Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks

Integrating new information into existing schematic structures of knowledge is the basis of learning in our everyday life activity as it enables structured representation of information and goal-directed behaviour in an ever-changing environment. However, how schematic mnemonic structures aid the in...

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Autores: Nicolás, Berta, Sala Padró, Jacint, Cucurell, David, Santurino, Mila, Falip, Mercè, Fuentemilla Garriga, Lluís
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/174409
Acesso em linha:https://hdl.handle.net/2445/174409
Access Level:Acceso aberto
Palavra-chave:Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
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spelling Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networksNicolás, BertaSala Padró, JacintCucurell, DavidSanturino, MilaFalip, MercèFuentemilla Garriga, LluísHipocamp (Cervell)MemòriaHippocampus (Brain)MemoryIntegrating new information into existing schematic structures of knowledge is the basis of learning in our everyday life activity as it enables structured representation of information and goal-directed behaviour in an ever-changing environment. However, how schematic mnemonic structures aid the integration of novel elements remains poorly understood. Here, we showed that the ability to integrate novel picture information into learn structures of picture associations that overlap by the same picture scene (associative network) or by the conceptually related scene information (schematic network) is hippocampus-dependent, as patients with lesions at the medial temporal lobe (including the hippocampus) were impaired in inferring novel relations between elements within these mnemonic networks but not in retrieving individual pictures in a subsequent memory test. In addition, we observed more persistent and widespread scalp electroencephalographic (EEG) theta oscillatory pattern (3-6Hz) while healthy participants encoded novel pictures related to schematic memory networks, suggesting that theta may reflect distances between elements within a representational network space. Finally, we found high similarity values for neural activity patterns elicited by novel and related events only within associative networks, thereby suggesting that neural reactivation may promote the integration of new information into existing memory networks only when direct associations within the network link their elements. These findings have important implications for our understanding of the neural mechanisms that support the development and organization of structures of knowledge.Elsevier B.V.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174409Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2020.117558Neuroimage, 2021, vol. 226, num. 117558https://doi.org/10.1016/j.neuroimage.2020.117558cc-by-nc-nd (c) Nicolás, Berta et al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1744092026-05-27T06:46:51Z
dc.title.none.fl_str_mv Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
title Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
spellingShingle Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
Nicolás, Berta
Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
title_short Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
title_full Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
title_fullStr Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
title_full_unstemmed Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
title_sort Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks
dc.creator.none.fl_str_mv Nicolás, Berta
Sala Padró, Jacint
Cucurell, David
Santurino, Mila
Falip, Mercè
Fuentemilla Garriga, Lluís
author Nicolás, Berta
author_facet Nicolás, Berta
Sala Padró, Jacint
Cucurell, David
Santurino, Mila
Falip, Mercè
Fuentemilla Garriga, Lluís
author_role author
author2 Sala Padró, Jacint
Cucurell, David
Santurino, Mila
Falip, Mercè
Fuentemilla Garriga, Lluís
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
topic Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
description Integrating new information into existing schematic structures of knowledge is the basis of learning in our everyday life activity as it enables structured representation of information and goal-directed behaviour in an ever-changing environment. However, how schematic mnemonic structures aid the integration of novel elements remains poorly understood. Here, we showed that the ability to integrate novel picture information into learn structures of picture associations that overlap by the same picture scene (associative network) or by the conceptually related scene information (schematic network) is hippocampus-dependent, as patients with lesions at the medial temporal lobe (including the hippocampus) were impaired in inferring novel relations between elements within these mnemonic networks but not in retrieving individual pictures in a subsequent memory test. In addition, we observed more persistent and widespread scalp electroencephalographic (EEG) theta oscillatory pattern (3-6Hz) while healthy participants encoded novel pictures related to schematic memory networks, suggesting that theta may reflect distances between elements within a representational network space. Finally, we found high similarity values for neural activity patterns elicited by novel and related events only within associative networks, thereby suggesting that neural reactivation may promote the integration of new information into existing memory networks only when direct associations within the network link their elements. These findings have important implications for our understanding of the neural mechanisms that support the development and organization of structures of knowledge.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174409
url https://hdl.handle.net/2445/174409
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neuroimage.2020.117558
Neuroimage, 2021, vol. 226, num. 117558
https://doi.org/10.1016/j.neuroimage.2020.117558
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Nicolás, Berta et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Nicolás, Berta et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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