Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view
Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people worldwide. Secondgeneration antipsychotics (SGAs) are the cornerstone in the management of schizophrenia. However, despite their efficacy in counteracting both positive and negative symptomatology of schizophreni...
| Autores: | , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2019 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositório: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.uam.es:10486/692576 |
| Acesso em linha: | http://hdl.handle.net/10486/692576 https://dx.doi.org/10.1016/j.bbalip.2019.158534 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Adipose tissue Antipsychotics Schizophrenia Lipid metabolism Adipocyte differentiation Thermogenesis Browning Medicina |
| Resumo: | Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people worldwide. Secondgeneration antipsychotics (SGAs) are the cornerstone in the management of schizophrenia. However, despite their efficacy in counteracting both positive and negative symptomatology of schizophrenia, recent clinical observations have described an increase in the prevalence of metabolic disturbances in patients treated with SGAs, including abnormal weight gain, hyperglycemia and dyslipidemia. While the molecular mechanisms responsible for these side-effects remain poorly understood, increasing evidence points to a link between SGAs and adipose tissue depots of white, brown and beige adipocytes. In this review, we survey the present knowledge in this area, with a particular focus on the molecular aspects of adipocyte biology including differentiation, lipid metabolism, thermogenic function and the browning/beiging process |
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