Targeting HIV persistence in the tissue

HIV; Tissue

Detalles Bibliográficos
Autores: Pieren, Daan, Benítez Martínez, Aleix, Genescà Ferrer, Meritxell
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/11034
Acceso en línea:https://hdl.handle.net/11351/11034
Access Level:acceso abierto
Palabra clave:Infeccions per VIH
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
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spelling Targeting HIV persistence in the tissuePieren, DaanBenítez Martínez, AleixGenescà Ferrer, MeritxellInfeccions per VIHDISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV InfectionsPHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus LatencyENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIHFENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viralHIV; TissueVIH; TejidoVIH; TeixitPurpose of review The complex nature and distribution of the HIV reservoir in tissue of people with HIV remains one of the major obstacles to achieve the elimination of HIV persistence. Challenges include the tissue-specific states of latency and viral persistence, which translates into high levels of reservoir heterogeneity. Moreover, the best strategies to reach and eliminate these reservoirs may differ based on the intrinsic characteristics of the cellular and anatomical reservoir to reach. Recent findings While major focus has been undertaken for lymphoid tissues and follicular T helper cells, evidence of viral persistence in HIV and non-HIV antigen-specific CD4+ T cells and macrophages resident in multiple tissues providing long-term protection presents new challenges in the quest for an HIV cure. Considering the microenvironments where these cellular reservoirs persist opens new venues for the delivery of drugs and immunotherapies to target these niches. New tools, such as single-cell RNA sequencing, CRISPR screenings, mRNA technology or tissue organoids are quickly developing and providing detailed information about the complex nature of the tissue reservoirs. Summary Targeting persistence in tissue reservoirs represents a complex but essential step towards achieving HIV cure. Combinatorial strategies, particularly during the early phases of infection to impact initial reservoirs, capable of reaching and reactivating multiple long-lived reservoirs in the body may lead the path.This work was primarily supported by grants from the Spanish Health Institute Carlos III (PI20/00160), co-funded by ERDF/ESF, “A way to make Europe”/“Investing in your future”, the Fundació La Marató TV3 (202112–30 FMTV3) and the Gilead fellowships GLD21/00049.Wolters Kluwer HealthInstitut Català de la SalutServei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/11034Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésCurrent Opinion in HIV and AIDS;19(2)https://doi.org/10.1097/COH.0000000000000836info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00160Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/110342026-06-12T09:38:37Z
dc.title.none.fl_str_mv Targeting HIV persistence in the tissue
title Targeting HIV persistence in the tissue
spellingShingle Targeting HIV persistence in the tissue
Pieren, Daan
Infeccions per VIH
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
title_short Targeting HIV persistence in the tissue
title_full Targeting HIV persistence in the tissue
title_fullStr Targeting HIV persistence in the tissue
title_full_unstemmed Targeting HIV persistence in the tissue
title_sort Targeting HIV persistence in the tissue
dc.creator.none.fl_str_mv Pieren, Daan
Benítez Martínez, Aleix
Genescà Ferrer, Meritxell
author Pieren, Daan
author_facet Pieren, Daan
Benítez Martínez, Aleix
Genescà Ferrer, Meritxell
author_role author
author2 Benítez Martínez, Aleix
Genescà Ferrer, Meritxell
author2_role author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Infeccions per VIH
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
topic Infeccions per VIH
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
description HIV; Tissue
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/11034
url https://hdl.handle.net/11351/11034
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Current Opinion in HIV and AIDS;19(2)
https://doi.org/10.1097/COH.0000000000000836
info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00160
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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