínez-Chacón G, Paredes-Barquero M, Yakhine-Diop SMS, Uribe-Carretero E, Bargiela A, Sabater-Arcis M, Morales-García J, Alarcón-Gil J, Alegre-Cortés E, Canales-Cortés S, Rodríguez-Arribas M, Camello PJ, Pedro JMB, Perez-Castillo A, Artero R, Gonzalez-Polo RA, Fuentes JM, Niso-Santano M
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Centro de Investigación Principe Felipe (CIPF)
Repositorio:	r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
OAI Identifier:	oai:cipf.fundanetsuite.com:p3822
Acceso en línea:	https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3822
Access Level:	acceso abierto
Palabra clave:	Autophagy, Longevity, Neurodegeneration, Parkinson’s disease, QBA, SIRT1

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spelling	Neuroprotective properties of queen bee acid by autophagy induction.Martínez-Chacón GParedes-Barquero MYakhine-Diop SMSUribe-Carretero EBargiela ASabater-Arcis MMorales-García JAlarcón-Gil JAlegre-Cortés ECanales-Cortés SRodríguez-Arribas MCamello PJPedro JMBPerez-Castillo AArtero RGonzalez-Polo RAFuentes JMNiso-Santano MAutophagy, Longevity, Neurodegeneration, Parkinson’s disease, QBA, SIRT1Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson's disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA.SPRINGER2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3822CELL BIOLOGY AND TOXICOLOGYISSN: 07422091ISSNe: 15736822reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)instname:Centro de Investigación Principe Felipe (CIPF)Inglésinfo:eu-repo/semantics/openAccessoai:cipf.fundanetsuite.com:p38222026-06-17T11:19:47Z
dc.title.none.fl_str_mv	Neuroprotective properties of queen bee acid by autophagy induction.
title	Neuroprotective properties of queen bee acid by autophagy induction.
spellingShingle	Neuroprotective properties of queen bee acid by autophagy induction. Martínez-Chacón G Autophagy, Longevity, Neurodegeneration, Parkinson’s disease, QBA, SIRT1
title_short	Neuroprotective properties of queen bee acid by autophagy induction.
title_full	Neuroprotective properties of queen bee acid by autophagy induction.
title_fullStr	Neuroprotective properties of queen bee acid by autophagy induction.
title_full_unstemmed	Neuroprotective properties of queen bee acid by autophagy induction.
title_sort	Neuroprotective properties of queen bee acid by autophagy induction.
dc.creator.none.fl_str_mv	Martínez-Chacón G Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M
author	Martínez-Chacón G
author_facet	Martínez-Chacón G Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M
author_role	author
author2	Paredes-Barquero M Yakhine-Diop SMS Uribe-Carretero E Bargiela A Sabater-Arcis M Morales-García J Alarcón-Gil J Alegre-Cortés E Canales-Cortés S Rodríguez-Arribas M Camello PJ Pedro JMB Perez-Castillo A Artero R Gonzalez-Polo RA Fuentes JM Niso-Santano M
author2_role	author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Autophagy, Longevity, Neurodegeneration, Parkinson’s disease, QBA, SIRT1
topic	Autophagy, Longevity, Neurodegeneration, Parkinson’s disease, QBA, SIRT1
description	Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson's disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3822
url	https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3822
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	SPRINGER
publisher.none.fl_str_mv	SPRINGER
dc.source.none.fl_str_mv	CELL BIOLOGY AND TOXICOLOGY ISSN: 07422091 ISSNe: 15736822 reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname:Centro de Investigación Principe Felipe (CIPF)
instname_str	Centro de Investigación Principe Felipe (CIPF)
reponame_str	r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
collection	r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Neuroprotective properties of queen bee acid by autophagy induction.

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