Insights into the causal role of diesel exhaust particles in ventricular arrhythmogenesis: protective effects of antioxidant cerium oxide nanoparticles

[Background] Epidemiological studies suggest an association between air pollution and ventricular arrhythmias, with reactive oxygen species (ROS) playing a crucial role. However, the causal relationship and long-term effects remain uncertain, and the effectiveness of interventions aimed at reducing...

Descripción completa

Detalles Bibliográficos
Autores: Ganse, Freddy G., Ernst, Lena M., Rodríguez-Sinovas, Cristina, Ruíz-Meana, Marisol, Inserte, Javier, Martínez-González, José, Briones, Ana M., García-Redondo, Ana Belén, Consegal, Marta, Miró-Casas, Elisabet, Yáñez-Bisbe, Laia, Pomposo, Aitor, Prades-Martínez, Marta, Ferreira-González, Ignacio, Puntes, Víctor F., Benito, Begoña, Rodríguez-Sinovas, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/413156
Acceso en línea:http://hdl.handle.net/10261/413156
https://api.elsevier.com/content/abstract/scopus_id/105025826770
Access Level:acceso abierto
Palabra clave:Air pollution
Cerium oxide
Fibrosis
Oxidative stress
Ventricular arrhythmias
Descripción
Sumario:[Background] Epidemiological studies suggest an association between air pollution and ventricular arrhythmias, with reactive oxygen species (ROS) playing a crucial role. However, the causal relationship and long-term effects remain uncertain, and the effectiveness of interventions aimed at reducing ROS requires further investigation. Here we aimed to evaluate the effects of a 3-weeks exposure to diesel exhaust particles (DEPs) on ventricular arrhythmogenesis, explore the underlying mechanisms, and assess the potential of cerium oxide nanoparticles (CeO2NP) as a ROS-detoxifying intervention.

Similares en LA Referencia