Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease

Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (SNCA) transcri...

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Autores: Marsal-García, Laura|||0000-0002-6337-1656, Campdelacreu, Jaume|||0000-0001-9196-7601, Vilas Rolán, Dolores|||0000-0003-3084-053X, Ispierto, Lourdes, Gascon Bayarri, Jordi|||0000-0002-9422-937X, Reñé, Ramón, Álvarez, Ramiro|||0000-0002-8053-7232, Beyer, Katrin|||0000-0001-8905-1514, Urbizu, Aintzane|||0000-0001-8458-1209, Arnaldo, Laura|||0000-0003-1654-0573
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236291
Acceso en línea:https://ddd.uab.cat/record/236291
https://dx.doi.org/urn:doi:10.3390/ijms22020725
Access Level:acceso abierto
Palabra clave:Alpha-synuclein
SNCA transcript variants
Dementia with Lewy bodies
Parkinson's disease
Differential mRNA transcript expression
Peripheral biomarker
Disease progression
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spelling Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's DiseaseMarsal-García, Laura|||0000-0002-6337-1656Campdelacreu, Jaume|||0000-0001-9196-7601Vilas Rolán, Dolores|||0000-0003-3084-053XIspierto, LourdesGascon Bayarri, Jordi|||0000-0002-9422-937XReñé, RamónÁlvarez, Ramiro|||0000-0002-8053-7232Beyer, Katrin|||0000-0001-8905-1514Urbizu, Aintzane|||0000-0001-8458-1209Arnaldo, Laura|||0000-0003-1654-0573Alpha-synucleinSNCA transcript variantsDementia with Lewy bodiesParkinson's diseaseDifferential mRNA transcript expressionPeripheral biomarkerDisease progressionLewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (SNCA) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, and SNCA112, in 45 LBD and control temporal cortex samples and in the blood of 72 DLB, 59 PD, and 54 control subjects. The results revealed overexpression of SNCAtv1 and SNCA112 in DLB, and SNCAtv2 in PD temporal cortices. In DLB blood, diminution of all SNCA transcripts was observed. SNCAtv1 and SNCAtv2 were diminished in PD with disease onset before 70 years. SNCAtv3, driven by its own promoter, showed opposite expression in early DLB and PD, suggesting that its amount may be an early, DLB specific biomarker. Correlation between blood transcript levels and disease duration was positive in DLB and negative in PD, possibly reflecting differences in brain alpha-synuclein aggregation rates associated with differences in disease courses. In conclusion, SNCA transcripts showed a disease-specific increase in the brain and were diminished in blood of LBD patients. SNCAtv3 expression was decreased in early DLB and increased in early PD and could be a biomarker for early DLB diagnosis.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236291https://dx.doi.org/urn:doi:10.3390/ijms22020725reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI15-00216Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-00276open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2362912026-06-06T12:50:31Z
dc.title.none.fl_str_mv Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
title Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
spellingShingle Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
Marsal-García, Laura|||0000-0002-6337-1656
Alpha-synuclein
SNCA transcript variants
Dementia with Lewy bodies
Parkinson's disease
Differential mRNA transcript expression
Peripheral biomarker
Disease progression
title_short Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
title_full Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
title_fullStr Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
title_full_unstemmed Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
title_sort Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease
dc.creator.none.fl_str_mv Marsal-García, Laura|||0000-0002-6337-1656
Campdelacreu, Jaume|||0000-0001-9196-7601
Vilas Rolán, Dolores|||0000-0003-3084-053X
Ispierto, Lourdes
Gascon Bayarri, Jordi|||0000-0002-9422-937X
Reñé, Ramón
Álvarez, Ramiro|||0000-0002-8053-7232
Beyer, Katrin|||0000-0001-8905-1514
Urbizu, Aintzane|||0000-0001-8458-1209
Arnaldo, Laura|||0000-0003-1654-0573
author Marsal-García, Laura|||0000-0002-6337-1656
author_facet Marsal-García, Laura|||0000-0002-6337-1656
Campdelacreu, Jaume|||0000-0001-9196-7601
Vilas Rolán, Dolores|||0000-0003-3084-053X
Ispierto, Lourdes
Gascon Bayarri, Jordi|||0000-0002-9422-937X
Reñé, Ramón
Álvarez, Ramiro|||0000-0002-8053-7232
Beyer, Katrin|||0000-0001-8905-1514
Urbizu, Aintzane|||0000-0001-8458-1209
Arnaldo, Laura|||0000-0003-1654-0573
author_role author
author2 Campdelacreu, Jaume|||0000-0001-9196-7601
Vilas Rolán, Dolores|||0000-0003-3084-053X
Ispierto, Lourdes
Gascon Bayarri, Jordi|||0000-0002-9422-937X
Reñé, Ramón
Álvarez, Ramiro|||0000-0002-8053-7232
Beyer, Katrin|||0000-0001-8905-1514
Urbizu, Aintzane|||0000-0001-8458-1209
Arnaldo, Laura|||0000-0003-1654-0573
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Alpha-synuclein
SNCA transcript variants
Dementia with Lewy bodies
Parkinson's disease
Differential mRNA transcript expression
Peripheral biomarker
Disease progression
topic Alpha-synuclein
SNCA transcript variants
Dementia with Lewy bodies
Parkinson's disease
Differential mRNA transcript expression
Peripheral biomarker
Disease progression
description Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (SNCA) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, and SNCA112, in 45 LBD and control temporal cortex samples and in the blood of 72 DLB, 59 PD, and 54 control subjects. The results revealed overexpression of SNCAtv1 and SNCA112 in DLB, and SNCAtv2 in PD temporal cortices. In DLB blood, diminution of all SNCA transcripts was observed. SNCAtv1 and SNCAtv2 were diminished in PD with disease onset before 70 years. SNCAtv3, driven by its own promoter, showed opposite expression in early DLB and PD, suggesting that its amount may be an early, DLB specific biomarker. Correlation between blood transcript levels and disease duration was positive in DLB and negative in PD, possibly reflecting differences in brain alpha-synuclein aggregation rates associated with differences in disease courses. In conclusion, SNCA transcripts showed a disease-specific increase in the brain and were diminished in blood of LBD patients. SNCAtv3 expression was decreased in early DLB and increased in early PD and could be a biomarker for early DLB diagnosis.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/236291
https://dx.doi.org/urn:doi:10.3390/ijms22020725
url https://ddd.uab.cat/record/236291
https://dx.doi.org/urn:doi:10.3390/ijms22020725
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI15-00216
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-00276
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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