Cooperative interactions of stem and niche cells during skeletal muscle regeneration: role of IL-6 signaling
Adult skeletal muscle has a remarkable capacity of self-repairing after damage. The cellular communication processes and mediator molecules in the regenerative microenvironment that control muscle stem cell functions are poorly characterized. Muscle resident fibro/adipogenic progenitors (FAPs) are r...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/482050 |
| Acceso en línea: | http://hdl.handle.net/10803/482050 |
| Access Level: | acceso abierto |
| Palabra clave: | Skeletal muscle regeneration Muscle stem cells Mesenchymal fibro/adipogenic progenitors Neutrophils Interleukin-6 Regeneració del múscul esquelètic Cèl·lules mare musculars Progenitors mesenquimals fibro/adipogènics Neutròfils Interleucina-6 576 |
| Sumario: | Adult skeletal muscle has a remarkable capacity of self-repairing after damage. The cellular communication processes and mediator molecules in the regenerative microenvironment that control muscle stem cell functions are poorly characterized. Muscle resident fibro/adipogenic progenitors (FAPs) are responsible of the fibrotic and adipose degeneration of muscle in pathological situations. In contrast with this function, here we demonstrate that blood-infiltrating neutrophils cooperate with FAPs to promote muscle regeneration after injury. By cell-type specific gene deletion and transplantation experiments, here we show the requirement of the soluble form of interleukin 6 (IL-6) receptor released by neutrophils and FAP-derived IL-6 to activate IL-6 trans-signaling for efficient muscle stem cell proliferative and regenerative functions. Exploitation of this physiological mechanism may be of therapeutic importance in pathologies coursing with poor regeneration of skeletal muscle. |
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